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MAP2K5 [cytosol]
Stable Identifier
R-HSA-198722
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MEK5, MPK5_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9Y2U5 M3K2
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERK5 (Homo sapiens)
ERK5 is activated (Homo sapiens)
MAP2K5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13163 MAP2K5
Gene Names
MAP2K5, MEK5, MKK5, PRKMK5
Chain
chain:1-448
Reference Genes
BioGPS Gene:5607 MAP2K5
COSMIC (genes):MAP2K5 MAP2K5
CTD Gene:5607 MAP2K5
dbSNP Gene:5607 MAP2K5
ENSEMBL:ENSG00000137764 MAP2K5
HGNC:6845 MAP2K5
KEGG:hsa:5607 MAP2K5
Monarch:5607 MAP2K5
NCBI Gene:5607 MAP2K5
OMIM:602520 MAP2K5
UCSC:Q13163 MAP2K5
Reference Transcript
RefSeq:NM_002757.3 MAP2K5
RefSeq:NM_001206804.1 MAP2K5
RefSeq:NM_145160.2 MAP2K5
Other Identifiers
11719312_a_at
11763807_at
16802326
1698_g_at
1722_at
204756_PM_at
204756_at
210482_PM_x_at
210482_x_at
211370_PM_s_at
211370_s_at
3599163
3599164
3599165
3599166
3599168
3599174
3599177
3599178
3599180
3599181
3599186
3599191
3599194
3599195
3599196
3599197
3599198
3599199
3599202
3599203
3599204
3599208
3599210
3599211
3599212
3599218
3599226
3599227
3599228
3599238
3599239
3599240
3599241
3599259
3599260
3599261
3599262
3599263
41230_at
513_at
5607
7984408
A_14_P129239
A_23_P84256
A_24_P356130
GE62483
GO:0000122
GO:0000165
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004713
GO:0005515
GO:0005524
GO:0005819
GO:0006355
GO:0006468
GO:0007165
GO:0007507
GO:0016740
GO:0030307
GO:0032717
GO:0034115
GO:0034392
GO:0043124
GO:0043226
GO:0045944
GO:0046872
GO:0048009
GO:0048856
GO:0050679
GO:0051247
GO:0060761
GO:0070375
GO:0071363
GO:0071499
GO:0090051
GO:0106310
GO:0140096
GO:2000342
GO:2001240
HMNXSV003015106
ILMN_1710943
ILMN_1718129
ILMN_2391891
PH_hs_0020481
TC15000625.hg
U25265_at
U71087_at
g1616778_3p_a_at
g4506100_3p_at
p27248
Cross References
RefSeq
NP_660143.1
,
NP_001193733.1
,
NP_002748.1
ZINC - World Drugs
MP2K5_HUMAN
Guide to Pharmacology - Targets
2066
OpenTargets
ENSG00000137764
ENSEMBL
ENSP00000178640
,
ENSP00000378859
,
ENST00000354498
,
ENST00000178640
,
ENST00000395476
,
ENSP00000346493
ZINC - FDA approved
MP2K5_HUMAN
ZINC - Substances
MP2K5_HUMAN
ZINC - Biogenic
MP2K5_HUMAN
ZINC target
Q13163
PRO
Q13163
PDB
4IC7
,
2NPT
,
2O2V
ZINC - Investigational
MP2K5_HUMAN
HPA
ENSG00000137764-MAP2K5
Pharos - Targets
Q13163
ZINC - Predictions - Purchasable
MP2K5_HUMAN
HMDB Protein
HMDBP08760
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13164 MAPK7
4
p-T218,Y221-MAPK7 [nucleoplasm]
(R-HSA-198738)
p-T218,Y221-MAPK7 [cytosol]
(R-HSA-198721)
MAPK7 [cytosol]
(R-HSA-198754)
MAPK7 [nucleoplasm]
(R-HSA-199961)
0.863
8
UniProt:Q9Y2U5 M3K2
0.798
7
UniProt:Q99759 MAP3K3
1
MAP3K3 [cytosol]
(R-HSA-507725)
0.731
5
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.669
4
UniProt:Q8N448 LNX2
0.668
3
UniProt:Q13501 SQSTM1
7
SQSTM1 [cytosol]
(R-HSA-193937)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
0.666
5
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.643
4
UniProt:Q6ZNG0 ZNF620
1
ZNF620 [nucleoplasm]
(R-HSA-2127603)
0.556
3
UniProt:Q3SXR2 CC036
0.556
3
UniProt:Q99471 PFDN5
1
PFDN5 [cytosol]
(R-HSA-379548)
0.556
3
UniProt:Q9BUY5 ZNF426
1
ZNF426 [nucleoplasm]
(R-HSA-1247530)
0.556
3
UniProt:Q9H596 DUS21
0.556
3
UniProt:Q96NT3-2 GUCD1
0.556
3
UniProt:P07900 HSP90AA1
8
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
0.527
3
UniProt:Q9H8K7 PAAT
0.527
2
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