Reactome Pathway Database

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      • p-6Y-EGFR T263P [plasma membrane]

      Stable Identifier
      R-HSA-1996336
      Type
      Protein [EntityWithAccessionedSequence]
      Species
      Homo sapiens
      Compartment
      plasma membrane
      Synonyms
      Phosphorylated Epidermal Growth Factor ReceptorT263P, p-6Y-EGFR Thr263Pro
      Icon
      p-6Y-EGFR T263P [plasma membrane] icon
      p-6Y-EGFR T263P [plasma membrane] icon
      Locations in the PathwayBrowser
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      Disease (Homo sapiens)
        • Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
          • Signaling by EGFR in Cancer (Homo sapiens)
            • Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
              • Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
                • Binding of CBL to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                    • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                    • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                    • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                    • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                    • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                    • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Binding of PI3K to complex of GRB2:GAB1 and ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                        • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                              • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                                • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                        • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                              • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                                • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Binding of SHC1 to p-6Y-EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                    • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                    • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Conversion of PIP2 to PIP3 by PI3K bound to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutants:GRB2:GAB1 [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                        • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                              • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                                • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                        • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                              • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                                • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Dissociation of phosphorylated PLCG1 from ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                    • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                    • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • PLCG1 binds to ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                    • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                    • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Phosphorylated SHC1 in complex with ligand-responsive p-6Y-EGFR mutants recruits GRB2:SOS1 complex (Homo sapiens)
                  • Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                        • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                              • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                                • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                        • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                              • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                                • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:CBL [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:p-Y371-CBL [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:PLCG1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:SHC1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutants:GRB2:SOS1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                      • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                      • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                              • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants) (Homo sapiens)
                  • Ligand responsive p-6Y-EGFR mutants:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
                    • Ligand-responsive p-6Y-EGFR mutants:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                        • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                          • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                              • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                                • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                        • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                            • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                              • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                                • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                • Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers (Homo sapiens)
                  • Ligand-responsive p-6Y-EGFR mutant dimers [plasma membrane] (Homo sapiens)
                    • Dimers of EGF:Ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • EGF:Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • EGF:Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
                    • Dimers of ligand-responsive p-6Y-EGFR mutants [plasma membrane] (Homo sapiens)
                      • Ligand-responsive p-6Y-EGFR mutants:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                        • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs:HSP90:CDC37 [plasma membrane] (Homo sapiens)
                          • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
                            • p-6Y-EGFR T263P [plasma membrane] (Homo sapiens)
      External Reference Information
      External Reference
      UniProt:P00533 EGFR
      Gene Names
      EGFR, ERBB, ERBB1, HER1
      Chain
      signal peptide:1-24, chain:25-1210
      Reference Genes
      COSMIC (genes):EGFR EGFR
      dbSNP Gene:1956 EGFR
      ENSEMBL:ENSG00000146648 EGFR
      Participates
      as a candidate of
      • Ligand-responsive p-6Y-EGFR mutants sensitive to non-covalent TKIs [plasma membrane] (Homo sapiens)
      Other forms of this molecule
      p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
      p-5Y-EGFRvIII [plasma membrane]
      EGFRvIII [plasma membrane]
      p-6Y-EGFR E746_A750del;T790M [plasma membrane]
      p-6Y-EGFR L858R;T790M [plasma membrane]
      p-6Y-EGFR A767_V769dup [plasma membrane]
      p-6Y-EGFR N771_H773dup [plasma membrane]
      p-6Y-EGFR K739_I744dup [plasma membrane]
      p-6Y-EGFR D770_N771insNPG [plasma membrane]
      p-6Y-EGFR E746_A750del [plasma membrane]
      p-6Y-EGFR L858R [plasma membrane]
      p-6Y-EGFR G719S [plasma membrane]
      p-6Y-EGFR L747_P753delinsS [plasma membrane]
      p-6Y-EGFR L747_A750delinsP [plasma membrane]
      p-6Y-EGFR L747_T751del [plasma membrane]
      p-6Y-EGFR L747_S752del [plasma membrane]
      p-6Y-EGFR L747_T751delinsP [plasma membrane]
      p-6Y-EGFR E746_T751delinsA [plasma membrane]
      p-6Y-EGFR E746_S752delinsV [plasma membrane]
      p-6Y-EGFR L861Q [plasma membrane]
      p-6Y-EGFR A289V [plasma membrane]
      p-6Y-EGFR G598V [plasma membrane]
      p-6Y-EGFR R108K [plasma membrane]
      p-6Y-EGFR A289T [plasma membrane]
      p-6Y-EGFR G719C [plasma membrane]
      p-6Y-EGFR A289D [plasma membrane]
      p-6Y-EGFR G719A [plasma membrane]
      EGFR L858R;T790M [plasma membrane]
      EGFR E746_A750del;T790M [plasma membrane]
      EGFR D770_N771insNPG [plasma membrane]
      EGFR K739_I744dup [plasma membrane]
      EGFR A767_V769dup [plasma membrane]
      EGFR N771_H773dup [plasma membrane]
      EGFR L858R [plasma membrane]
      EGFR G719S [plasma membrane]
      EGFR E746_A750del [plasma membrane]
      p-6Y-EGFR [plasma membrane]
      p-Y1086,Y1101-EGFR [plasma membrane]
      EGFR [plasma membrane]
      p-Y1016,Y1069,Y1092,Y1110,Y1197-EGFR [plasma membrane]
      EGFR [endosome membrane]
      p-4Y-EGFR [plasma membrane]
      EGFR L747_S752del [plasma membrane]
      EGFR G598V [plasma membrane]
      EGFR T263P [plasma membrane]
      EGFR G719C [plasma membrane]
      EGFR E746_S752delinsV [plasma membrane]
      EGFR A289T [plasma membrane]
      EGFR G719A [plasma membrane]
      EGFR E746_T751delinsA [plasma membrane]
      EGFR L747_A750delinsP [plasma membrane]
      EGFR R108K [plasma membrane]
      EGFR L861Q [plasma membrane]
      EGFR A289D [plasma membrane]
      EGFR L747_T751del [plasma membrane]
      EGFR L747_T751delinsP [plasma membrane]
      EGFR A289V [plasma membrane]
      EGFR L747_P753delinsS [plasma membrane]
      Modified Residues
      Name
      L-threonine 263 replaced with L-proline
      Coordinate
      263
      PsiMod
      L-threonine removal [MOD:01647]
      A protein modification that effectively removes or replaces an L-threonine.
      L-proline residue [MOD:00024]
      A protein modification that effectively converts a source amino acid residue to L-proline.
