EGFR A289T [plasma membrane]

Stable Identifier
R-HSA-1996306
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Epidermal Growth Factor Receptor A289T, EGFR Ala289Thr
EGFR A289T [plasma membrane] icon
Locations in the PathwayBrowser
External Reference Information
External Reference
Gene Names
EGFR, ERBB, ERBB1, HER1
Chain
signal peptide:1-24, chain:25-1210
Participates
Other forms of this molecule
Modified Residues
Name
L-alanine 289 replaced with L-threonine
Coordinate
289
PsiMod
A protein modification that effectively removes or replaces an L-alanine.
A protein modification that effectively converts a source amino acid residue to L-threonine.
Disease
Name Identifier Synonyms
brain oligodendroglioma DOID:3187 Oligodendroglioma of brain (disorder), brain Oligodendroglioma
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
brain glioma DOID:0060108
glioblastoma multiforme DOID:3068 GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
astrocytoma DOID:3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
Cross References
COSMIC
Interactors (324)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P62993 GRB2  1 0.983 59
 UniProt:P00533 EGFR  20 0.981 29
 UniProt:P29353 SHC1  5 0.976 44
 UniProt:P01133 EGF  5 0.973 29
 UniProt:P22681 CBL  20 0.964 26
 UniProt:P04626 ERBB2  20 0.954 25
 UniProt:P21860 ERBB3      0.919 14
 UniProt:P40763 STAT3  12 0.919 15
 UniProt:P12931 SRC  6 0.9 9
 UniProt:Q9UJM3 ERRFI      0.9 15
 UniProt:P18031 PTPN1  2 0.898 9
 UniProt:P08238 HSP90AB1  6 0.89 10
 UniProt:P27348 YWHAQ  1 0.854 7
 UniProt:P19174 PLCG1  6 0.85 6
 UniProt:P31947 SFN  1 0.833 9
 UniProt:P62158 CALM      0.828 6
 UniProt:Q96CW1 AP2M1  6 0.828 8
 UniProt:P16333 NCK1  2 0.823 6
 UniProt:Q06124 PTPN11  4 0.821 8
 UniProt:P07948 LYN  7 0.82 7
 UniProt:P15941 MUC1  19 0.819 6
 UniProt:Q03135 CAV1  5 0.813 7
 UniProt:O00750 PIK3C2B  1 0.811 10
 UniProt:P27986 PIK3R1  16 0.81 7
 UniProt:Q9UBN7 HDAC6  4 0.809 12
 UniProt:Q05209 PTPN12  2 0.807 5
 UniProt:P11142 HSPA8  10 0.803 7
 UniProt:P20417  2 0.802 11
 UniProt:P08581 MET  7 0.8 8
 UniProt:P08107 HSP71      0.799 6
 UniProt:Q92625 ANS1A      0.793 7
 UniProt:P16885 PLCG2  8 0.793 6
 UniProt:Q16543 CDC37  1 0.786 13
 UniProt:P04406 GAPDH  1 0.785 7
 UniProt:P10599 TXN  4 0.785 5
 UniProt:P01135 TGFA  5 0.779 4
 UniProt:P07900 HSP90AA1  8 0.778 7
 UniProt:P42224 STAT1  8 0.774 7
 UniProt:Q9NRF2 SH2B1  1 0.773 4
 UniProt:P63104 YWHAZ  2 0.772 6
 UniProt:P04083 ANXA1  2 0.772 5
 UniProt:Q92569 PIK3R3  2 0.76 7
 UniProt:O00459 PIK3R2  3 0.76 5
 UniProt:P46109 CRKL  2 0.749 5
 UniProt:Q71U36 TUBA1A  9 0.745 4
 UniProt:O60716 CTNND1  1 0.745 5
