FOXO1 [nucleoplasm]

Stable Identifier
R-HSA-199300
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Forkhead box protein O1A, FOXO1_HUMAN, FOXO1A
Icon
FOXO1 [nucleoplasm] icon
FOXO1 [nucleoplasm] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q12778 FOXO1
Gene Names
FOXO1, FKHR, FOXO1A
Chain
chain:1-655
Reference Genes
BioGPS Gene:2308 FOXO1
COSMIC (genes):FOXO1 FOXO1
CTD Gene:2308 FOXO1
dbSNP Gene:2308 FOXO1
ENSEMBL:ENSG00000150907 FOXO1
ENSEMBL_homo_sapiens_GENE:ENSG00000150907.10 FOXO1
HGNC:3819 FOXO1
KEGG Gene (Homo sapiens):2308 FOXO1
Monarch:2308 FOXO1
NCBI Gene:2308 FOXO1
OMIM:136533 FOXO1
UCSC:Q12778 FOXO1
Reference Transcript
Other Identifiers
11727927_a_at
11727928_at
11727929_a_at
11755772_a_at
16778392
202723_PM_s_at
202723_s_at
202724_PM_s_at
202724_s_at
2308
3510859
3510861
3510904
3510905
3510906
3510907
3510908
3510909
40570_at
7971177
A_23_P151426
A_24_P22079
GE54250
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0001568
GO:0001659
GO:0001678
GO:0003012
GO:0003676
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006111
GO:0006351
GO:0006355
GO:0006357
GO:0006473
GO:0006914
GO:0006915
GO:0006974
GO:0008013
GO:0008286
GO:0009267
GO:0010467
GO:0010508
GO:0012501
GO:0023052
GO:0030154
GO:0030163
GO:0031490
GO:0031625
GO:0032868
GO:0032869
GO:0032873
GO:0034393
GO:0034599
GO:0036211
GO:0042127
GO:0042593
GO:0043065
GO:0043066
GO:0043226
GO:0043565
GO:0045444
GO:0045599
GO:0045722
GO:0045732
GO:0045892
GO:0045893
GO:0045944
GO:0046676
GO:0048856
GO:0051721
GO:0060070
GO:0060260
GO:0070417
GO:0070542
GO:0071455
GO:0071732
GO:0090090
GO:0097009
GO:0097150
GO:0140110
GO:1903243
GO:1990841
GO:2000177
GO:2000377
HMNXSV003026619
Hs.170133.0.A1_3p_s_at
ILMN_1738816
PH_hs_0010156
TC13001719.hg
U02310_at
U36922_at
g9257221_3p_a_at
Participates
as a component of
as an input of
as an output of
as a member of
as a candidate of
This entity regulates
Negatively
Positively
Other forms of this molecule
p-S218-FOXO1 [nucleoplasm]
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
p-T24,S256,S319-FOXO1 [nucleoplasm]
p-T24,S256,S319-FOXO1 [cytosol]
Inferred To
daf-16 [nucleoplasm] (Caenorhabditis elegans)
foxo [nucleoplasm] (Drosophila melanogaster)
Foxo1 [nucleoplasm] (Mus musculus)
Foxo1 [nucleoplasm] (Rattus norvegicus)
foxo1a [nucleoplasm] (Danio rerio)
FOXO1 [nucleoplasm] (Bos taurus)
FOXO1 [nucleoplasm] (Canis familiaris)
FOXO1 [nucleoplasm] (Gallus gallus)
FOXO1 [nucleoplasm] (Sus scrofa)
foxo1 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
OpenTargets
ZINC - Substances
GeneCards
HPA
ZINC target
Ensembl
PRO
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
PDB
Interactors (16)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P63104 YWHAZ  2 0.788 6
 UniProt:Q04917 YWHAH  1 0.745 6
 UniProt:P61981 YWHAG  1 0.745 6
 UniProt:Q96EB6 SIRT1  1 0.702 4
 UniProt:P27348 YWHAQ  1 0.671 5
 UniProt:P06493 CDK1  11 0.645 5
 UniProt:P31946 YWHAB  1 0.643 3
 UniProt:Q14192 FHL2  1 0.639 8
 UniProt:P62258 YWHAE  1 0.623 5
 UniProt:Q01105 SET  1 0.591 5
 UniProt:P14635 CCNB1  4 0.571 2
 UniProt:P31749 AKT1  14 0.571 2
 UniProt:Q92793 CREBBP  4 0.564 3
 UniProt:Q923E4 Sirt1  2 0.544 2
 UniProt:P14921-3 ETS1      0.544 2
 UniProt:P03372 ESR1  10 0.508 2
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