      Name
      O4'-phospho-L-tyrosine at 1016
      Coordinate
      1016
      PsiMod Name
      O4'-phospho-L-tyrosine [MOD:00048]
      PsiMod Definition
      A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
      Name
      O4'-phospho-L-tyrosine at 1069
      Coordinate
      1069
      PsiMod Name
      O4'-phospho-L-tyrosine [MOD:00048]
      PsiMod Definition
      A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
      Name
      O4'-phospho-L-tyrosine at 1092
      Coordinate
      1092
      PsiMod Name
      O4'-phospho-L-tyrosine [MOD:00048]
      PsiMod Definition
      A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
      Name
      O4'-phospho-L-tyrosine at 1110
      Coordinate
      1110
      PsiMod Name
      O4'-phospho-L-tyrosine [MOD:00048]
      PsiMod Definition
      A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
      Name
      O4'-phospho-L-tyrosine at 1172
      Coordinate
      1172
      PsiMod Name
      O4'-phospho-L-tyrosine [MOD:00048]
      PsiMod Definition
      A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
      Name
      O4'-phospho-L-tyrosine at 1197
      Coordinate
      1197
      PsiMod Name
      O4'-phospho-L-tyrosine [MOD:00048]
      PsiMod Definition
      A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
      Disease
      Name Identifier Synonyms
      cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
      brain glioma DOID:0060108
      glioblastoma multiforme DOID:3068 GBM, adult glioblastoma multiforme, grade IV adult Astrocytic tumor, primary glioblastoma multiforme, spongioblastoma multiforme
      astrocytoma DOID:3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
      Cross References
      COSMIC
      COSV51768130
      Interactors (324)
      Accession #Entities Entities Confidence Score Evidence (IntAct)
       UniProt:P62993 GRB2  1
      • GRB2 [cytosol] (R-HSA-8983328)
      		0.983 59
       UniProt:P00533 EGFR  20
      • p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138)
      • p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649)
      • EGFRvIII [plasma membrane] (R-HSA-1214162)
      • p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985)
      • p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984)
      • p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343)
      • p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342)
      • p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346)
      • p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335)
      • p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214)
      • p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211)
      • p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417)
      • p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038)
      • p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044)
      • p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041)
      • p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040)
      • p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042)
      • p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037)
      • p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039)
      • p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)
      		0.981 29
       UniProt:P29353 SHC1  5
      • p-Y-SHC1 [cytosol] (R-HSA-162568)
      • SHC1 [cytosol] (R-HSA-74680)
      • p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)
      • p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276)
      • p-Y427-SHC1 [cytosol] (R-HSA-74684)
      		0.976 44
       UniProt:P01133 EGF  5
      • EGF [extracellular region] (R-HSA-179863)
      • Pro-EGF [plasma membrane] (R-HSA-179888)
      • Pro-EGF [platelet alpha granule lumen] (R-HSA-139875)
      • Pro-EGF [extracellular region] (R-HSA-54209)
      • EGF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869086)
      		0.973 29
       UniProt:P22681 CBL  20
      • PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893)
      • CBL R420G [cytosol] (R-HSA-9706203)
      • CBL R420Q [cytosol] (R-HSA-9706186)
      • CBL Y371H [cytosol] (R-HSA-9706680)
      • CBL H398Y [cytosol] (R-HSA-9706639)
      • CBL P417A [cytosol] (R-HSA-9706636)
      • CBL S376F [cytosol] (R-HSA-9706643)
      • CBL E366_Q409del [cytosol] (R-HSA-9706179)
      • CBL del366-477 [cytosol] (R-HSA-9706176)
      • CBL R499L [cytosol] (R-HSA-9706678)
      • CBL L380P [cytosol] (R-HSA-9706630)
      • CBL L287R [cytosol] (R-HSA-9706693)
      • CBL L380R [cytosol] (R-HSA-9706635)
      • CBL G375P [cytosol] (R-HSA-9706219)
      • CBL P417L [cytosol] (R-HSA-9706634)
      • CBL H398Q [cytosol] (R-HSA-9706633)
      • CBL P417R [cytosol] (R-HSA-9706632)
      • CBL [cytosol] (R-HSA-112199)
      • p-Y371-CBL [cytosol] (R-HSA-182940)
      • p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)
      		0.964 26
       UniProt:P04626 ERBB2  20
      • ERBB2 G309E [plasma membrane] (R-HSA-9665342)
      • ERBB2 G309A [plasma membrane] (R-HSA-9665349)
      • ERBB2 S310F [plasma membrane] (R-HSA-9665350)
      • ERBB2 S310Y [plasma membrane] (R-HSA-9665344)
      • p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381)
      • p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382)
      • p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379)
      • p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385)
      • p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268)
      • p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303)
      • p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618)
      • p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652)
      • p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695)
      • p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615)
      • p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833)
      • p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401)
      • p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194)
      • p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397)
      • p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398)
      • p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)
