Reactome | p-T24,S256,S319-FOXO1 [nucleoplasm]

p-T24,S256,S319-FOXO1 [nucleoplasm]

Stable Identifier

R-HSA-199306

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Phospho-Forkhead box protein O1A (T24, S256, S319), FOXO1_HUMAN, FOXO1A

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q12778 FOXO1

Gene Names

FOXO1, FKHR, FOXO1A

Chain

chain:1-655

Reference Genes

BioGPS Gene:2308 FOXO1

COSMIC (genes):FOXO1 FOXO1

CTD Gene:2308 FOXO1

dbSNP Gene:2308 FOXO1

ENSEMBL:ENSG00000150907 FOXO1

ENSEMBL_homo_sapiens_GENE:ENSG00000150907.10 FOXO1

HGNC:3819 FOXO1

KEGG Gene (Homo sapiens):2308 FOXO1

Monarch:2308 FOXO1

NCBI Gene:2308 FOXO1

OMIM:136533 FOXO1

UCSC:Q12778 FOXO1

Reference Transcript

RefSeq:NM_002015.3 FOXO1

Other Identifiers

11727927_a_at

11727928_at

11727929_a_at

11755772_a_at

16778392

202723_PM_s_at

202723_s_at

202724_PM_s_at

202724_s_at

2308

3510859

3510861

3510904

3510905

3510906

3510907

3510908

3510909

40570_at

7971177

A_23_P151426

A_24_P22079

GE54250

GO:0000122

GO:0000785

GO:0000978

GO:0000981

GO:0001227

GO:0001228

GO:0001568

GO:0001659

GO:0001678

GO:0003012

GO:0003676

GO:0003677

GO:0003682

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005739

GO:0005829

GO:0005975

GO:0006111

GO:0006351

GO:0006355

GO:0006357

GO:0006473

GO:0006914

GO:0006915

GO:0006974

GO:0008013

GO:0008286

GO:0009267

GO:0010467

GO:0010508

GO:0012501

GO:0023052

GO:0030154

GO:0030163

GO:0031490

GO:0031625

GO:0032868

GO:0032869

GO:0032873

GO:0034393

GO:0034599

GO:0036211

GO:0042127

GO:0042593

GO:0043065

GO:0043066

GO:0043226

GO:0043565

GO:0045444

GO:0045599

GO:0045722

GO:0045732

GO:0045892

GO:0045893

GO:0045944

GO:0046676

GO:0048856

GO:0051721

GO:0060070

GO:0060260

GO:0070417

GO:0070542

GO:0071455

GO:0071732

GO:0090090

GO:0097009

GO:0097150

GO:0140110

GO:1903243

GO:1990841

GO:2000177

GO:2000377

HMNXSV003026619

Hs.170133.0.A1_3p_s_at

ILMN_1738816

PH_hs_0010156

TC13001719.hg

U02310_at

U36922_at

g9257221_3p_a_at

Participates

as an output of

AKT phosphorylates FOXO1A (Homo sapiens)

as an input of

Phosphorylated FOXO1A is excluded from the nucleus (Homo sapiens)

as a member of

Other forms of this molecule

p-S218-FOXO1 [nucleoplasm]

Ac-K245,K248,K265-FOXO1 [nucleoplasm]

FOXO1 [nucleoplasm]

p-T24,S256,S319-FOXO1 [cytosol]

Inferred To

phospho-p-T24,S256,S319-FOXO1 [nucleoplasm] (Gallus gallus)

phospho-FOXO1 [nucleoplasm] (Bos taurus)

phospho-FOXO1 [nucleoplasm] (Canis familiaris)

phospho-FOXO1 [nucleoplasm] (Sus scrofa)

phospho-foxo [nucleoplasm] (Drosophila melanogaster)

phospho-foxo1 [nucleoplasm] (Xenopus tropicalis)

phospho-foxo1a [nucleoplasm] (Danio rerio)

phospho-daf-16 [nucleoplasm] (Caenorhabditis elegans)

phospho-Foxo1 [nucleoplasm] (Mus musculus)

phospho-Foxo1 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-threonine at 24

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 256

Coordinate

256

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 319

Coordinate

319

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_002006.2

OpenTargets

ENSG00000150907

ZINC - Substances

FOXO1_HUMAN

GeneCards

Q12778

HPA

ENSG00000150907-FOXO1

ZINC target

Q12778

Ensembl

ENST00000379561, ENSG00000150907, ENSP00000368880

PRO

Q12778

Pharos - Targets

Q12778

ZINC - Predictions - Purchasable

FOXO1_HUMAN

Orphanet

16069

PDB

3CO7, 6QVW, 5DUI, 6QZR, 3COA, 6QZS, 8A65, 8A62, 4LG0, 3CO6, 6LBI

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.788	6
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.745	6
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.745	6
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.702	4
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.671	5
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.645	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.643	3
UniProt:Q14192 FHL2	1	FHL2 [nucleoplasm] (R-HSA-561161)	0.639	8
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.623	5
UniProt:Q01105 SET	1	SET [nucleoplasm] (R-HSA-451201)	0.591	5
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.571	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.571	2
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.564	3
UniProt:Q923E4 Sirt1	2	Sirt1 [nucleoplasm] (R-MMU-5211238) SIRT1 [nucleoplasm] (R-MMU-427531)	0.544	2
UniProt:P14921-3 ETS1			0.544	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.508	2

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