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AKT phosphorylates GSK3
Stable Identifier
R-HSA-198371
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
AKT phosphorylates GSK3 (Homo sapiens)
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GSK3 (glycogen synthase kinase-3) participates in the Wnt signaling pathway. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, and the transcription factors MYB and JUN. GSK3 phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. GSK3 is inhibited when phosphorylated by AKT1.
Participants
Input
ATP [cytosol]
GSK3 [cytosol]
(Homo sapiens)
Output
ADP [cytosol]
p-S9/21-GSK3 [cytosol]
(Homo sapiens)
Participates
as an event of
AKT phosphorylates targets in the cytosol (Homo sapiens)
Event Information
Go Biological Process
phosphatidylinositol 3-kinase/protein kinase B signal transduction (0043491)
Catalyst Activity
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
Physical Entity
p-T,p-S-AKT [cytosol]
(Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Akt1 phosphorylates GSK3 (Rattus norvegicus)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
Jassal, B (2007-06-11)
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