PDPK1 phosphorylates AKT at T308

Stable Identifier
R-HSA-198270
Type
Reaction
Species
Homo sapiens
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Once AKT is localized at the plasma membrane, it is phosphorylated at two critical residues for its full activation. These residues are a threonine (T308 in AKT1) in the activation loop within the catalytic domain, and a serine (S473 in AKT1), in a hydrophobic motif (HM) within the carboxy terminal, non-catalytic region. PDPK1 (PDK1) is the activation loop kinase; this kinase can also directly phosphorylate p70S6K. The HM kinase, previously termed PDK2, has been identified as the mammalian TOR (Target Of Rapamycin; Sarbassov et al., 2005) but several other kinases are also able to phosphorylate AKT at S473. Phosphorylation of AKT at S473 by TORC2 complex is a prerequisite for PDPK1-mediated phosphorylation of AKT threonine T308 (Scheid et al. 2002, Sarabassov et al. 2005).

Literature References
PubMed ID Title Journal Year
9736715 Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

Rue, L, Woodgett, J, Dedhar, S, Gray, V, Delcommenne, M, Tan, C

Proc Natl Acad Sci U S A 1998
7637810 Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

Coffer, PJ, Burgering, BM

Nature 1995
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Event Information
Catalyst Activity

protein serine/threonine kinase activity of p-S-AKT:PDPK1:PIP3 [plasma membrane]

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