      		0.954 25
       UniProt:P21860 ERBB3      0.919 14
       UniProt:P40763 STAT3  12
      • p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554)
      • p-Y705-STAT3 [cytosol] (R-HSA-914048)
      • STAT3 [cytosol] (R-HSA-539044)
      • p-Y705-STAT3 [cytosol] (R-HSA-8983130)
      • p-Y705,S727-STAT3 [cytosol] (R-HSA-539048)
      • p-S727-STAT3 [cytosol] (R-HSA-198705)
      • p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589)
      • p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429)
      • AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435)
      • p-STAT3 [cytosol] (R-HSA-8982823)
      • p-STAT3 [nucleoplasm] (R-HSA-8983188)
      • Unfolded STAT3 [cytosol] (R-HSA-6813811)
      		0.919 15
       UniProt:P12931 SRC  6
      • MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)
      • MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598)
      • MyrG-SRC [plasma membrane] (R-HSA-8876922)
      • p-Y419-SRC [cytosol] (R-HSA-8964276)
      • SRC [cytosol] (R-HSA-9628701)
      • p-Y419-SRC [nucleoplasm] (R-HSA-8937690)
      		0.9 9
       UniProt:Q9UJM3 ERRFI      0.9 15
       UniProt:P18031 PTPN1  2
      • PTPN1 [endosome membrane] (R-HSA-9815895)
      • PTPN1 [cytosol] (R-HSA-210625)
      		0.898 9
       UniProt:P08238 HSP90AB1  6
      • HSP90AB1 [lysosomal lumen] (R-HSA-9622846)
      • HSP90AB1 [nucleoplasm] (R-HSA-5082399)
      • HSP90AB1 [cytosol] (R-HSA-419617)
      • HSP90AB1 [secretory granule lumen] (R-HSA-6801477)
      • HSP90AB1 [extracellular region] (R-HSA-6806463)
      • HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)
      		0.89 10
       UniProt:P27348 YWHAQ  1
      • YWHAQ [cytosol] (R-HSA-1445116)
      		0.854 7
       UniProt:P19174 PLCG1  6
      • p-4Y-PLCG1 [plasma membrane] (R-HSA-167679)
      • PLCG1 [cytosol] (R-HSA-202320)
      • PLCG1 [plasma membrane] (R-HSA-167682)
      • p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357)
      • p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)
      • p-Y-PLCG1 [cytosol] (R-HSA-9029082)
      		0.85 6
       UniProt:P31947 SFN  1
      • SFN [cytosol] (R-HSA-1445105)
      		0.833 9
       UniProt:P62158 CALM      0.828 6
       UniProt:Q96CW1 AP2M1  6
      • AP2M1 [plasma membrane] (R-HSA-167585)
      • AP2M1 [lysosomal membrane] (R-HSA-196144)
      • AP2M1 [cytosol] (R-HSA-182227)
      • AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423)
      • AP2M1 [endolysosome membrane] (R-HSA-6784828)
      • p-T156 AP2M1 [cytosol] (R-HSA-8856805)
      		0.828 8
       UniProt:P16333 NCK1  2
      • NCK1 [plasma membrane] (R-HSA-202992)
      • NCK1 [cytosol] (R-HSA-197954)
      		0.823 6
       UniProt:Q06124 PTPN11  4
      • p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)
      • PTPN11 [cytosol] (R-HSA-162563)
      • PTPN11 [nucleoplasm] (R-HSA-8937745)
      • p-Y542-PTPN11 [cytosol] (R-HSA-1369081)
      		0.821 8
       UniProt:P07948 LYN  7
      • LYN [cytosol] (R-HSA-354251)
      • MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875)
      • p-Y397-LYN [plasma membrane] (R-HSA-2454229)
      • p-Y397-LYN [cytosol] (R-HSA-8942608)
      • LYN [plasma membrane] (R-HSA-197943)
      • MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728)
      • MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903)
      		0.82 7
       UniProt:P15941 MUC1  19
      • MUC1(24-1255) [plasma membrane] (R-HSA-6793976)
      • Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219)
      • Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333)
      • Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231)
      • Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154)
      • Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068)
      • Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105)
      • extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019)
      • Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085)
      • MUC1(24-1255) [Golgi lumen] (R-HSA-913611)
      • Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518)
      • Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531)
      • Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483)
      • T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359)
      • Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526)
      • GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642)
      • Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286)
      • Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167)
      • GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)
      		0.819 6
       UniProt:Q03135 CAV1  5
      • CAV1 [Golgi membrane] (R-HSA-204504)
      • CAV1 [plasma membrane] (R-HSA-534994)
      • CAV1 [lipid droplet] (R-HSA-163510)
      • CAV1 [endocytic vesicle membrane] (R-HSA-535009)
      • CAV1 [early endosome membrane] (R-HSA-5368451)
      		0.813 7
       UniProt:O00750 PIK3C2B  1
      • PIK3C2B [cytosol] (R-HSA-1604619)
      		0.811 10
       UniProt:P27986 PIK3R1  16
      • PIK3R1 [plasma membrane] (R-HSA-198365)
      • PIK3R1 [cytosol] (R-HSA-74789)
      • K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572)
      • PIK3R1 R574T [plasma membrane] (R-HSA-2399540)
      • PIK3R1 R574I [plasma membrane] (R-HSA-2399536)
      • PIK3R1 D560H [plasma membrane] (R-HSA-2399432)
      • PIK3R1 N564K [plasma membrane] (R-HSA-2399431)
      • PIK3R1 K459del [plasma membrane] (R-HSA-2399554)
      • PIK3R1 N564D [plasma membrane] (R-HSA-2399427)
      • PIK3R1 D560Y [plasma membrane] (R-HSA-2399421)
      • PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544)
      • PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545)
      • PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546)
      • PIK3R1 K379E [plasma membrane] (R-HSA-8944148)
      • PIK3R1 G376R [plasma membrane] (R-HSA-2399717)
      • p-Y-PIK3R1 [cytosol] (R-HSA-9680647)
      		0.81 7
       UniProt:Q9UBN7 HDAC6  4
      • HDAC6 [lysosomal lumen] (R-HSA-9660002)
      • HDAC6 [cytosol] (R-HSA-5324660)
      • HDAC6 [late endosome lumen] (R-HSA-9659980)
      • HDAC6 [nucleoplasm] (R-HSA-351589)
      		0.809 12
