AKT phosphorylates IKKalpha

Stable Identifier
R-HSA-198611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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AKT mediates IKKalpha (Inhibitor of nuclear factor kappa B kinase subunit alpha) phosphorylation at threonine 23, which is required for NF-kB activation. NF-kB promoted gene transcription enhances neuronal survival.
Literature References
PubMed ID Title Journal Year
10485710 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

Donner, DB, Mayo, LD, Pfeffer, SR, Pfeffer, LM, Ozes, ON, Gustin, JA

Nature 1999
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Event Information
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Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]

Orthologous Events
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