AKT phosphorylates CREB1

Stable Identifier
R-HSA-199298
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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AKT phosphorylates CREB1
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AKT phosphorylates CREB (cAMP response element-binding protein) at serine 133 and activates gene expression via a CREB-dependent mechanism, thus promoting cell survival.
Literature References
PubMed ID Title Journal Year
9829964 CREB is a regulatory target for the protein kinase Akt/PKB

Du, K, Montminy, M

J Biol Chem 1998
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
phosphatidylinositol 3-kinase/protein kinase B signal transduction (0043491)
Catalyst Activity

protein serine/threonine kinase activity of p-T,p-S-AKT [nucleoplasm]

Physical Entity
p-T,p-S-AKT [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AKT phosphorylates CREB1 (Caenorhabditis elegans)
AKT phosphorylates CREB1 (Danio rerio)
AKT phosphorylates CREB1 (Drosophila melanogaster)
AKT phosphorylates CREB1 (Gallus gallus)
AKT phosphorylates CREB1 (Mus musculus)
AKT phosphorylates CREB1 (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-07-10)
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