       UniProt:Q05209 PTPN12  2
      • PTPN12 [cytosol] (R-HSA-432933)
      • PTPN12 [nucleoplasm] (R-HSA-9008905)
      		0.807 5
       UniProt:P11142 HSPA8  10
      • HSPA8 [cytosol] (R-HSA-264476)
      • HSPA8 [lysosomal lumen] (R-HSA-9625182)
      • HSPA8 [late endosome lumen] (R-HSA-9631104)
      • HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599)
      • HSPA8 [plasma membrane] (R-HSA-936508)
      • HSPA8 [nucleoplasm] (R-HSA-5082380)
      • HSPA8 [secretory granule lumen] (R-HSA-6801530)
      • HSPA8 [extracellular region] (R-HSA-6805936)
      • HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494)
      • Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217)
      		0.803 7
       UniProt:P20417  2
      • PTPN1 [cytosol] (R-RNO-210625)
      • PTPN1 [endosome membrane] (R-RNO-9815895)
      		0.802 11
       UniProt:P08581 MET  7
      • p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)
      • MET [plasma membrane] (R-HSA-419603)
      • p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689)
      • p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014)
      • MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180)
      • MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181)
      • p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032)
      		0.8 8
       UniProt:P08107 HSP71      0.799 6
       UniProt:Q92625 ANS1A      0.793 7
       UniProt:P16885 PLCG2  8
      • p-PLCG2 [plasma membrane] (R-HSA-114602)
      • PLCG2 [plasma membrane] (R-HSA-114601)
      • p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816)
      • PLCG2 [cytosol] (R-HSA-984806)
      • p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601)
      • p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640)
      • p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631)
      • p-Y-PLCG2 [cytosol] (R-HSA-9029105)
      		0.793 6
       UniProt:Q16543 CDC37  1
      • CDC37 [cytosol] (R-HSA-1221609)
      		0.786 13
       UniProt:P04406 GAPDH  1
      • GAPDH [cytosol] (R-HSA-70428)
      		0.785 7
       UniProt:P10599 TXN  4
      • TXN [cytosol] (R-HSA-66000)
      • 2xHC-TXN [cytosol] (R-HSA-73668)
      • TXN [nucleoplasm] (R-HSA-9617732)
      • 2xHC-TXN [nucleoplasm] (R-HSA-9617733)
      		0.785 5
       UniProt:P01135 TGFA  5
      • TGFA(24-98) [extracellular region] (R-HSA-9624183)
      • TGFA precursor [endoplasmic reticulum membrane] (R-HSA-5689476)
      • TGFA precursor [ER to Golgi transport vesicle membrane] (R-HSA-5689840)
      • TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689841)
      • TGFA(24-98) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628817)
      		0.779 4
       UniProt:P07900 HSP90AA1  8
      • HSP90AA1 [lysosomal lumen] (R-HSA-9622850)
      • HSP90AA1 [cytosol] (R-HSA-192864)
      • HSP90AA1 [nucleoplasm] (R-HSA-5082401)
      • HSP90AA1 [plasma membrane] (R-HSA-534996)
      • HSP90AA1 [secretory granule lumen] (R-HSA-6801515)
      • HSP90AA1 [extracellular region] (R-HSA-3221946)
      • HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470)
      • HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)
      		0.778 7
       UniProt:P42224 STAT1  8
      • STAT1 [cytosol] (R-HSA-629622)
      • p-Y701-STAT1 [cytosol] (R-HSA-3132766)
      • p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624)
      • p-Y701-STAT1 [cytosol] (R-HSA-8951202)
      • p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905)
      • p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842)
      • p-STAT1 [cytosol] (R-HSA-8950418)
      • p-STAT1 [nucleoplasm] (R-HSA-8987140)
      		0.774 7
       UniProt:Q9NRF2 SH2B1  1
      • SH2B1 [cytosol] (R-HSA-997253)
      		0.773 4
       UniProt:P63104 YWHAZ  2
      • YWHAZ [cytosol] (R-HSA-206099)
      • YWHAZ [nucleoplasm] (R-HSA-450469)
      		0.772 6
       UniProt:P04083 ANXA1  2
      • ANXA1 [cytosol] (R-HSA-5263630)
      • ANXA1 [extracellular region] (R-HSA-444539)
      		0.772 5
       UniProt:Q92569 PIK3R3  2
      • PIK3R3 [cytosol] (R-HSA-205223)
      • K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)
      		0.76 7
       UniProt:O00459 PIK3R2  3
      • PIK3R2 [cytosol] (R-HSA-74791)
      • K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554)
      • p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)
      		0.76 5
       UniProt:P46109 CRKL  2
      • CRKL [cytosol] (R-HSA-354384)
      • p-CRKL [cytosol] (R-HSA-9024730)
      		0.749 5
       UniProt:Q71U36 TUBA1A  9
      • TUBA1A [cytosol] (R-HSA-191689)
      • TUBA1A [axonemal microtubule] (R-HSA-5610433)
      • TUBA1A(1-450) [cytosol] (R-HSA-8955577)
      • Polyglutamyl-TUBA1A [cytosol] (R-HSA-8867408)
      • L-isoglutamyl polyglycyl-TUBA1A [cytosol] (R-HSA-8867428)
      • TUBA1A unfolded [cytosol] (R-HSA-392767)
      • TUBA1A folding intermediate [cytosol] (R-HSA-392805)
      • Ac K40 TUBA1A [axonemal microtubule] (R-HSA-5624852)
      • AcK-TUBA1A [cytosol] (R-HSA-5618312)
      		0.745 4
       UniProt:O60716 CTNND1  1
      • CTNND1 [plasma membrane] (R-HSA-418996)
      		0.745 5
       UniProt:Q05397 PTK2  11
      • p-6Y-PTK2 [cytosol] (R-HSA-354128)
      • p-Y397-PTK2 [cytosol] (R-HSA-354068)
      • PTK2 [cytosol] (R-HSA-201621)
      • PTK2(1-772) [cytosol] (R-HSA-202827)
      • PTK2(773-1052) [cytosol] (R-HSA-202829)
      • p-5Y-PTK2 [cytosol] (R-HSA-5218711)
      • p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006)
      • p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694)
      • pY-PTK2 [cytosol] (R-HSA-9632393)
      • p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600)
      • p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)
      		0.745 7
       UniProt:P38646 HSPA9  6
      • HSPA9(1-679) [cytosol] (R-HSA-1267964)
      • HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968)
      • HSPA9 [mitochondrial inner membrane] (R-HSA-1252206)
      • HSPA9 [mitochondrial matrix] (R-HSA-8878802)
      • HSPA9 [nucleoplasm] (R-HSA-5252128)
      • HSPA9 [cytosol] (R-HSA-5251993)
      		0.745 5
       UniProt:Q96JA1 LRIG1  2
      • Ub-LRIG1 [plasma membrane] (R-HSA-8875434)
