Reactome | ACTN4 [platelet alpha granule lumen]

ACTN4 [platelet alpha granule lumen]

Stable Identifier

R-HSA-198240

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

Alpha-actinin 4

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O43707 ACTN4

Gene Names

ACTN4

Chain

chain:1-911

Reference Genes

BioGPS Gene:81 ACTN4

COSMIC (genes):ACTN4 ACTN4

CTD Gene:81 ACTN4

dbSNP Gene:81 ACTN4

ENSEMBL:ENSG00000130402 ACTN4

ENSEMBL:ENSG00000282844 ACTN4

ENSEMBL_homo_sapiens_GENE:ENSG00000130402.14 ACTN4

ENSEMBL_homo_sapiens_GENE:ENSG00000282844.2 ACTN4

HGNC:166 ACTN4

KEGG Gene (Homo sapiens):81 ACTN4

Monarch:81 ACTN4

NCBI Gene:81 ACTN4

OMIM:604638 ACTN4

UCSC:O43707 ACTN4

Reference Transcript

RefSeq:NM_004924.5 ACTN4

Other Identifiers

11715861_a_at

11747073_a_at

11747074_x_at

11747454_a_at

11753902_a_at

16861852

200601_PM_at

200601_at

2740728

2740731

2740759

2740761

3832644

3832645

3832646

3832683

3832684

3832685

3832686

3832688

3832689

3832690

3832693

3832694

3832695

3832697

3832699

3832702

3832703

3832706

3832707

3832708

3832711

3832714

3832719

3832720

3832721

3832722

3832723

3832725

41753_at

55075_at

57962_at

8028524

A_23_P101655

A_23_P315241

GE80030

GE865997

GO:0000977

GO:0001725

GO:0001882

GO:0003677

GO:0003713

GO:0003723

GO:0003779

GO:0005178

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005856

GO:0005886

GO:0005925

GO:0006351

GO:0006355

GO:0007010

GO:0007155

GO:0008092

GO:0012501

GO:0015031

GO:0015629

GO:0016922

GO:0023052

GO:0030018

GO:0030036

GO:0030050

GO:0030054

GO:0030154

GO:0030335

GO:0030374

GO:0030864

GO:0031093

GO:0031143

GO:0031410

GO:0031490

GO:0032417

GO:0032991

GO:0033209

GO:0035357

GO:0042803

GO:0042974

GO:0042981

GO:0042995

GO:0043226

GO:0044325

GO:0045944

GO:0046872

GO:0048384

GO:0048471

GO:0048856

GO:0048870

GO:0051015

GO:0055001

GO:0055085

GO:0070062

GO:0070161

GO:0140110

GO:1900025

GO:1901224

GO:1990904

HMNXSV003011844

ILMN_1725534

PH_hs_0025909

TC19000532.hg

g3157975_3p_at

Participates

as a member of

Alpha actinins [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

ACTN4 [cytosol]

ACTN4 [extracellular region]

Inferred To

ain1 [platelet alpha granule lumen] (Schizosaccharomyces pombe)

atn-1 [platelet alpha granule lumen] (Caenorhabditis elegans)

Homologues of ACTN4 [platelet alpha granule lumen] (Dictyostelium discoideum)

Homologues of ACTN4 [platelet alpha granule lumen] (Drosophila melanogaster)

LGALS7B [platelet alpha granule lumen] (Canis familiaris)

abpD [platelet alpha granule lumen] (Dictyostelium discoideum)

actn4 [platelet alpha granule lumen] (Xenopus tropicalis)

ACTN4 [platelet alpha granule lumen] (Bos taurus)

ACTN4 [platelet alpha granule lumen] (Dictyostelium discoideum)

ACTN4 [platelet alpha granule lumen] (Drosophila melanogaster)

ACTN4 [platelet alpha granule lumen] (Gallus gallus)

ACTN4 [platelet alpha granule lumen] (Mus musculus)

ACTN4 [platelet alpha granule lumen] (Rattus norvegicus)

ACTN4 [platelet alpha granule lumen] (Sus scrofa)

Cross References

RefSeq

NP_004915.2

OpenTargets

ENSG00000130402

GeneCards

O43707

HPA

ENSG00000130402-ACTN4

Ensembl

ENST00000252699, ENSP00000489220, ENST00000634692, ENSP00000252699, ENSG00000282844, ENST00000390009, ENST00000634960, ENSP00000439497, ENSP00000488962, ENSG00000130402

PRO

O43707

Pharos - Targets

O43707

Orphanet

15077

PDB

2R0O, 6OA6, 6O31, 1WLX, 1YDI

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.68	7
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	19
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.602	4
UniProt:Q07157 TJP1	5	TJP1 [cell junction] (R-HSA-8936023) TJP1 (?-?) [plasma membrane] (R-HSA-3209844) TJP1 [plasma membrane] (R-HSA-3209845) TJP1 [Golgi-associated vesicle membrane] (R-HSA-3209843) TJP1 [cytosol] (R-HSA-532659)	0.599	4
UniProt:O60294 LCMT2	1	LCMT2 [cytoplasm] (R-HSA-6782869)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P12830 CDH1	8	CDH1(732-882) [plasma membrane] (R-HSA-3827997) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(701-882) [extracellular region] (R-HSA-2534158) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) CDH1(155-750) [plasma membrane] (R-HSA-202940) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-882) [plasma membrane] (R-HSA-198003)	0.499	2
UniProt:P0DTC6 6	4	6 [nuclear envelope] (R-COV-9727279) 6 [cytosol] (R-COV-9708916) 6 [endoplasmic reticulum membrane] (R-COV-9727295) 6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705293)	0.482	2

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