AKT phosphorylates GSK3

Stable Identifier
R-HSA-198371
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT phosphorylates GSK3
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GSK3 (glycogen synthase kinase-3) participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, and the transcription factors MYB and JUN. GSK3 phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. GSK3 is inhibited when phosphorylated by AKT1.

Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
protein kinase B signaling (0043491)
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]

Physical Entity
p-T,p-S-AKT [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Akt1 phosphorylates GSK3 (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-06-11)
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