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IRS1,2 [cytosol]
Stable Identifier
R-HSA-198273
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
JAK2 phosphorylation of IRS-1/2 (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-7 signaling (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Leptin (Homo sapiens)
JAK2 Phosphorylates IRS in Response to Leptin (Homo sapiens)
LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane] (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane] (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS activation (Homo sapiens)
Binding of IRS to insulin receptor (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
Phosphorylation of IRS (Homo sapiens)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
Signal attenuation (Homo sapiens)
Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
PI3K/AKT activation (Homo sapiens)
Active TRKA binds IRS1/2 (Homo sapiens)
Activated TrkA receptor:IRS1/2 [plasma membrane] (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
TRKA phosphorylates IRS (Homo sapiens)
Activated TrkA receptor:IRS1/2 [plasma membrane] (Homo sapiens)
IRS1,2 [cytosol] (Homo sapiens)
General
The proteins mentioned here are examples of IRS family members acting as indicated for IRS.
Participants
members
IRS2 [cytosol]
(Homo sapiens)
IRS1 [cytosol]
(Homo sapiens)
Participates
as a component of
LEP:p-LEPR:p-JAK2:SH2B1:IRS1,2 [plasma membrane] (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits:IRS1,IRS2 [plasma membrane] (Homo sapiens)
IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Homo sapiens)
Activated TrkA receptor:IRS1/2 [plasma membrane] (Homo sapiens)
as an input of
Phosphorylated LEP:LEPR:JAK2:SH2B1 Binds IRS1/2 (Homo sapiens)
IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3:PI3K-regulatory subunits binds IRS1,IRS2 (Homo sapiens)
JAK2 phosphorylation of IRS-1/2 (Homo sapiens)
Binding of IRS to insulin receptor (Homo sapiens)
Active TRKA binds IRS1/2 (Homo sapiens)
as an output of
Dephosphorylation of p-Y-IRS1,p-Y-IRS2 (Homo sapiens)
Inferred To
IRS1 [cytosol]
(Gallus gallus)
chico [cytosol]
(Drosophila melanogaster)
IRS1,2 [cytosol]
(Bos taurus)
IRS1,2 [cytosol]
(Canis familiaris)
IRS1,2 [cytosol]
(Mus musculus)
IRS1,2 [cytosol]
(Rattus norvegicus)
IRS1,2 [cytosol]
(Sus scrofa)
IRS1,2 [cytosol]
(Xenopus tropicalis)
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