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FASN [cytosol]
Stable Identifier
R-HSA-199233
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
apo-FASN, Fatty acid synthase apoenzyme, EC 2.3.1.38, EC 2.3.1.39, EC 2.3.1.41, EC 1.1.1.100, EC 4.2.1.61, EC 1.3.1.10, EC 3.1.2.14
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Fatty Acid Synthase (FASN) (Homo sapiens)
FASN [cytosol] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Vitamin B5 (pantothenate) metabolism (Homo sapiens)
Phosphopantetheine conjugation of the ACP domain of FAS (Homo sapiens)
FASN [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis (Homo sapiens)
Expression of FASN regulated by NR1H2 or NR1H3 (Homo sapiens)
FASN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49327 FASN
Gene Names
FASN, FAS
Chain
chain:1-2511
Reference Genes
BioGPS Gene:2194 FASN
COSMIC (genes):FASN FASN
CTD Gene:2194 FASN
dbSNP Gene:2194 FASN
ENSEMBL:ENSG00000169710 FASN
ENSEMBL_homo_sapiens_GENE:ENSG00000169710.9 FASN
HGNC:3594 FASN
KEGG Gene (Homo sapiens):2194 FASN
Monarch:2194 FASN
NCBI Gene:2194 FASN
OMIM:600212 FASN
UCSC:P49327 FASN
Reference Transcript
RefSeq:NM_004104.4 FASN
RefSeq:XM_011523538.2 FASN
Other Identifiers
11743314_a_at
16850107
212218_PM_s_at
212218_s_at
217006_PM_x_at
217006_x_at
2194
2802091
3774634
3774636
3774637
3774639
3774641
3774642
3774643
3774645
3774647
3774649
3774650
3774651
3774652
3774653
3774655
3774657
3774658
3774659
3774660
3774661
3774662
3774663
3774664
3774666
3774667
3774668
3774669
3774670
3774671
3774672
3774673
3774674
3774677
3774678
3774679
3774680
3774681
3774682
3774683
3774684
3774685
3774686
3774687
3774688
3774689
3774690
3774693
3774694
3774698
38429_at
8019392
A_23_P44132
A_33_P3329344
GE59061
GO:0001649
GO:0002068
GO:0003723
GO:0003824
GO:0004312
GO:0004313
GO:0004314
GO:0004315
GO:0004316
GO:0004317
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005794
GO:0005829
GO:0005886
GO:0006629
GO:0006631
GO:0006633
GO:0006954
GO:0008152
GO:0008610
GO:0008611
GO:0008659
GO:0008693
GO:0009058
GO:0009888
GO:0016020
GO:0016295
GO:0016296
GO:0016297
GO:0016419
GO:0016491
GO:0016740
GO:0016746
GO:0016787
GO:0016829
GO:0019171
GO:0030154
GO:0030223
GO:0030224
GO:0030879
GO:0031177
GO:0031410
GO:0042470
GO:0042587
GO:0043226
GO:0044788
GO:0045296
GO:0047117
GO:0047450
GO:0047451
GO:0048856
GO:0070062
GO:0071353
GO:0090557
HMNXSV003010470
Hs.11050.2.A2_3p_s_at
Hs.83190.1.S1_3p_a_at
ILMN_1784871
PH_hs_0004753
S80437_s_at
TC17001973.hg
Participates
as an output of
Expression of FASN regulated by NR1H2 or NR1H3 (Homo sapiens)
Expression of Fatty Acid Synthase (FASN) (Homo sapiens)
as an input of
Phosphopantetheine conjugation of the ACP domain of FAS (Homo sapiens)
Other forms of this molecule
decanoyl-FASN [cytosol]
FASN [cytosol]
Inferred To
stlA [cytosol]
(Dictyostelium discoideum)
FASN [cytosol]
(Bos taurus)
FASN [cytosol]
(Canis familiaris)
FASN [cytosol]
(Gallus gallus)
FASN [cytosol]
(Mus musculus)
FASN [cytosol]
(Rattus norvegicus)
FASN [cytosol]
(Sus scrofa)
FASN1 [cytosol]
(Drosophila melanogaster)
Homologues of FASN [cytosol]
(Dictyostelium discoideum)
pks17 [cytosol]
(Dictyostelium discoideum)
fasn [cytosol]
(Xenopus tropicalis)
pks16 [cytosol]
(Dictyostelium discoideum)
fasn-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_011521840.1
,
NP_004095.4
ZINC - World Drugs
FAS_HUMAN
Guide to Pharmacology - Targets
2608
OpenTargets
ENSG00000169710
ZINC - FDA approved
FAS_HUMAN
ZINC - Substances
FAS_HUMAN
ZINC - Biogenic
FAS_HUMAN
ZINC target
P49327
PRO
P49327
PDB
2JFD
,
3TJM
,
8G7X
,
6NNA
,
1XKT
,
4W82
,
8EYI
,
4W9N
,
7MHD
,
5C37
,
2JFK
,
3HHD
,
4PIV
,
8EYK
,
7MHE
,
2PX6
,
8GKC
,
4Z49
,
2CG5
ZINC - Metabolites
FAS_HUMAN
GeneCards
P49327
HPA
ENSG00000169710-FASN
Ensembl
ENSG00000169710
,
ENST00000306749
,
ENSP00000304592
Pharos - Targets
P49327
ZINC - Predictions - Purchasable
FAS_HUMAN
HMDB Protein
HMDBP00035
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
13
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
11
UniProt:Q99IB8-PRO_0000045603
0.556
6
UniProt:Q15848 ADIPOQ
1
ADIPOQ [extracellular region]
(R-HSA-1183052)
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.547
2
UniProt:Q8IV20 LACC1
0.539
8
UniProt:Q8N8N7 PTGR2
1
PTGR2 [cytosol]
(R-HSA-8940670)
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.527
2
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.463
4
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