Reactome | ICOS-1 [plasma membrane]

ICOS-1 [plasma membrane]

Stable Identifier

R-HSA-198144

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Inducible T-cell co-stimulator, ICOS_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y6W8-1 ICOS

Gene Names

ICOS, AILIM

Other Identifiers

11731360_a_at

16889829

210439_PM_at

210439_at

2523879

2523880

2523881

2523885

2523886

2523887

2523889

29851

34607_at

8047702

GE79870

GO:0002376

GO:0002517

GO:0005515

GO:0005576

GO:0005886

GO:0006955

GO:0007155

GO:0016020

GO:0031295

GO:0048856

GO:0098609

HMNXSV003006044

ILMN_1669927

PH_hs_0003666

TC02001202.hg

g5360718_3p_at

Participates

as an input of

ICOS binds ICOSL/B7-H2 (Homo sapiens)

as a component of

ICOS:ICOSL [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y180-ICOS [plasma membrane]

Inferred To

icos [plasma membrane] (Xenopus tropicalis)

Icos [plasma membrane] (Mus musculus)

Icos [plasma membrane] (Rattus norvegicus)

ICOS [plasma membrane] (Bos taurus)

ICOS [plasma membrane] (Canis familiaris)

ICOS-1 [plasma membrane] (Gallus gallus)

ICOS-1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_036224.1

Guide to Pharmacology - Targets

2939

OpenTargets

ENSG00000163600

HPA

ENSG00000163600-ICOS

GeneCards

Q9Y6W8

Ensembl

ENST00000435193, ENSG00000163600, ENSP00000415951, ENSP00000319476, ENST00000316386

PRO

Q9Y6W8

Pharos - Targets

Q9Y6W8

Orphanet

16238

PDB

7JOO, 6X4G

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75144 ICOSLG	1	ICOSLG [plasma membrane] (R-HSA-197910)	0.733	8
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.623	5
UniProt:Q9UHD2 TBK1	5	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.499	5

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