 UniProt:Q05397 PTK2  11 0.745 7
 UniProt:P38646 HSPA9  6 0.745 5
 UniProt:Q96JA1 LRIG1  2 0.743 6
 UniProt:P26447 S10A4      0.743 6
 UniProt:Q92870 APBB2      0.737 7
 UniProt:Q9NSE2 CISH  1 0.737 4
 UniProt:P12830 CDH1  8 0.735 4
 UniProt:Q13480 GAB1  4 0.735 5
 UniProt:Q9UQB8 BAIAP2  1 0.735 4
 UniProt:Q13322 GRB10  2 0.729 4
 UniProt:Q9UNE7 STUB1  1 0.721 4
 UniProt:Q12929 EPS8  1 0.713 4
 UniProt:Q9P0L0 VAPA  4 0.713 4
 UniProt:Q96B97 SH3KBP1  3 0.695 4
 UniProt:Q13387 JIP2      0.692 5
 UniProt:P46108 CRK  1 0.692 4
 UniProt:P23467 PTPRB  3 0.692 3
 UniProt:P43403 ZAP70  3 0.692 3
 UniProt:P00519 ABL1  6 0.692 3
 UniProt:P51451 BLK  2 0.692 3
 UniProt:Q13239 SLA  1 0.692 3
 UniProt:P42684 ABL2  1 0.692 9
 UniProt:Q8TF42 UBS3B      0.69 7
 UniProt:Q14318 FKBP8  2 0.683 4
 UniProt:Q68CZ2 TNS3  1 0.683 5
 UniProt:P16234 PDGFRA  20 0.683 4
 UniProt:Q99962 SH3GL2  4 0.681 4
 UniProt:O75368 SH3L1      0.681 3
 UniProt:Q8WUM4 PDCD6IP  1 0.681 4
 UniProt:P41240 CSK  2 0.681 3
 UniProt:O60603 TLR2  3 0.681 3
 UniProt:P35221 CTNNA1  2 0.68 5
 UniProt:Q9UKV8 AGO2  2 0.679 11
 UniProt:O95782 AP2A1  5 0.671 6
 UniProt:Q9UQC2 GAB2  5 0.669 3
 UniProt:Q07889 SOS1  3 0.669 3
 UniProt:P34932 HSPA4  2 0.668 3
 UniProt:P23528 CFL1  3 0.668 3
 UniProt:Q09666 AHNK      0.667 4
 UniProt:P51636 CAV2  2 0.667 3
 UniProt:P06493 CDK1  11 0.667 3
 UniProt:Q9NZM3 ITSN2  1 0.653 3
 UniProt:Q15750 TAB1  6 0.653 3
 UniProt:P14923 JUP  6 0.653 3
 UniProt:P15311 EZR  3 0.653 3
 UniProt:P08631 HCK  2 0.653 3
 UniProt:Q10567 AP1B1  5 0.649 4
 UniProt:Q8NBJ4 GOLM1  2 0.644 13
 UniProt:P08195 SLC3A2  1 0.643 5
 UniProt:P16615 ATP2A2  2 0.643 3
 UniProt:P60520 GABARAPL2  3 0.635 3
 UniProt:P04150 NR3C1  3 0.635 3
 UniProt:P18433 PTPRA  1 0.635 3
 UniProt:Q9Y2H9 MAST1      0.635 3
 UniProt:P42229 STAT5A  4 0.635 4
 UniProt:P17252 PRKCA  8 0.635 3
 UniProt:P49069 CAMLG  1 0.635 3
 UniProt:Q6S5L8 SHC4      0.635 3
 UniProt:Q9Y2R2 PTPN22  1 0.635 3
 UniProt:Q8WUI4 HDAC7  1 0.635 3
 UniProt:Q02952 AKAP12  1 0.635 3
 UniProt:Q9BRG2 SH23A      0.635 3
 UniProt:P09936 UCHL1  1 0.635 3
 UniProt:P31948 STIP1  1 0.635 3
 UniProt:O43561 LAT  3 0.635 3
 UniProt:Q14247 CTTN  2 0.635 4
 UniProt:Q13094 LCP2  2 0.635 3
 UniProt:P09769 FGR  3 0.635 3
 UniProt:O75791 GRAP2  1 0.635 3
 UniProt:Q12933 TRAF2  5 0.635 4
 UniProt:Q14457 BECN1  4 0.628 7
 UniProt:P46940 IQGAP1  3 0.626 4
 UniProt:Q13438 OS9  1 0.623 3
 UniProt:Q12852 M3K12      0.621 3
 UniProt:Q6UW88 EPGN  2 0.618 3
 UniProt:O14944 EREG  2 0.618 3
 UniProt:P04792 HSBP1  3 0.615 3
 UniProt:Q99075 HBEGF  8 0.609 3
 UniProt:Q9UJ41 RABGEF1  2 0.599 4
 UniProt:Q86VI4 LAP4B      0.599 10
