MADCAM1-1 binds Integrin alpha4beta7

Stable Identifier
R-HSA-199032
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Mucosal addressin cell adhesion molecule (MADCAM1) is present in the endothelium of mucosa, and binds alpha-4 beta-7 integrin and L-selectin, regulating both the passage and retention of leukocytes in mucosal tissues. MADCAM1 has been shown to be present as a homodimer.
Literature References
PubMed ID Title Journal Year
9700512 Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses

Springer, TA, Wang, J

Immunol Rev 1998
11807247 A reassessment of the MAdCAM-1 structure and its role in integrin recognition

King, DJ, Brady, RL, Dando, J, Ortlepp, S, Wilkinson, KW

Acta Crystallogr D Biol Crystallogr 2002
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