Galactosylation of collagen propeptide hydroxylysines by PLOD3

Stable Identifier
R-HSA-1981128
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The ER membrane-associated enzyme PLOD3 has collagen galactosyltransferase activity (Heikkinen et al. 2000, Wang et al. 2002) though the biological significance of this has been questioned (Schegg et al. 2009).
Literature References
PubMed ID Title Journal Year
12475640 The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro

Myllylä, R, Luosujärvi, H, Uitto, L, Wang, C, Risteli, M, Heikkinen, J

Matrix Biol 2002
10934207 Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity

Myllylä, R, Wang, C, Risteli, M, Rossi, M, Heikkinen, J, Valtavaara, M, Latvala, J

J Biol Chem 2000
Participants
Participates
Catalyst Activity

procollagen galactosyltransferase activity of PLOD3:Fe2+ dimer [endoplasmic reticulum membrane]

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