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MADCAM1-1 binds Integrin alpha4beta7
Stable Identifier
R-HSA-199032
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
MADCAM1-1 binds Integrin alpha4beta7 (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
MADCAM1-1 binds Integrin alpha4beta7 (Homo sapiens)
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Mucosal addressin cell adhesion molecule (MADCAM1) is present in the endothelium of mucosa, and binds alpha-4 beta-7 integrin and L-selectin, regulating both the passage and retention of leukocytes in mucosal tissues. MADCAM1 has been shown to be present as a homodimer.
Literature References
PubMed ID
Title
Journal
Year
9700512
Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses
Springer, TA
,
Wang, J
Immunol Rev
1998
11807247
A reassessment of the MAdCAM-1 structure and its role in integrin recognition
King, DJ
,
Brady, RL
,
Dando, J
,
Ortlepp, S
,
Wilkinson, KW
Acta Crystallogr D Biol Crystallogr
2002
Participants
Input
Integrin alpha4beta7 [plasma membrane]
(Homo sapiens)
x 2
MADCAM1-1 [plasma membrane]
(Homo sapiens)
Output
Integrin alpha4beta7:MADCAM1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Orthologous Events
MADCAM1-1 binds Integrin alpha4beta7 (Bos taurus)
MADCAM1-1 binds Integrin alpha4beta7 (Canis familiaris)
MADCAM1-1 binds Integrin alpha4beta7 (Mus musculus)
MADCAM1-1 binds Integrin alpha4beta7 (Rattus norvegicus)
MADCAM1-1 binds Integrin alpha4beta7 (Sus scrofa)
MADCAM1-1 binds Integrin alpha4beta7 (Xenopus tropicalis)
Authored
de Bono, B (2007-07-08)
Reviewed
Barrow, AD (2015-05-13)
Trowsdale, J (2007-08-06)
Created
de Bono, B (2007-07-08)
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