      • LRIG1 [plasma membrane] (R-HSA-197745)
      		0.743 6
       UniProt:P26447 S10A4      0.743 6
       UniProt:Q92870 APBB2      0.737 7
       UniProt:Q9NSE2 CISH  1
      • CISH [cytosol] (R-HSA-1169213)
      		0.737 4
       UniProt:P12830 CDH1  8
      • CDH1(155-882) [plasma membrane] (R-HSA-198003)
      • CDH1(751-882) [plasma membrane] (R-HSA-202929)
      • CDH1(155-750) [plasma membrane] (R-HSA-202940)
      • p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938)
      • Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002)
      • CDH1(701-882) [extracellular region] (R-HSA-2534158)
      • CDH1(155-700) [plasma membrane] (R-HSA-2534244)
      • CDH1(732-882) [plasma membrane] (R-HSA-3827997)
      		0.735 4
       UniProt:Q13480 GAB1  4
      • p-Y-GAB1 [cytosol] (R-HSA-8855306)
      • p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496)
      • p-5Y-GAB1 [cytosol] (R-HSA-180344)
      • GAB1 [cytosol] (R-HSA-179795)
      		0.735 5
       UniProt:Q9UQB8 BAIAP2  1
      • BAIAP2 [cytosol] (R-HSA-442574)
      		0.735 4
       UniProt:Q13322 GRB10  2
      • p-Y GRB10 [cytosol] (R-HSA-9706168)
      • GRB10 [cytosol] (R-HSA-110009)
      		0.729 4
       UniProt:Q9UNE7 STUB1  1
      • STUB1 [cytosol] (R-HSA-975970)
      		0.721 4
       UniProt:Q12929 EPS8  1
      • EPS8 [cytosol] (R-HSA-9662382)
      		0.713 4
       UniProt:Q9P0L0 VAPA  4
      • VAPA [azurophil granule membrane] (R-HSA-6799364)
      • VAPA [plasma membrane] (R-HSA-6806269)
      • VAPA [endoplasmic reticulum membrane] (R-HSA-429677)
      • VAPA [cytosol] (R-HSA-9609920)
      		0.713 4
       UniProt:Q96B97 SH3KBP1  3
      • SH3KBP1 [plasma membrane] (R-HSA-182955)
      • SH3KBP1 [cytosol] (R-HSA-182957)
      • Ub-SH3KBP1 [cytosol] (R-HSA-182926)
      		0.695 4
       UniProt:Q13387 JIP2      0.692 5
       UniProt:P46108 CRK  1
      • CRK [cytosol] (R-HSA-2980677)
      		0.692 4
       UniProt:P23467 PTPRB  3
      • PTPRB [specific granule membrane] (R-HSA-6799638)
      • PTPRB [plasma membrane] (R-HSA-437247)
      • PTPRB [tertiary granule membrane] (R-HSA-6801032)
      		0.692 3
       UniProt:P43403 ZAP70  3
      • p-Y315,Y493-ZAP70 [cytosol] (R-HSA-202252)
      • p-Y493-ZAP70 [cytosol] (R-HSA-202368)
      • ZAP70 [cytosol] (R-HSA-202397)
      		0.692 3
       UniProt:P00519 ABL1  6
      • p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)
      • ABL1 [nucleoplasm] (R-HSA-5686579)
      • p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)
      • ABL1 [cytosol] (R-HSA-375987)
      • p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251)
      • p-Y393-ABL1 [cytosol] (R-HSA-9865161)
      		0.692 3
       UniProt:P51451 BLK  2
      • MyrG2-BLK [plasma membrane] (R-HSA-9606871)
      • BLK [cytosol] (R-HSA-983580)
      		0.692 3
       UniProt:Q13239 SLA  1
      • SLA [cytosol] (R-HSA-9706158)
      		0.692 3
       UniProt:P42684 ABL2  1
      • ABL2 [cytosol] (R-HSA-375998)
      		0.692 9
       UniProt:Q8TF42 UBS3B      0.69 7
       UniProt:Q14318 FKBP8  2
      • PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001)
      • FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)
      		0.683 4
       UniProt:Q68CZ2 TNS3  1
      • TNS3 [cytosol] (R-HSA-8875524)
      		0.683 5
       UniProt:P16234 PDGFRA  20
      • PDGFRA L629P [plasma membrane] (R-HSA-9673596)
      • PDGFRA N659K [plasma membrane] (R-HSA-9671535)
      • PDGFRA T674I [plasma membrane] (R-HSA-9673603)
      • PDGFRA S601P [plasma membrane] (R-HSA-9673600)
      • PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9671971)
      • PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673609)
      • p-11Y PDGFRA Y288C [endoplasmic reticulum membrane] (R-HSA-9672027)
      • p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane] (R-HSA-9673634)
      • PDGFRA D842_M844del [plasma membrane] (R-HSA-9671526)
      • PDGFRA D842Y [plasma membrane] (R-HSA-9671956)
      • PDGFRA D842V [plasma membrane] (R-HSA-9671549)
      • PDGFRA I843_D846del [plasma membrane] (R-HSA-9671537)
      • PDGFRA D842_H845del [plasma membrane] (R-HSA-9671545)
      • PDGFRA D842del [plasma membrane] (R-HSA-9671538)
      • PDGFRA D842_I843delinsV [plasma membrane] (R-HSA-9671563)
      • PDGFRA D846Y [plasma membrane] (R-HSA-9671958)
      • PDGFRA D843_845del [plasma membrane] (R-HSA-9671552)
      • PDGFRA D842_D846del [plasma membrane] (R-HSA-9671547)
      • PDGFRA N848K [plasma membrane] (R-HSA-9671961)
      • PDGFRA Y849C [plasma membrane] (R-HSA-9671974)
      		0.683 4
       UniProt:Q99962 SH3GL2  4
      • SH3GL2 [plasma membrane] (R-HSA-177495)
      • SH3GL2 [cytosol] (R-HSA-182958)
      • SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629)
      • SH3GL2 [Golgi membrane] (R-HSA-351189)
      		0.681 4
       UniProt:O75368 SH3L1      0.681 3
       UniProt:Q8WUM4 PDCD6IP  1
      • PDCD6IP [cytosol] (R-HSA-917717)
      		0.681 4
       UniProt:P41240 CSK  2
      • CSK [cytosol] (R-HSA-203776)
      • CSK [plasma membrane] (R-HSA-180499)
      		0.681 3
       UniProt:O60603 TLR2  3
      • TLR2 [plasma membrane] (R-HSA-167992)
      • TLR2 [secretory granule membrane] (R-HSA-6804777)
      • TLR2 [plasma membrane] (R-HSA-9637646)
      		0.681 3
       UniProt:P35221 CTNNA1  2
      • CTNNA1 [plasma membrane] (R-HSA-191735)
      • CTNNA1 [cytosol] (R-HSA-191697)
      		0.68 5
       UniProt:Q9UKV8 AGO2  2
      • AGO2 [cytosol] (R-HSA-209723)
      • AGO2 [nucleoplasm] (R-HSA-5578701)
      		0.679 11
       UniProt:O95782 AP2A1  5
      • AP2A1 [endolysosome membrane] (R-HSA-6784829)
      • AP2A1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5138449)
      • AP2A1 [cytosol] (R-HSA-182143)
      • AP2A1 [plasma membrane] (R-HSA-177494)
      • AP2A1 [endocytic vesicle membrane] (R-HSA-416641)
      		0.671 6
       UniProt:Q9UQC2 GAB2  5
      • p-Y643-GAB2 [cytosol] (R-HSA-9677149)
      • p-5Y-GAB2 [cytosol] (R-HSA-8855574)
      • GAB2 [cytosol] (R-HSA-508239)
      • p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615)
      • p-Y-GAB2 [cytosol] (R-HSA-912529)
      		0.669 3
       UniProt:Q07889 SOS1  3
      • SOS1 [cytosol] (R-HSA-64847)
