AKT phosphorylates IKKalpha

Stable Identifier
R-HSA-198611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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AKT phosphorylates IKKalpha
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AKT mediates IKKalpha (Inhibitor of nuclear factor kappa B kinase subunit alpha) phosphorylation at threonine 23, which is required for NF-kB activation. NF-kB promoted gene transcription enhances neuronal survival.
Literature References
PubMed ID Title Journal Year
10485710 NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

Donner, DB, Mayo, LD, Pfeffer, SR, Pfeffer, LM, Ozes, ON, Gustin, JA

Nature 1999
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
phosphatidylinositol 3-kinase/protein kinase B signal transduction (0043491)
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]

Physical Entity
p-T,p-S-AKT [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AKT phosphorylates IKKalpha (Danio rerio)
AKT phosphorylates IKKalpha (Drosophila melanogaster)
AKT phosphorylates IKKalpha (Gallus gallus)
AKT phosphorylates IKKalpha (Mus musculus)
AKT phosphorylates IKKalpha (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-06-29)
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