 UniProt:P60033 CD81  1 0.597 6
 UniProt:P08575 PTPRC  2 0.592 2
 UniProt:P14174 MIF  3 0.591 3
 UniProt:Q8IZW8 TNS4  1 0.59 2
 UniProt:P07355 ANXA2  6 0.583 4
 UniProt:O75886 STAM2  2 0.583 3
 UniProt:P29353-7 SHC1      0.581 4
 UniProt:O14965 AURKA  6 0.581 4
 UniProt:Q01973 ROR1  2 0.576 8
 UniProt:P23470 PTPRG      0.573 3
 UniProt:Q9UKG1 APPL1  1 0.571 3
 UniProt:Q9Y6R0 NUMBL      0.571 2
 UniProt:P49757 NUMB  1 0.571 2
 UniProt:P07992 ERCC1  2 0.571 21
 UniProt:P63010 AP2B1  4 0.569 5
 UniProt:P53680 AP2S1  4 0.569 3
 UniProt:O94973 AP2A2  6 0.569 4
 UniProt:hspa1a_hspa1b_human-1 EBI-11820565      0.569 3
 UniProt:Q9UBS4 DNAJB11  1 0.569 3
 UniProt:Q92622 RUBIC      0.564 3
 UniProt:Q15303 ERBB4      0.564 3
 UniProt:P07947 YES1  2 0.564 3
 UniProt:Q13451 FKBP5  2 0.564 2
 UniProt:P62994 Grb2  3 0.564 5
 UniProt:Q8IZV2 CKLF8      0.556 3
 UniProt:O75674 TM1L1      0.556 6
 UniProt:Q05513 PRKCZ  5 0.553 2
 UniProt:P05107 ITGB2  4 0.553 2
 UniProt:P40925 MDH1  1 0.553 2
 UniProt:Q99608 NDN  1 0.553 2
 UniProt:Q9H299 SH3L3      0.553 2
 UniProt:Q8N111 CEND      0.553 2
 UniProt:Q59GR8 Q59GR8      0.553 2
 UniProt:Q14204 DYNC1H1  3 0.553 2
 UniProt:P16930 FAH  1 0.553 2
 UniProt:Q59G22 Q59G22      0.553 2
 UniProt:Q13491 GPM6B      0.553 2
 UniProt:A4FU49 SH321      0.553 2
 UniProt:P60174 TPI1  1 0.553 2
 UniProt:O95433 AHSA1      0.553 2
 UniProt:Q7L273 KCTD9      0.553 2
 UniProt:Q4KWH8 PLCH1  1 0.553 2
 UniProt:O15511 ARPC5  4 0.553 2
 UniProt:Q99759 MAP3K3  1 0.553 2
 UniProt:P31321 PRKAR1B  2 0.553 2
 UniProt:P19438 TNFRSF1A  2 0.553 2
 UniProt:Q16186 ADRM1  2 0.553 2
 UniProt:P06132 UROD  1 0.553 2
 UniProt:P04075 ALDOA  6 0.553 2
 UniProt:P41222 PTGDS  1 0.553 2
 UniProt:Q8TDI0 CHD5      0.553 2
 UniProt:Q02790 FKBP4  3 0.553 2
 UniProt:P06396 GSN  7 0.553 2
 UniProt:Q8N2Y8 RUSC2      0.553 2
 UniProt:P05067 APP  20 0.553 2
 UniProt:Q13561 DCTN2  1 0.553 2
 UniProt:Q53GZ6 Q53GZ6      0.553 2
 UniProt:P17600 SYN1  2 0.553 2
 UniProt:P31939 ATIC  5 0.553 2
 UniProt:Q08881 ITK  3 0.553 2
 UniProt:P54368 OAZ1  1 0.553 2
 UniProt:Q9UPY6 WASF3  3 0.553 2
 UniProt:P17174 GOT1  1 0.553 2
 UniProt:Q9NNZ3 DNJC4      0.553 2
 UniProt:Q9Y5X1 SNX9  3 0.553 2
 UniProt:Q14050 COL9A3  20 0.553 2
 UniProt:O94992 HEXI1      0.553 2
 UniProt:O43639 NCK2  1 0.553 2
 UniProt:Q9Y3A3 PHOCN      0.553 2
 UniProt:Q96AD5 PNPLA2  4 0.553 2
 UniProt:O94875 SRBS2      0.553 2
 UniProt:P07949 RET  2 0.553 2
 UniProt:Q15819 UBE2V2  2 0.553 2
 UniProt:P45984 MAPK9  3 0.553 2
 UniProt:Q6UWJ1 TMCO3      0.553 2
 UniProt:Q99784 NOE1      0.553 2
 UniProt:Q92918 M4K1      0.553 2
 UniProt:Q07890 SOS2  1 0.553 2