      • SOS1 [plasma membrane] (R-HSA-983559)
      • p-4S-SOS1 [cytosol] (R-HSA-109821)
      		0.669 3
       UniProt:P34932 HSPA4  2
      • HSPA4 [cytosol] (R-HSA-5251946)
      • HSPA4 [nucleoplasm] (R-HSA-5251998)
      		0.668 3
       UniProt:P23528 CFL1  3
      • CFL1 [cytosol] (R-HSA-350751)
      • p-S3-CFL1 [cytosol] (R-HSA-399813)
      • CFL1 [extracellular region] (R-HSA-350747)
      		0.668 3
       UniProt:Q09666 AHNK      0.667 4
       UniProt:P51636 CAV2  2
      • CAV2 [plasma membrane] (R-HSA-9021035)
      • CAV2 [Golgi membrane] (R-HSA-9021032)
      		0.667 3
       UniProt:P06493 CDK1  11
      • p-T161-CDK1 [nucleoplasm] (R-HSA-170066)
      • p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074)
      • p-T161-CDK1 [cytosol] (R-HSA-157415)
      • p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071)
      • CDK1 [cytosol] (R-HSA-170075)
      • CDK1 [nucleoplasm] (R-HSA-68889)
      • p-T14-CDK1 [cytosol] (R-HSA-170064)
      • p-T14-CDK1 [nucleoplasm] (R-HSA-170045)
      • p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078)
      • p-Y4-CDK1 [cytosol] (R-HSA-9836187)
      • CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)
      		0.667 3
       UniProt:Q9NZM3 ITSN2  1
      • ITSN2 [cytosol] (R-HSA-8862264)
      		0.653 3
       UniProt:Q15750 TAB1  6
      • TAB1 [cytosol] (R-HSA-167923)
      • TAB1 [endosome membrane] (R-HSA-450238)
      • TAB1(1-444) [cytosol] (R-HSA-9729751)
      • TAB1(1-132) [cytosol] (R-HSA-9729698)
      • TAB1(133-504) [cytosol] (R-HSA-9729724)
      • TAB1(445-504) [cytosol] (R-HSA-9729691)
      		0.653 3
       UniProt:P14923 JUP  6
      • JUP [plasma membrane] (R-HSA-437260)
      • JUP [specific granule lumen] (R-HSA-6799534)
      • JUP [extracellular region] (R-HSA-6806309)
      • JUP [ficolin-1-rich granule lumen] (R-HSA-6801028)
      • JUP [cornified envelope] (R-HSA-8847739)
      • JUP [cytosol] (R-HSA-201598)
      		0.653 3
       UniProt:P15311 EZR  3
      • p-Y146,Y354-EZR [cytosol] (R-HSA-374572)
      • p-T567-EZR [cytosol] (R-HSA-374559)
      • EZR [cytosol] (R-HSA-9020826)
      		0.653 3
       UniProt:P08631 HCK  2
      • p-HCK [cytosol] (R-HSA-9676060)
      • HCK [cytosol] (R-HSA-167708)
      		0.653 3
       UniProt:Q10567 AP1B1  5
      • AP1B1 [cytoplasmic vesicle membrane] (R-HSA-351181)
      • AP1B1 [Golgi membrane] (R-HSA-350809)
      • AP1B1 [lysosomal membrane] (R-HSA-432699)
      • AP1B1 [trans-Golgi network membrane] (R-HSA-2130596)
      • AP1B1 [cytosol] (R-HSA-167705)
      		0.649 4
       UniProt:Q8NBJ4 GOLM1  2
      • p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938)
      • GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)
      		0.644 13
       UniProt:P08195 SLC3A2  1
      • SLC3A2 [plasma membrane] (R-HSA-352179)
      		0.643 5
       UniProt:P16615 ATP2A2  2
      • ATP2A2 [platelet dense tubular network membrane] (R-HSA-427903)
      • ATP2A2 [endoplasmic reticulum membrane] (R-HSA-391962)
      		0.643 3
       UniProt:P60520 GABARAPL2  3
      • GABARAPL2 [cytosol] (R-HSA-5671758)
      • GABARAPL2(1-117) [cytosol] (R-HSA-5682641)
      • GABARAPL2 [autophagosome membrane] (R-HSA-5683633)
      		0.635 3
       UniProt:P04150 NR3C1  3
      • SUMO1-K277,K293-NR3C1 [nucleoplasm] (R-HSA-4341106)
      • NR3C1 [cytosol] (R-HSA-5618118)
      • NR3C1 [nucleoplasm] (R-HSA-879837)
      		0.635 3
       UniProt:P18433 PTPRA  1
      • PTPRA [plasma membrane] (R-HSA-388755)
      		0.635 3
       UniProt:Q9Y2H9 MAST1      0.635 3
       UniProt:P42229 STAT5A  4
      • STAT5A [cytosol] (R-HSA-380747)
      • p-Y694-STAT5A [cytosol] (R-HSA-507936)
      • p-Y694-STAT5A [nucleoplasm] (R-HSA-507995)
      • STAT5A [nucleoplasm] (R-HSA-9701901)
      		0.635 4
       UniProt:P17252 PRKCA  8
      • PRKCA [cytosol] (R-HSA-58196)
      • PRKCA [plasma membrane] (R-HSA-156469)
      • pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340)
      • p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292)
      • p-T497-PRKCA [cytosol] (R-HSA-5218731)
      • p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337)
      • PRKCA [photoreceptor disc membrane] (R-HSA-2648987)
      • PRKCA [nucleoplasm] (R-HSA-450530)
      		0.635 3
       UniProt:P49069 CAMLG  1
      • CAMLG [endoplasmic reticulum membrane] (R-HSA-9609522)
      		0.635 3
       UniProt:Q6S5L8 SHC4      0.635 3
       UniProt:Q9Y2R2 PTPN22  1
      • PTPN22 [cytosol] (R-HSA-8852205)
      		0.635 3
       UniProt:Q8WUI4 HDAC7  1
      • HDAC7 [nucleoplasm] (R-HSA-3004534)
      		0.635 3
       UniProt:Q02952 AKAP12  1
      • AKAP12 [plasma membrane] (R-HSA-9715082)
      		0.635 3
       UniProt:Q9BRG2 SH23A      0.635 3
       UniProt:P09936 UCHL1  1
      • UCHL1 [cytosol] (R-HSA-5660679)
      		0.635 3
       UniProt:P31948 STIP1  1
      • STIP1 [cytosol] (R-HSA-443857)
      		0.635 3
       UniProt:O43561 LAT  3
      • p-Y200,Y220-LAT [plasma membrane] (R-HSA-434829)
      • LAT [plasma membrane] (R-HSA-202322)
      • p-5Y-LAT [plasma membrane] (R-HSA-202364)
      		0.635 3
       UniProt:Q14247 CTTN  2
      • CTTN [cytosol] (R-HSA-201894)
      • p-S113-CTTN [cytosol] (R-HSA-442842)
      		0.635 4
       UniProt:Q13094 LCP2  2
      • p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)
      • LCP2 [cytosol] (R-HSA-202306)
      		0.635 3
       UniProt:P09769 FGR  3
      • FGR [cytosol] (R-HSA-432116)
      • FGR [secretory granule lumen] (R-HSA-6804974)
      • FGR [extracellular region] (R-HSA-6806524)
      		0.635 3
       UniProt:O75791 GRAP2  1
      • GRAP2 [cytosol] (R-HSA-202367)
      		0.635 3
       UniProt:Q12933 TRAF2  5
      • TRAF2 [cytosol] (R-HSA-66370)
      • PolyUb-TRAF2 [cytosol] (R-HSA-6782848)
      • K63polyUb-TRAF2 [cytosol] (R-HSA-8862193)
      • K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194)
      • TRAF2 [nucleoplasm] (R-HSA-8862199)
      		0.635 4
       UniProt:Q14457 BECN1  4
      • BECN1 [cytosol] (R-HSA-1632841)
      • p-S15-BECN1 [cytosol] (R-HSA-5682391)
      • ISG15-K-BECN1 [cytosol] (R-HSA-9853030)
      • K63polyUb-BECN1 [cytosol] (R-HSA-6782989)
      		0.628 7
       UniProt:P46940 IQGAP1  3
      • IQGAP1 [cytosol] (R-HSA-5626371)
