Reactome | FOXO3 [nucleoplasm]

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.851	6
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.774	6
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.774	6
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.743	9
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.706	5
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.704	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.695	5
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.692	3
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.667	5
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.632	7
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.615	3
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.591	4
IntAct:EBI-1767788 BIM			0.59	2
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.564	3
UniProt:Q60987 Foxg1	2	Foxg1 [nucleoplasm] (R-MMU-9022630) Foxg1 [nucleoplasm] (R-MMU-9022629)	0.544	5
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.536	2
IntAct:EBI-1657542 ERALPHA			0.527	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.524	3
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.499	2
UniProt:O75529 TAF5L	1	TAF5L [nucleoplasm] (R-HSA-212336)	0.499	2
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.499	2
UniProt:Q92974 ARHGEF2	1	ARHGEF2 [cytosol] (R-HSA-195101)	0.499	2
UniProt:P85037 FOXK1	1	FOXK1 [nucleoplasm] (R-HSA-5689673)	0.499	2
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.499	2
UniProt:P28749 RBL1	2	RBL1 [nucleoplasm] (R-HSA-389104) p-T369,S640,S964,S975-RBL1 [nucleoplasm] (R-HSA-1226085)	0.499	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.471	3
UniProt:P30153 PPP2R1A	2	PPP2R1A [cytosol] (R-HSA-165982) PPP2R1A [nucleoplasm] (R-HSA-165968)	0.462	2
IntAct:EBI-2891650 CDKN1B			0.462	2
IntAct:EBI-2678752 ANDR			0.462	2

UniProt:P63104 YWHAZ

2

0.851

6

UniProt:P31946 YWHAB

1

YWHAB [cytosol] (R-HSA-48888)

0.774

6

UniProt:Q04917 YWHAH

1

YWHAH [cytosol] (R-HSA-1445107)

0.774

6

UniProt:Q13485 SMAD4

20

0.743

9

UniProt:P61981 YWHAG

1

YWHAG [cytosol] (R-HSA-380312)

0.706

5

UniProt:Q96EB6 SIRT1

1

SIRT1 [nucleoplasm] (R-HSA-427531)

0.704

5

UniProt:P62258 YWHAE

1

YWHAE [cytosol] (R-HSA-194368)

0.695

5

UniProt:P31749 AKT1

14

0.692

3

UniProt:P84022 SMAD3

20

0.667

5

UniProt:P03372 ESR1

10

0.632

7

UniProt:P27348 YWHAQ

1

YWHAQ [cytosol] (R-HSA-1445116)

0.615

3

UniProt:Q92731 ESR2

5

0.591

4

IntAct:EBI-1767788 BIM

0.59

2

UniProt:Q92793 CREBBP

4

0.564

3

UniProt:Q60987 Foxg1

2

0.544

5

UniProt:P04637 TP53

20

0.536

2

IntAct:EBI-1657542 ERALPHA

0.527

2

UniProt:P01106 MYC

2

0.524

3

UniProt:P06400 RB1

20

0.499

2

UniProt:O75529 TAF5L

1

TAF5L [nucleoplasm] (R-HSA-212336)

0.499

2

UniProt:Q96T60 PNKP

1

PNKP [nucleoplasm] (R-HSA-5649651)

0.499

2

UniProt:Q92974 ARHGEF2

1

ARHGEF2 [cytosol] (R-HSA-195101)

0.499

2

UniProt:P85037 FOXK1

1

FOXK1 [nucleoplasm] (R-HSA-5689673)

0.499

2

UniProt:P30260 CDC27

2

0.499

2

UniProt:P28749 RBL1

2

0.499

3

UniProt:P31947 SFN

1

SFN [cytosol] (R-HSA-1445105)

0.471

3

UniProt:P30153 PPP2R1A

2

0.462

2

IntAct:EBI-2891650 CDKN1B

0.462

2

IntAct:EBI-2678752 ANDR

0.462

2