AKT phosphorylates BAD

Stable Identifier
R-HSA-198347
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT phosphorylates BAD
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Activated AKT phosphorylates the BCL-2 family member BAD at serine 99 (corresponds to serine residue S136 of mouse Bad), blocking the BAD-induced cell death (Datta et al. 1997, del Peso et al. 1997, Khor et al. 2004).
Literature References
PubMed ID Title Journal Year
15183529 Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 15183529

Khor, TO, Gul, YA, Ithnin, H, Seow, HF

Cancer Lett 2004
9346240 Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

Datta, SR, Dudek, H, Tao, X, Masters, S, Fu, H, Gotoh, Y, Greenberg, ME

Cell 1997
9381178 Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

del Peso, L, Gonzalez-Garcia, M, Page, CP, Herrera, R, Nunez, G

Science 1997
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Output
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Event Information
Go Biological Process
phosphatidylinositol 3-kinase/protein kinase B signal transduction (0043491)
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]

Physical Entity
p-T,p-S-AKT [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
AKT phosphorylates Bad (Homo sapiens)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-06-11)
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