 UniProt:P49798 RGS4  1 0.553 2
 UniProt:O75095 MEGF6      0.553 2
 UniProt:Q15120 PDK3  1 0.553 2
 UniProt:O43707 ACTN4  3 0.553 2
 UniProt:Q8N5H7 SH2D3      0.553 2
 UniProt:Q02297 NRG1  1 0.553 2
 UniProt:P62330 ARF6  2 0.553 2
 UniProt:P52306 RAP1GDS1  1 0.553 2
 UniProt:Q15005 SPCS2  1 0.553 2
 UniProt:Q92733 PRCC  1 0.553 2
 UniProt:Q9Y6K9 IKBKG  12 0.553 2
 UniProt:Q59EJ3 Q59EJ3      0.553 2
 UniProt:P43243 MATR3      0.553 2
 UniProt:P53041 PPP5C  2 0.553 2
 UniProt:P49908 SELENOP  2 0.553 2
 UniProt:Q8TDB4 HUMMR      0.553 2
 UniProt:Q02156 PRKCE  2 0.553 2
 UniProt:Q9Y237 PIN4      0.553 2
 UniProt:Q07954 LRP1  2 0.553 2
 UniProt:Q14155 ARHGEF7  1 0.553 2
 UniProt:P42685 FRK  4 0.553 2
 UniProt:P20336 RAB3A  9 0.553 2
 UniProt:P52630 STAT2  4 0.553 2
 UniProt:P60880 SNAP25  7 0.553 2
 UniProt:P15498 VAV1  5 0.553 2
 UniProt:P21291 CSRP1  1 0.553 2
 UniProt:Q13153 PAK1  5 0.553 2
 UniProt:O14818 PSMA7  2 0.553 2
 UniProt:Q13905 RAPGEF1  2 0.553 2
 UniProt:Q99952 PTPN18  2 0.553 2
 UniProt:Q99704 DOK1  2 0.553 2
 UniProt:P55036 PSMD4  1 0.553 2
 UniProt:P30307 CDC25C  8 0.553 2
 UniProt:Q02246 CNTN2  1 0.553 2
 UniProt:O14543 SOCS3  1 0.553 2
 UniProt:P26641 EEF1G  3 0.553 2
 UniProt:Q9UGK3 STAP2  2 0.553 2
 UniProt:P10636 MAPT  3 0.553 2
 UniProt:P37840 SNCA  5 0.553 2
 UniProt:Q9H6Q3 SLA2  1 0.553 2
 UniProt:Q99963 SH3GL3  1 0.553 2
 UniProt:P49407 ARRB1  6 0.553 2
 UniProt:O14544 SOCS6  1 0.553 2
 UniProt:Q06830 PRDX1  3 0.553 2
 UniProt:P32121 ARRB2  3 0.553 2
 UniProt:Q16620 NTRK2  6 0.553 2
 UniProt:P31946 YWHAB  1 0.553 2
 UniProt:O00170 AIP  2 0.553 2
 UniProt:P11309 PIM1  1 0.553 2
 UniProt:O00401 WASL  4 0.553 2
 UniProt:P31749 AKT1  14 0.553 2
 UniProt:P04049 RAF1  20 0.553 2
 UniProt:P16152 CBR1  1 0.553 2
 UniProt:P14625 HSP90B1  4 0.553 2
 UniProt:P45983 MAPK8  3 0.553 2
 UniProt:P10586 PTPRF  2 0.547 2
 UniProt:P29350 PTPN6  5 0.547 2
 UniProt:P23468 PTPRD  1 0.547 2
 UniProt:Q14956-1 GPNMB      0.544 2
 UniProt:P07948-1 LYN      0.544 2
 UniProt:Q38SD2 LRRK1      0.544 2
 UniProt:P17936 IGFBP3  15 0.539 3
 UniProt:P0DTC2 S  20 0.537 4
 UniProt:O14964 HGS  2 0.536 2
 UniProt:P68366 TUBA4A  9 0.527 2
 UniProt:P55060 XPO2      0.527 2
 UniProt:Q6XE38 SG1D4      0.527 2
 UniProt:P40855 PEX19  1 0.527 2
 UniProt:Q00325 S25A3      0.527 3
 UniProt:O60884 DNAJA2  1 0.527 2
 UniProt:O00483 NDUFA4  1 0.527 2
 UniProt:P31943 HNRNPH1  1 0.527 2
 UniProt:P11021 HSPA5  6 0.527 5
 UniProt:O43592 XPOT  2 0.527 2
 UniProt:Q9H0D6 XRN2  2 0.527 5
 UniProt:Q9Y4L1 HYOU1  3 0.527 2
 UniProt:P62161 CALM      0.524 6
 UniProt:P03372-4 ESR1  4 0.524 4
 UniProt:Q14956 GPNMB