      • IQGAP1 [secretory granule membrane] (R-HSA-6804803)
      • IQGAP1 [plasma membrane] (R-HSA-381681)
      		0.626 4
       UniProt:Q13438 OS9  1
      • OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)
      		0.623 3
       UniProt:Q12852 M3K12      0.621 3
       UniProt:Q6UW88 EPGN  2
      • EPGN(23-154) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628815)
      • EPGN(23-154) [extracellular region] (R-HSA-9624187)
      		0.618 3
       UniProt:O14944 EREG  2
      • EREG(60-108) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628816)
      • EREG(60-108) [extracellular region] (R-HSA-1233233)
      		0.618 3
       UniProt:P04792 HSBP1  3
      • HSPB1 [cytosol] (R-HSA-450563)
      • p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697)
      • p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)
      		0.615 3
       UniProt:Q99075 HBEGF  8
      • HBEGF(63-148) [clathrin-coated endocytic vesicle membrane] (R-HSA-9628819)
      • HBEGF(20-208) [clathrin-coated endocytic vesicle membrane] (R-HSA-5334782)
      • HBEGF(20-208) [endocytic vesicle membrane] (R-HSA-5334776)
      • HB-EGF(161-208) [plasma membrane] (R-HSA-9624270)
      • HBEGF(20-62) [extracellular region] (R-HSA-2179390)
      • HBEGF(149-208) [extracellular region] (R-HSA-2179391)
      • HBEGF(20-208) [plasma membrane] (R-HSA-2179406)
      • HBEGF(63-148) [extracellular region] (R-HSA-1233234)
      		0.609 3
       UniProt:Q9UJ41 RABGEF1  2
      • RABGEF1 [early endosome membrane] (R-HSA-2029032)
      • RABGEF1 [cytosol] (R-HSA-8875419)
      		0.599 4
       UniProt:Q86VI4 LAP4B      0.599 10
       UniProt:P60033 CD81  1
      • CD81 [plasma membrane] (R-HSA-197933)
      		0.597 6
       UniProt:P08575 PTPRC  2
      • PTPRC [plasma membrane] (R-HSA-197931)
      • PTPRC [secretory granule membrane] (R-HSA-6806150)
      		0.592 2
       UniProt:P14174 MIF  3
      • MIF [secretory granule lumen] (R-HSA-6803282)
      • MIF [extracellular region] (R-HSA-212594)
      • MIF [ficolin-1-rich granule lumen] (R-HSA-6803289)
      		0.591 3
       UniProt:Q8IZW8 TNS4  1
      • TNS4 [cytosol] (R-HSA-201624)
      		0.59 2
       UniProt:P07355 ANXA2  6
      • ANXA2 [azurophil granule lumen] (R-HSA-6798766)
      • ANXA2 [extracellular region] (R-HSA-6806242)
      • p-S26-ANXA2 [cytosol] (R-HSA-9865163)
      • p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224)
      • ANXA2 [external side of plasma membrane] (R-HSA-5336164)
      • ANXA2 [cytosol] (R-HSA-5263667)
      		0.583 4
       UniProt:O75886 STAM2  2
      • Ub-STAM2 [cytosol] (R-HSA-6782781)
      • STAM2 [cytosol] (R-HSA-182965)
      		0.583 3
       UniProt:P29353-7 SHC1      0.581 4
       UniProt:O14965 AURKA  6
      • p-T288-AURKA [cytosol] (R-HSA-2574832)
      • AURKA [cytosol] (R-HSA-174254)
      • p-T288-AURKA [nucleoplasm] (R-HSA-6805089)
      • AURKA [nucleoplasm] (R-HSA-4655443)
      • PolyUb-AURKA [cytosol] (R-HSA-8854040)
      • SUMO1-K258-AURKA [cytosol] (R-HSA-4655367)
      		0.581 4
       UniProt:Q01973 ROR1  2
      • ROR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140727)
      • ROR1 [plasma membrane] (R-HSA-197814)
      		0.576 8
       UniProt:P23470 PTPRG      0.573 3
       UniProt:Q9UKG1 APPL1  1
      • APPL1 [endosome membrane] (R-HSA-373630)
      		0.571 3
       UniProt:Q9Y6R0 NUMBL      0.571 2
       UniProt:P49757 NUMB  1
      • NUMB [plasma membrane] (R-HSA-443595)
      		0.571 2
       UniProt:P07992 ERCC1  2
      • Ub-ERCC1 [nucleoplasm] (R-HSA-5696473)
      • ERCC1 [nucleoplasm] (R-HSA-54427)
      		0.571 21
       UniProt:P63010 AP2B1  4
      • AP2B1 [endolysosome membrane] (R-HSA-6784827)
      • AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489)
      • AP2B1 [cytosol] (R-HSA-182166)
      • AP2B1 [plasma membrane] (R-HSA-167690)
      		0.569 5
       UniProt:P53680 AP2S1  4
      • AP2S1 [endolysosome membrane] (R-HSA-6784821)
      • AP2S1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130707)
      • AP2S1 [cytosol] (R-HSA-182197)
      • AP2S1 [plasma membrane] (R-HSA-389382)
      		0.569 3
       UniProt:O94973 AP2A2  6
      • AP2A2(1-939) [endolysosome membrane] (R-HSA-6784819)
      • AP2A2(1-939) [secretory granule membrane] (R-HSA-6800412)
      • AP2A2(1-939) [ficolin-1-rich granule membrane] (R-HSA-6800414)
      • AP2A2(1-939) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138448)
      • AP2A2(1-939) [cytosol] (R-HSA-182155)
      • AP2A2(1-939) [plasma membrane] (R-HSA-177502)
      		0.569 4
       UniProt:hspa1a_hspa1b_human-1 EBI-11820565      0.569 3
       UniProt:Q9UBS4 DNAJB11  1
      • DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)
      		0.569 3
       UniProt:Q92622 RUBIC      0.564 3
       UniProt:Q15303 ERBB4      0.564 3
       UniProt:P07947 YES1  2
      • MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411)
      • YES1 [cytosol] (R-HSA-373640)
      		0.564 3
       UniProt:Q13451 FKBP5  2
      • FKBP5 [nucleoplasm] (R-HSA-8939165)
      • FKBP5 [cytosol] (R-HSA-5618096)
      		0.564 2
       UniProt:P62994 Grb2  3
      • Grb2 [cytosol] (R-RNO-55929)
      • Grb2 [plasma membrane] (R-RNO-202993)
      • Grb2 [cytosol] (R-RNO-74686)
      		0.564 5
       UniProt:Q8IZV2 CKLF8      0.556 3
       UniProt:O75674 TM1L1      0.556 6
       UniProt:Q05513 PRKCZ  5
      • pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)
      • PRKCZ [cytosol] (R-HSA-58218)
      • p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698)
      • p-T410-PRKCZ [cytosol] (R-HSA-437181)
      • PRKCZ [cell junction] (R-HSA-2134483)
      		0.553 2
       UniProt:P05107 ITGB2  4
      • ITGB2 [plasma membrane] (R-HSA-198010)
      • ITGB2 [ficolin-1-rich granule membrane] (R-HSA-6803310)
      • ITGB2 [specific granule membrane] (R-HSA-6803284)
      • ITGB2 [tertiary granule membrane] (R-HSA-6803342)
      		0.553 2
       UniProt:P40925 MDH1  1
      • MDH1 [cytosol] (R-HSA-198471)
      		0.553 2
       UniProt:Q99608 NDN  1
      • NDN [nucleoplasm] (R-HSA-6789966)
      		0.553 2
       UniProt:Q9H299 SH3L3      0.553 2
       UniProt:Q8N111 CEND      0.553 2
