Negative regulation of the PI3K/AKT network

Stable Identifier
R-HSA-199418
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Negative regulation of the PI3K/AKT network
Click the image above or here to open this pathway in the Pathway Browser

The PI3K/AKT network is negatively regulated by phosphatases that dephosphorylate PIP3, thus hampering AKT activation.

Participants
Events
Participates
as an event of
Orthologous Events
Negative regulation of the PI3K/AKT network (Bos taurus)
Negative regulation of the PI3K/AKT network (Caenorhabditis elegans)
Negative regulation of the PI3K/AKT network (Canis familiaris)
Negative regulation of the PI3K/AKT network (Danio rerio)
Negative regulation of the PI3K/AKT network (Dictyostelium discoideum)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Gallus gallus)
Negative regulation of the PI3K/AKT network (Mus musculus)
Negative regulation of the PI3K/AKT network (Plasmodium falciparum)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Saccharomyces cerevisiae)
Negative regulation of the PI3K/AKT network (Schizosaccharomyces pombe)
Negative regulation of the PI3K/AKT network (Sus scrofa)
Negative regulation of the PI3K/AKT network (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Zhao, JJ  (2012-08-13)
Yuzugullu, H  (2012-08-13)
Thorpe, L  (2012-08-13)
Created
Jassal, B  (2007-07-10)
Cite Us!