Phosphorylation of p27Kip1 at T157 and of p21Cip1 at T145 by AKT leads to their retention in the cytoplasm, segregating these cyclin-dependent kinase (CDK) inhibitors from cyclin-CDK complexes.
Xia, W, Liao, Y, Hung, MC, Zhou, BP, Lee, MH, Spohn, B
Tsichlis, P, Viglietto, G, Santoro, M, Bruni, P, Vinci, F, Motti, ML, Califano, D, Fusco, A, Chiappetta, G, Melillo, RM, D'Alessio, A, Bellacosa, A
protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
© 2023 Reactome
