Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
AKT phosphorylates targets in the cytosol
Stable Identifier
R-HSA-198323
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this pathway in the Pathway Browser
Following activation, AKT can phosphorylate an array of target proteins in the cytoplasm, many of which are involved in cell survival control. Phosphorylation of TSC2 feeds positively to the TOR kinase, which, in turn, contributes to AKT activation (positive feedback loop).
Participants
Events
AKT phosphorylates BAD
(Homo sapiens)
AKT phosphorylates GSK3
(Homo sapiens)
AKT phosphorylates caspase-9
(Homo sapiens)
AKT phosphorylates MDM2
(Homo sapiens)
AKT phosphorylates IKKalpha
(Homo sapiens)
AKT phosphorylates p21Cip1 and p27Kip1
(Homo sapiens)
AKT phosphorylates TSC2, inhibiting it
(Homo sapiens)
AKT phosphorylates AKT1S1 (PRAS40)
(Homo sapiens)
AKT phosphorylates MKRN1
(Homo sapiens)
Participates
as an event of
PIP3 activates AKT signaling (Homo sapiens)
Event Information
Go Biological Process
phosphatidylinositol 3-kinase/protein kinase B signal transduction (0043491)
Orthologous Events
AKT phosphorylates targets in the cytosol (Caenorhabditis elegans)
AKT phosphorylates targets in the cytosol (Danio rerio)
AKT phosphorylates targets in the cytosol (Dictyostelium discoideum)
AKT phosphorylates targets in the cytosol (Drosophila melanogaster)
AKT phosphorylates targets in the cytosol (Gallus gallus)
AKT phosphorylates targets in the cytosol (Mus musculus)
AKT phosphorylates targets in the cytosol (Rattus norvegicus)
AKT phosphorylates targets in the cytosol (Schizosaccharomyces pombe)
Cross References
BioModels Database
BIOMD0000000883
,
BIOMD0000000654
,
BIOMD0000000656
,
BIOMD0000000581
,
BIOMD0000000582
,
BIOMD0000000653
,
BIOMD0000000648
,
BIOMD0000000652
,
BIOMD0000000655
,
BIOMD0000000943
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
Jassal, B (2007-06-11)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text