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p-T154,S315-NCF4 [phagolysosome]
Stable Identifier
R-HSA-1996221
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
phagolysosome
Synonyms
p-T154,S315-p40phox, Neutrophil cytosol factor 4, NCF4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing-Cross presentation (Homo sapiens)
Cross-presentation of particulate exogenous antigens (phagosomes) (Homo sapiens)
Alkalization of the phagosomal lumen by NOX2 (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
p-T154,S315-NCF4 [phagolysosome] (Homo sapiens)
Innate Immune System (Homo sapiens)
ROS and RNS production in phagocytes (Homo sapiens)
NOX2 generates superoxide anion from oxygen (Homo sapiens)
NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
p-T154,S315-NCF4 [phagolysosome] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP (Homo sapiens)
NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
p-T154,S315-NCF4 [phagolysosome] (Homo sapiens)
NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
p-T154,S315-NCF4 [phagolysosome] (Homo sapiens)
RAC2:GTP binds NOX2 complex (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
p-T154,S315-NCF4 [phagolysosome] (Homo sapiens)
NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
p-T154,S315-NCF4 [phagolysosome] (Homo sapiens)
S100A8:S100A9:AA:Ca(2+) binds NOX2 complex (Homo sapiens)
NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
p-T154,S315-NCF4 [phagolysosome] (Homo sapiens)
NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
p-T154,S315-NCF4 [phagolysosome] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 binds effectors at the phagocytic vesicle membrane (Homo sapiens)
RAC2 phagosome effectors [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
p-T154,S315-NCF4 [phagolysosome] (Homo sapiens)
RAC2:GTP:RAC2 phagosome effectors [phagocytic vesicle membrane] (Homo sapiens)
RAC2 phagosome effectors [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
p-T154,S315-NCF4 [phagolysosome] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
9804763
p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process
Fuchs, A
,
Bouin, AP
,
Vignais, PV
,
Grandvaux, N
J. Biol. Chem.
1998
External Reference Information
External Reference
UniProt:Q15080 NCF4
Gene Names
NCF4, SH3PXD4
Chain
chain:1-339
Reference Genes
BioGPS Gene:4689 NCF4
COSMIC (genes):NCF4 NCF4
CTD Gene:4689 NCF4
dbSNP Gene:4689 NCF4
ENSEMBL:ENSG00000100365 NCF4
ENSEMBL_homo_sapiens_GENE:ENSG00000100365.16 NCF4
HGNC:7662 NCF4
KEGG Gene (Homo sapiens):4689 NCF4
Monarch:4689 NCF4
NCBI Gene:4689 NCF4
OMIM:601488 NCF4
UCSC:Q15080 NCF4
Reference Transcript
RefSeq:NM_000631.4 NCF4
RefSeq:NM_013416.3 NCF4
Other Identifiers
11723106_a_at
16929662
205147_PM_x_at
205147_x_at
207677_PM_s_at
207677_s_at
38893_at
38894_g_at
38895_i_at
3944544
3944545
3944547
3944548
3944549
3944551
3944552
3944554
3944555
3944556
3944557
3944558
3944559
3944560
3944561
4689
8072744
A_23_P109508
A_33_P3365432
GE62052
GO:0005515
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0006909
GO:0008289
GO:0010008
GO:0016020
GO:0016176
GO:0016192
GO:0031410
GO:0032010
GO:0032266
GO:0035091
GO:0042554
GO:0043020
GO:0043226
GO:0045730
GO:0098772
HMNXSV003054798
ILMN_1757361
ILMN_1785005
ILMN_2335704
TC22000270.hg
X77094_at
g7382492_3p_a_at
Participates
as a component of
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
NCF4 [cytosol]
Inferred To
phospho-Ncf4 [phagolysosome]
(Rattus norvegicus)
Ghost homologue of p-T154,S315-NCF4 [phagolysosome]
(Danio rerio)
phospho-ncf4 [phagolysosome]
(Xenopus tropicalis)
phospho-NCF4 [phagolysosome]
(Bos taurus)
phospho-NCF4 [phagolysosome]
(Canis familiaris)
phospho-NCF4 [phagolysosome]
(Gallus gallus)
phospho-NCF4 [phagolysosome]
(Sus scrofa)
phospho-p-T154,S315-NCF4 [phagolysosome]
(Mus musculus)
Modified Residues
Name
O-phospho-L-threonine at 154
Coordinate
154
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 315
Coordinate
315
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_038202.2
,
NP_000622.2
OpenTargets
ENSG00000100365
GeneCards
Q15080
HPA
ENSG00000100365-NCF4
Ensembl
ENSP00000248899
,
ENST00000397147
,
ENSP00000380334
,
ENSG00000100365
,
ENST00000248899
PRO
Q15080
Pharos - Targets
Q15080
Orphanet
18486
HMDB Protein
HMDBP01615
PDB
1W6X
,
1Z9Q
,
2DYB
,
1OEY
,
1W70
,
1H6H
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