Reactome | SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol

SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol

Stable Identifier

R-HSA-198870

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Ascorbate transport across the plasma membrane, ascorbate [extracellular] + 2 Na+ [extracellular] => ascorbate [cytosol] + 2 Na+ [cytosol]

ReviewStatus

5/5

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SLC23A1,2 cotransports AscH-, 2Na+ from extracellular region to cytosol

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The plasma membrane-associated transport proteins SVCT1 and SVCT2 (encoded by SLC23A1 and SLC23A2 respectively) are each capable of mediating the uptake of one molecule of ascorbate (AscH-) and two sodium ions from the extracellular space to the cytosol (Daruwala et al. 1999, Rajan et al. 1999, Wang et al. 1999). In the body SVCT2 is expressed in most tissues, while SVCT1 is largely confined to epithelial cells (Liang et al. 2001). SVCT2 may mediate fetal uptake of ascorbate from the maternal circulation (Rajan et al. 1999). The transporters responsible for its uptake from the small intestine and for its release from enterocytes into the circulation have not been identified, although both SVCT1 and 2 are expressed in intestinal cells.

Literature References

PubMed ID	Title	Journal	Year
10556483	Human Na+-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant Wang, H, Dutta, B, Huang, W, Devoe, LD, Leibach, FH, Ganapathy, V, Prasad, PD	Biochim Biophys Acta	1999
10471399	Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function Rajan, DP, Huang, W, Dutta, B, Devoe, LD, Leibach, FH, Ganapathy, V, Prasad, PD	Biochem Biophys Res Commun	1999
10556521	Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2 Daruwala, R, Song, J, Koh, WS, Rumsey, SC, Levine, M	FEBS Lett	1999
11396616	Vitamin C transport systems of mammalian cells Liang, W-J, Johnson, D, Jarvis, SM	Mol Membr Biol	2001