AKT phosphorylates targets in the cytosol

Stable Identifier
R-HSA-198323
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT phosphorylates targets in the cytosol
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Following activation, AKT can phosphorylate an array of target proteins in the cytoplasm, many of which are involved in cell survival control. Phosphorylation of TSC2 feeds positively to the TOR kinase, which, in turn, contributes to AKT activation (positive feedback loop).

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Event Information
Go Biological Process
protein kinase B signaling (0043491)
Orthologous Events
AKT phosphorylates targets in the cytosol (Caenorhabditis elegans)
AKT phosphorylates targets in the cytosol (Canis familiaris)
AKT phosphorylates targets in the cytosol (Danio rerio)
AKT phosphorylates targets in the cytosol (Dictyostelium discoideum)
AKT phosphorylates targets in the cytosol (Drosophila melanogaster)
AKT phosphorylates targets in the cytosol (Gallus gallus)
AKT phosphorylates targets in the cytosol (Mus musculus)
AKT phosphorylates targets in the cytosol (Rattus norvegicus)
AKT phosphorylates targets in the cytosol (Saccharomyces cerevisiae)
AKT phosphorylates targets in the cytosol (Schizosaccharomyces pombe)
Cross References
BioModels Database
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-06-11)
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