Reactome | PANK1/3 phosphorylate PanK

PANK1/3 phosphorylate PanK

Stable Identifier

R-HSA-199203

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+), Pantothenate is phosphorylated [PANK1;3;4]

ReviewStatus

5/5

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Cytosolic pantothenate kinases 1 and 3 (PANK1, PANK3) catalyze the reaction of ATP and pantothenate to form ADP and phosphopantothenate. This enzymatic activity has been demonstrated in crude cell extracts for two isoforms of mouse pantothenate kinase 1 (Rock et al. 2002) and for their human homologues (Ramaswamy and 2004). An additional human gene, PANK3, encodes a closely related protein but pantothenate kinase activity has not been demonstrated experimentally for it (Cavestro et al. 2023; Leonardi et al. 2005; Zhou et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
15893380	Coenzyme A: back in action Leonardi, R, Zhang, YM, Rock, CO, Jackowski, S	Prog Lipid Res	2005
12095677	The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes Rock, CO, Karim, MA, Zhang, YM, Jackowski, S	Gene	2002
11479594	A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome Zhou, B, Westaway, SK, Levinson, B, Johnson, MA, Gitschier, J, Hayflick, SJ	Nat Genet	2001
14523052	PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression Ramaswamy, G, Karim, MA, Murti, KG, Jackowski, S	J Lipid Res	2004
36983025	Inherited Disorders of Coenzyme A Biosynthesis: Models, Mechanisms, and Treatments Cavestro, C, Diodato, D, Tiranti, V, Di Meo, I	Int J Mol Sci	2023