Reactome | HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane]

Stable Identifier

R-HSA-199595

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

HLA-C, 1C07_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P10321 HLA-C

Gene Names

HLA-C, HLAC

Chain

signal peptide:1-24, chain:25-366

Reference Genes

BioGPS Gene:3107 HLA-C

COSMIC (genes):HLA-C HLA-C

CTD Gene:3107 HLA-C

dbSNP Gene:3107 HLA-C

ENSEMBL:ENSG00000204525 HLA-C

HGNC:4933 HLA-C

KEGG:hsa:3107 HLA-C

Monarch:3107 HLA-C

NCBI Gene:3107 HLA-C

UCSC:P10321 HLA-C

Reference Transcript

RefSeq:NM_002117.5 HLA-C

Other Identifiers

11715316_x_at

17017126

17029003

216526_PM_x_at

216526_x_at

2900985

2900990

2901160

2901186

2901190

2901216

2901249

2901470

2901471

2901631

2948892

2948893

2948894

2948896

2948897

2948898

2948899

2948900

2948901

2948902

2948903

2948904

2948905

2948906

2948907

2948908

2948909

2948910

2948911

2948912

2948913

2948914

2948915

2948916

2948917

2948918

2948919

2948945

2948946

2948951

3107

8124901

8178489

A_24_P298409

A_33_P3330109

GO:0000139

GO:0001916

GO:0002250

GO:0002376

GO:0002474

GO:0002476

GO:0002486

GO:0005102

GO:0005515

GO:0005615

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006955

GO:0009897

GO:0009986

GO:0012507

GO:0016020

GO:0019882

GO:0030667

GO:0030670

GO:0031901

GO:0042605

GO:0042612

GO:0043226

GO:0045087

GO:0046977

GO:0055038

GO:0070062

GO:0098542

GO:0098553

HMNXSV003005502

HMNXSV003026726

Hs.277477.2.S1_3p_x_at

ILMN_1721113

ILMN_2150787

TC06004059.hg

TC6_cox_hap2000236.hg

Participates

as a component of

as a member of

as a candidate of

LILR-binding HLA Class I [plasma membrane] (Homo sapiens)

Other forms of this molecule

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [phagocytic vesicle membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [recycling endosome membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [early endosome membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [ER to Golgi transport vesicle membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [Golgi membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [secretory granule membrane]

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [lumenal side of endoplasmic reticulum membrane]

Inferred To

DLA-79 [plasma membrane] (Canis familiaris)

H2-M1 [plasma membrane] (Mus musculus)

H2-Q7 [plasma membrane] (Mus musculus)

Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Bos taurus)

Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Canis familiaris)

Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Danio rerio)

Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Gallus gallus)

Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Mus musculus)

Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Rattus norvegicus)

Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Sus scrofa)

Homologues of HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Xenopus tropicalis)

mhc1-uba15 [plasma membrane] (Xenopus tropicalis)

RT1-M3-1 [plasma membrane] (Rattus norvegicus)

LOC100490728 [plasma membrane] (Xenopus tropicalis)

RT1-M1-4 [plasma membrane] (Rattus norvegicus)

H2-M10.3 [plasma membrane] (Mus musculus)

mhc1uma [plasma membrane] (Danio rerio)

H2-M10.4 [plasma membrane] (Mus musculus)

RT1-M1-5 [plasma membrane] (Rattus norvegicus)

H2-M10.6l [plasma membrane] (Rattus norvegicus)

H2-T23 [plasma membrane] (Mus musculus)

H2-K1 [plasma membrane] (Mus musculus)

RT1-N3 [plasma membrane] (Rattus norvegicus)

RT1-O1l1 [plasma membrane] (Rattus norvegicus)

mhc1laa [plasma membrane] (Danio rerio)

LOC119876868 [plasma membrane] (Canis familiaris)

H2-Q1 [plasma membrane] (Mus musculus)

mhc1zda [plasma membrane] (Danio rerio)

mhc1zea [plasma membrane] (Danio rerio)

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Bos taurus)

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Canis familiaris)

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Gallus gallus)

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Mus musculus)

HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [plasma membrane] (Sus scrofa)

mhc1zca [plasma membrane] (Danio rerio)

H2-M10.2 [plasma membrane] (Mus musculus)

