PI3K produces PIP3 and other phosphatidyl inositides

Stable Identifier
R-HSA-198266
Type
Reaction
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
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PI3K produces PIP3 and other phosphatidyl inositides
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PI3-kinase phosphorylates several phosphatidyl-inositides (phospholipids) at the plasma membrane: the most relevant is PtdIns(3,4,5)P3, also named PIP3.

Literature References
PubMed ID Title Journal Year
12167717 Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

Woodgett, JR, Scheid, MP, Marignani, PA

Mol Cell Biol 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane]

Physical Entity
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
Orthologous Events
PI3K produces PIP3 and other phosphatidyl inositides (Bos taurus)
PI3K produces PIP3 and other phosphatidyl inositides (Canis familiaris)
PI3K produces PIP3 and other phosphatidyl inositides (Danio rerio)
PI3K produces PIP3 and other phosphatidyl inositides (Drosophila melanogaster)
PI3K produces PIP3 and other phosphatidyl inositides (Gallus gallus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)
PI3K produces PIP3 and other phosphatidyl inositides (Sus scrofa)
PI3K produces PIP3 and other phosphatidyl inositides (Xenopus tropicalis)
Cross References
Rhea
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
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