Reactome | p-Y-IRS2 [plasma membrane]

p-Y-IRS2 [plasma membrane]

Stable Identifier

R-HSA-198334

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

pY-IRS2, p-IRS2, Phospho-IRS2 (by TRKA)

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - PI3K/AKT Signaling in Cancer (Homo sapiens)
    - Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
      - PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
        
        PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Homo sapiens)
        
        p-Y-IRS2 [plasma membrane] (Homo sapiens)
        
        PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Homo sapiens)
        
        p-Y-IRS2 [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
        
        Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Homo sapiens)
        
        p-Y-IRS2 [plasma membrane] (Homo sapiens)
    - PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
      - Activator:PI3K [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Homo sapiens)
        
        Phospho-IRS1/2 (by TRKA) [plasma membrane] (Homo sapiens)
        
        p-Y-IRS2 [plasma membrane] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
    - IGF1R signaling cascade (Homo sapiens)
      - IRS-related events triggered by IGF1R (Homo sapiens)
        
        IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 (Homo sapiens)
        
        IGF1,2:p-IGF1R:p-IRS1,2,4 [plasma membrane] (Homo sapiens)
        
        p-IRS1,2,4 [plasma membrane] (Homo sapiens)
        
        p-Y-IRS2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y4H2 IRS2

Gene Names

IRS2

Chain

chain:1-1338

Reference Genes

BioGPS Gene:8660 IRS2

COSMIC (genes):IRS2 IRS2

CTD Gene:8660 IRS2

dbSNP Gene:8660 IRS2

ENSEMBL:ENSG00000185950 IRS2

ENSEMBL_homo_sapiens_GENE:ENSG00000185950.9 IRS2

HGNC:6126 IRS2

KEGG Gene (Homo sapiens):8660 IRS2

Monarch:8660 IRS2

NCBI Gene:8660 IRS2

OMIM:600797 IRS2

UCSC:Q9Y4H2 IRS2

Reference Transcript

RefSeq:NM_003749.2 IRS2

Other Identifiers

11718012_at

11718013_at

16780917

209184_PM_s_at

209184_s_at

209185_PM_s_at

209185_s_at

3525236

3525237

3525238

3525239

3525240

3525241

3525242

3525243

3525259

3525260

3525261

3525262

3525263

3525264

3525265

3525266

3525267

3525268

3525269

3525270

3525271

3525272

3525273

3525274

3525275

3525276

40180_at

48795_at

56338_at

7972745

8660

A_24_P154037

A_24_P207003

GO:0002053

GO:0002376

GO:0002903

GO:0005068

GO:0005158

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0005975

GO:0006006

GO:0006091

GO:0006629

GO:0007165

GO:0007420

GO:0008283

GO:0008284

GO:0008286

GO:0009749

GO:0010631

GO:0010634

GO:0010748

GO:0010907

GO:0012501

GO:0016477

GO:0019216

GO:0019901

GO:0019903

GO:0019904

GO:0023052

GO:0030674

GO:0030879

GO:0030890

GO:0032000

GO:0032024

GO:0032869

GO:0033673

GO:0043548

GO:0044342

GO:0045725

GO:0046326

GO:0048856

GO:0048870

GO:0051897

GO:0055085

GO:0055088

GO:0060090

GO:0071333

GO:0071889

GO:0141038

GO:1901653

GO:1904692

HMNXSV003028001

Hs.143648.0.S2_3p_a_at

ILMN_2083469

PH_hs_0008458

TC13000871.hg

g4511968_3p_a_at

Participates

as a member of

Other forms of this molecule

IRS2 [plasma membrane]

IRS2 [cytosol]

p-Y-IRS2 [cytosol]

Inferred To

phospho-chico [plasma membrane] (Drosophila melanogaster)

phospho-IRS2 [plasma membrane] (Bos taurus)

phospho-IRS2 [plasma membrane] (Canis familiaris)

phospho-IRS2 [plasma membrane] (Sus scrofa)

phospho-LOC100498409 [plasma membrane] (Xenopus tropicalis)

phospho-Irs2 [plasma membrane] (Mus musculus)

phospho-Irs2 [plasma membrane] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_003740.2

OpenTargets

ENSG00000185950

GeneCards

Q9Y4H2

HPA

ENSG00000185950-IRS2

Ensembl

ENST00000375856, ENSP00000365016, ENSG00000185950

PRO

Q9Y4H2

Pharos - Targets

Q9Y4H2

PDB

3FQX, 3FQW

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.862	9
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.826	7
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.816	6
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.802	8
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.763	6
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.688	3
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.589	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.569	4
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	4
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.527	4
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.527	2