H2-M5 [plasma membrane] (Mus musculus)

H2-Q6 [plasma membrane] (Mus musculus)

mhc1uba [plasma membrane] (Danio rerio)

mhc1zba [plasma membrane] (Danio rerio)

SLA-6 [plasma membrane] (Sus scrofa)

AABR07044362.1 [plasma membrane] (Rattus norvegicus)

mhc1zfa [plasma membrane] (Danio rerio)

BF1 [plasma membrane] (Gallus gallus)

RT1-M2 [plasma membrane] (Rattus norvegicus)

RT1-CE14 [plasma membrane] (Rattus norvegicus)

ENSRNOG00000064836 [plasma membrane] (Rattus norvegicus)

mhc1-uda [plasma membrane] (Xenopus tropicalis)

mhc1-uea [plasma membrane] (Xenopus tropicalis)

RT1-CE1 [plasma membrane] (Rattus norvegicus)

RT1-CE16 [plasma membrane] (Rattus norvegicus)

RT1-CE2 [plasma membrane] (Rattus norvegicus)

H2-M10.6 [plasma membrane] (Mus musculus)

SLA-7 [plasma membrane] (Sus scrofa)

RT1-CE10 [plasma membrane] (Rattus norvegicus)

AABR07044308.2 [plasma membrane] (Rattus norvegicus)

RT1-M1-2 [plasma membrane] (Rattus norvegicus)

SLA-2 [plasma membrane] (Sus scrofa)

H2-M10.1 [plasma membrane] (Mus musculus)

H2-Q10 [plasma membrane] (Mus musculus)

H2-M11 [plasma membrane] (Mus musculus)

H2-Q4 [plasma membrane] (Mus musculus)

mhc1-uba13.5 [plasma membrane] (Xenopus tropicalis)

RT1-S3 [plasma membrane] (Rattus norvegicus)

SLA-8 [plasma membrane] (Sus scrofa)

RT1-M10-1 [plasma membrane] (Rattus norvegicus)

SLA-3 [plasma membrane] (Sus scrofa)

ENSRNOG00000069480 [plasma membrane] (Rattus norvegicus)

H2-T3 [plasma membrane] (Mus musculus)

H2-M10.5 [plasma membrane] (Mus musculus)

RT1-M5 [plasma membrane] (Rattus norvegicus)

H2-D1 [plasma membrane] (Mus musculus)

DLA88 [plasma membrane] (Canis familiaris)

H2-M3 [plasma membrane] (Mus musculus)

BFIV21 [plasma membrane] (Gallus gallus)

H2-Q2 [plasma membrane] (Mus musculus)

H2-M9 [plasma membrane] (Mus musculus)

LOC100513601 [plasma membrane] (Sus scrofa)

DLA-12 [plasma membrane] (Canis familiaris)

H2-M2 [plasma membrane] (Mus musculus)

H2-T22 [plasma membrane] (Mus musculus)

mr1l [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002108.4

ENSEMBL

ENST00000376228, ENSP00000365402

OpenTargets

ENSG00000204525

HPA

ENSG00000204525-HLA-C

PRO

P10321

Pharos - Targets

P10321

GlyGen

P10321

PDB

6JTO, 5W6A, 3BZF, 4NT6, 5VGD, 5VGE, 1IM9, 1EFX, 6PAG, 5W67, 6PA1, 1QQD, 5W69

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.875	11
UniProt:P43626 KIR2DL1	1	KIR2DL1 [plasma membrane] (R-HSA-199538)	0.792	15
UniProt:Q9UI95 MAD2L2	1	MAD2L2 [nucleoplasm] (R-HSA-59092)	0.643	3
UniProt:Q63HN8 RNF213	3	RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9715284) RNF213(1-1172)-ALK(1058-1620) fusion [cytosol] (R-HSA-9715291) RNF213 [cytosol] (R-HSA-9635613)	0.564	2
UniProt:P01222 TSHB	1	TSHB [extracellular region] (R-HSA-378957)	0.527	2
UniProt:Q01974 ROR2	2	ROR2 [plasma membrane] (R-HSA-197731) ROR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140729)	0.527	2
UniProt:A0PJW6 TMEM223	1	TMEM223 [mitochondrial inner membrane] (R-HSA-9865797)	0.527	2

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