Reactome | SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol

SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol

Stable Identifier

R-HSA-199219

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

biotin [extracellular] + 2 Na+ [extracellular] => biotin [cytosol] + 2 Na+ [cytosol]

ReviewStatus

5/5

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SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol

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The plasma membrane-associated transport protein SLC5A6 (aka sodium-dependent multivitamin transporter, SMVT) mediates the uptake of one molecule of biotin (Btn) and two sodium ions from the extracellular space to the cytosol. Limited Northern blotting studies suggest that SLC5A6 is widely expressed and abundant in placenta, liver and small intestine. SLC5A6 may thus play a central role in Btn uptake from dietary sources. SLC5A6 also mediates the uptake of pantothenate and lipoate (Prasad et al. 1999, Wang et al. 1999, Balamurugan et al. 2003). PDZ domain-containing protein 11 (PDZD11 aka AIPP1) is a cytosolic protein with a single PDZ domain which can bind to the C-terminal class 1 PDZ binding motif of SLC5A6, resulting in a significant induction of vitamin uptake over that with SLC5A6 alone (Nabokina et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
10329687	Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. Wang, H, Leibach, FH, Xia, H, Ganapathy, V, Yang-Feng, TL, Huang, W, Devoe, LD, Prasad, PD, Fei, YJ	J Biol Chem	1999
21183659	Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter Said, HM, Nabokina, SM, Subramanian, VS	Am. J. Physiol. Gastrointest. Liver Physiol.	2011
12646417	Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system Said, HM, Ortiz, A, Balamurugan, K	Am. J. Physiol. Gastrointest. Liver Physiol.	2003
10334869	Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter Wang, H, Leibach, FH, Ganapathy, V, Huang, W, Devoe, LD, Prasad, PD, Fei, YJ	Arch Biochem Biophys	1999