12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region]

Stable Identifier
R-HSA-1983677
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
NOTCH4 Extracellular fragment (NECD4)
Icon
12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region] icon
12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q99466 NOTCH4
Gene Names
NOTCH4, INT3
Chain
signal peptide:1-23, chain:24-2003, chain:1432-2003, chain:1467-2003
Reference Genes
BioGPS Gene:4855 NOTCH4
COSMIC (genes):NOTCH4 NOTCH4
CTD Gene:4855 NOTCH4
dbSNP Gene:4855 NOTCH4
ENSEMBL:ENSG00000204301 NOTCH4
HGNC:7884 NOTCH4
KEGG:hsa:4855 NOTCH4
Monarch:4855 NOTCH4
NCBI Gene:4855 NOTCH4
OMIM:164951 NOTCH4
UCSC:Q99466 NOTCH4
Reference Transcript
Other Identifiers
11721965_a_at
11746752_a_at
11748539_a_at
11751705_a_at
17017814
17027038
17029639
17034630
17037128
17039839
17042335
205247_PM_at
205247_at
240786_PM_at
240786_at
2949899
2949900
2949902
2949903
2949904
2949905
2949906
2949907
2949908
2949909
2949911
2949912
2949913
2949914
2949915
2949916
2949917
2949918
2949919
2949920
2949921
2949922
2949923
2949924
2949925
2949926
2949927
2949928
2949929
2949931
2949932
2949933
2949934
2949935
2949936
2949937
2949939
2949940
2949941
2949942
2949943
2949944
2949945
2949946
2949947
2949949
2949950
2949952
2949954
2949955
2949956
2949957
2949958
2949959
2949960
2949962
39048_at
4855
57139_at
8125383
A_23_P365614
A_24_P26496
GE59595
GO:0000122
GO:0000139
GO:0000987
GO:0001228
GO:0001569
GO:0001709
GO:0001763
GO:0001837
GO:0001944
GO:0003677
GO:0005112
GO:0005509
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005783
GO:0005789
GO:0005829
GO:0005886
GO:0006355
GO:0007219
GO:0007221
GO:0007275
GO:0009986
GO:0016020
GO:0030097
GO:0030154
GO:0030879
GO:0038023
GO:0042060
GO:0043226
GO:0045596
GO:0045602
GO:0045893
GO:0045944
GO:0046872
GO:0048589
GO:0048856
GO:0050793
GO:0051152
GO:0060089
GO:0060354
GO:0140110
GO:2000048
HMNXSV003054488
Hs.11689.0.S2_3p_at
Hs.224880.0.A1_3p_at
ILMN_1711157
PH_hs_0025474
TC06001564.hg
TC6_apd_hap1000098.hg
TC6_cox_hap2000190.hg
TC6_mann_hap4000155.hg
TC6_mcf_hap5000165.hg
TC6_qbl_hap6000179.hg
TC6_ssto_hap7000159.hg
U89335_cds2_at
Participates
as a component of
Other forms of this molecule
NOTCH4(1432-1466) [plasma membrane]
NEXT4 [plasma membrane]
p-4S-NICD4 [cytosol]
NICD4 [cytosol]
p-NICD4 [nucleoplasm]
PolyUb-p-NICD4 [nucleoplasm]
NOTCH4(1337-2003) [Golgi membrane]
12xFucT-8xGlcS-6xFucS-NOTCH4(24-1336) [Golgi membrane]
NOTCH4(1337-2003) [plasma membrane]
12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) [Golgi membrane]
12xFucT-8xGlcS-6xFucS-NOTCH4(24-2003) [endoplasmic reticulum membrane]
12xFucT-6xFucS-NOTCH4(24-2003) [endoplasmic reticulum membrane]
Pre-NOTCH4 [endoplasmic reticulum membrane]
FRINGE-modified NOTCH4 Extracellular fragment (NECD4) [Golgi membrane]
FRINGE-modified NOTCH4 Extracellular Fragment (NECD4) [plasma membrane]
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]
Glc,GlcNAc-Fuc-Pre-NOTCH4 [Golgi membrane]
NICD4 [nucleoplasm]
Inferred To
Homologues of 12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region] (Caenorhabditis elegans)
Homologues of 12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region] (Drosophila melanogaster)
Ser [extracellular region] (Drosophila melanogaster)
lin-12 [extracellular region] (Caenorhabditis elegans)
12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region] (Bos taurus)
12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region] (Caenorhabditis elegans)
12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region] (Gallus gallus)
12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region] (Rattus norvegicus)
12xFucT-11xGlcS-6xFucS-NOTCH4(24-1336) [extracellular region] (Sus scrofa)
crb [extracellular region] (Drosophila melanogaster)
Notch4 [extracellular region] (Mus musculus)
C901 [extracellular region] (Drosophila melanogaster)
Modified Residues
Name
O-fucosyl-L-threonine at 40
Coordinate
40
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-serine at 79
Coordinate
79
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Name
O-fucosyl-L-serine at 210
Coordinate
210
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Name
O-fucosyl-L-threonine at 248
Coordinate
248
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 290
Coordinate
290
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 331
Coordinate
331
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 369
Coordinate
369
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-serine at 451
Coordinate
451
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Name
O-fucosyl-L-threonine at 489
Coordinate
489
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-serine at 603
Coordinate
603
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Name
O-fucosyl-L-threonine at 705
Coordinate
705
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-serine at 743
Coordinate
743
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Name
O-fucosyl-L-threonine at 781
Coordinate
781
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 820
Coordinate
820
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 944
Coordinate
944
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 982
Coordinate
982
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-threonine at 1060
Coordinate
1060
PsiMod Name
O-fucosyl-L-threonine
PsiMod Definition
A protein modification that effectively converts an threonine residue to an O-fucosylthreonine.
Name
O-fucosyl-L-serine at 1145
Coordinate
1145
PsiMod Name
O-fucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to an O-fucosylserine.
Name
O-glucosyl-L-serine at 398
Coordinate
398
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Name
O-glucosyl-L-serine at 481
Coordinate
481
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Name
O-glucosyl-L-serine at 519
Coordinate
519
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Name
O-glucosyl-L-serine at 557
Coordinate
557
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Name
O-glucosyl-L-serine at 595
Coordinate
595
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Name
O-glucosyl-L-serine at 697
Coordinate
697
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Name
O-glucosyl-L-serine at 735
Coordinate
735
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Name
O-glucosyl-L-serine at 773
Coordinate
773
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Name
O-glucosyl-L-serine at 936
Coordinate
936
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Name
O-glucosyl-L-serine at 974
Coordinate
974
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Name
O-glucosyl-L-serine at 1052
Coordinate
1052
PsiMod Name
O-glucosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-beta-glucosylated L-serine.
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
HPA
ZINC - Substances
ZINC target
PRO
Pharos - Targets
ZINC - Predictions - Purchasable
PDB
Interactors (1)
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