Reactome | AKT phosphorylates p21Cip1 and p27Kip1

AKT phosphorylates p21Cip1 and p27Kip1

Stable Identifier

R-HSA-198613

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Phosphorylation of p27Kip1 at T157 and of p21Cip1 at T145 by AKT leads to their retention in the cytoplasm, segregating these cyclin-dependent kinase (CDK) inhibitors from cyclin-CDK complexes.

Literature References

PubMed ID	Title	Journal	Year
11231573	Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells Xia, W, Liao, Y, Hung, MC, Zhou, BP, Lee, MH, Spohn, B	Nat. Cell Biol.	2001
12244303	Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer Tsichlis, P, Viglietto, G, Santoro, M, Bruni, P, Vinci, F, Motti, ML, Califano, D, Fusco, A, Chiappetta, G, Melillo, RM, D'Alessio, A, Bellacosa, A	Nat Med	2002