       UniProt:Q59GR8 Q59GR8      0.553 2
       UniProt:Q14204 DYNC1H1  3
      • DYNC1H1 [cytosol] (R-HSA-380285)
      • DYNC1H1 [azurophil granule lumen] (R-HSA-6799155)
      • DYNC1H1 [extracellular region] (R-HSA-6806223)
      		0.553 2
       UniProt:P16930 FAH  1
      • FAH [cytosol] (R-HSA-71174)
      		0.553 2
       UniProt:Q59G22 Q59G22      0.553 2
       UniProt:Q13491 GPM6B      0.553 2
       UniProt:A4FU49 SH321      0.553 2
       UniProt:P60174 TPI1  1
      • TPI1 [cytosol] (R-HSA-70451)
      		0.553 2
       UniProt:O95433 AHSA1      0.553 2
       UniProt:Q7L273 KCTD9      0.553 2
       UniProt:Q4KWH8 PLCH1  1
      • PLCH1 [plasma membrane] (R-HSA-2023859)
      		0.553 2
       UniProt:O15511 ARPC5  4
      • ARPC5 [ficolin-1-rich granule lumen] (R-HSA-6801065)
      • ARPC5 [extracellular region] (R-HSA-6806476)
      • ARPC5 [secretory granule lumen] (R-HSA-6801071)
      • ARPC5 [cytosol] (R-HSA-200806)
      		0.553 2
       UniProt:Q99759 MAP3K3  1
      • MAP3K3 [cytosol] (R-HSA-507725)
      		0.553 2
       UniProt:P31321 PRKAR1B  2
      • PRKAR1B [cytosol] (R-HSA-57838)
      • PRKAR1B [ciliary base] (R-HSA-5610409)
      		0.553 2
       UniProt:P19438 TNFRSF1A  2
      • TNFRSF1A(41-201) [extracellular region] (R-HSA-6785048)
      • TNFRSF1A(30-45) [plasma membrane] (R-HSA-5675738)
      		0.553 2
       UniProt:Q16186 ADRM1  2
      • ADRM1 [cytosol] (R-HSA-5665939)
      • ADRM1 [nucleoplasm] (R-HSA-9918361)
      		0.553 2
       UniProt:P06132 UROD  1
      • UROD [cytosol] (R-HSA-189427)
      		0.553 2
       UniProt:P04075 ALDOA  6
      • ALDOA [platelet alpha granule lumen] (R-HSA-349738)
      • ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521)
      • ALDOA [tertiary granule lumen] (R-HSA-6801485)
      • ALDOA [extracellular region] (R-HSA-349735)
      • ALDOA [secretory granule lumen] (R-HSA-6801469)
      • ALDOA [cytosol] (R-HSA-71492)
      		0.553 2
       UniProt:P41222 PTGDS  1
      • PTGDS [endoplasmic reticulum membrane] (R-HSA-2142814)
      		0.553 2
       UniProt:Q8TDI0 CHD5      0.553 2
       UniProt:Q02790 FKBP4  3
      • FKBP4 [nucleoplasm] (R-HSA-8939162)
      • FKBP4 [nucleoplasm] (R-HSA-5324621)
      • FKBP4 [cytosol] (R-HSA-5618108)
      		0.553 2
       UniProt:P06396 GSN  7
      • GSN [cytosol] (R-HSA-350275)
      • GSN(28-403) [cytosol] (R-HSA-201618)
      • GSN(404-782) [cytosol] (R-HSA-350272)
      • GSN [secretory granule lumen] (R-HSA-6801486)
      • GSN [extracellular region] (R-HSA-6806510)
      • GSN [ficolin-1-rich granule lumen] (R-HSA-6801465)
      • GSN(200-270) [extracellular region] (R-HSA-976940)
      		0.553 2
       UniProt:Q8N2Y8 RUSC2      0.553 2
       UniProt:P05067 APP  20
      • APP(672-713) [extracellular region] (R-HSA-879340)
      • APP(672-711) [cytosol] (R-HSA-877188)
      • APP(672-711) [extracellular region] (R-HSA-976740)
      • APP [endoplasmic reticulum lumen] (R-HSA-8956696)
      • p-APP [endoplasmic reticulum lumen] (R-HSA-8957012)
      • APP(18-770) [endosome lumen] (R-HSA-5229077)
      • APP(672-711) [endosome lumen] (R-HSA-6783333)
      • APP(672-713) [endosome lumen] (R-HSA-5692993)
      • APP(672-770) [endosome lumen] (R-HSA-9010082)
      • APP(712-770) [endosome lumen] (R-HSA-6783331)
      • APP(714-770) [endosome lumen] (R-HSA-6783325)
      • APP(18-671) [endosome lumen] (R-HSA-5693003)
      • APP(18-770) [plasma membrane] (R-HSA-9010038)
      • APP(18-770) [Golgi lumen] (R-HSA-8871509)
      • APP(688-770) [plasma membrane] (R-HSA-9010028)
      • APP(18-687) [extracellular region] (R-HSA-9010033)
      • APP(18-770) [platelet alpha granule lumen] (R-HSA-139835)
      • APP(18-770) [extracellular region] (R-HSA-49335)
      • APP-C99 [cytosol] (R-HSA-9617603)
      • APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)
      		0.553 2
       UniProt:Q13561 DCTN2  1
      • DCTN2 [cytosol] (R-HSA-380302)
      		0.553 2
       UniProt:Q53GZ6 Q53GZ6      0.553 2
       UniProt:P17600 SYN1  2
      • SYN1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-9659624)
      • SYN1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-380577)
      		0.553 2
       UniProt:P31939 ATIC  5
      • ATIC(1-230)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710833)
      • ATIC(1-229)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9710847)
      • ATIC(1-230)-ALK(1059-1620) fusion [cytosol] (R-HSA-9710832)
      • ATIC(1-229)-ALK(1058-1620) fusion [cytosol] (R-HSA-9710829)
      • ATIC [cytosol] (R-HSA-62506)
      		0.553 2
       UniProt:Q08881 ITK  3
      • ITK [cytosol] (R-HSA-202319)
      • p-Y512-ITK [cytosol] (R-HSA-422519)
      • p-Y180,Y512-ITK [cytosol] (R-HSA-2685616)
      		0.553 2
       UniProt:P54368 OAZ1  1
      • OAZ1 [cytosol] (R-HSA-350587)
      		0.553 2
       UniProt:Q9UPY6 WASF3  3
      • p-Y151,S,T-WASF3 [cytosol] (R-HSA-5672385)
      • p-Y151-WASF3 [cytosol] (R-HSA-2029006)
      • WASF3 [cytosol] (R-HSA-200975)
      		0.553 2
       UniProt:P17174 GOT1  1
      • PXLP-K259-GOT1 [cytosol] (R-HSA-1295497)
      		0.553 2
       UniProt:Q9NNZ3 DNJC4      0.553 2
       UniProt:Q9Y5X1 SNX9  3
      • SNX9 [cytosol] (R-HSA-8867737)
      • SNX9 [Golgi membrane] (R-HSA-432988)
      • SNX9 [cytoplasmic vesicle membrane] (R-HSA-432990)
      		0.553 2
       UniProt:Q14050 COL9A3  20
      • GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179198)
      • GalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179194)
      • 3x4Hyp-3Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179210)
      • 3x4Hyp-GlcGalHyl-COL9A3 [endoplasmic reticulum lumen] (R-HSA-2179209)
      • COL9A3 [extracellular region] (R-HSA-375063)
      • 3Hyp-4Hyp-COL9A3 [extracellular region] (R-HSA-2193009)
      • GalHyl-COL9A3 [extracellular region] (R-HSA-2192976)
      • 3x4Hyp-COL9A3 [extracellular region] (R-HSA-2192931)
      • 3x4Hyp-3Hyp-GalHyl-COL9A3 [extracellular region] (R-HSA-2192946)
      • 3x4Hyp-3Hyp-GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192978)
      • GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192962)
      • 3x4Hyp-5Hyl-COL9A3 [extracellular region] (R-HSA-2193029)
      • 3x4Hyp-GlcGalHyl-COL9A3 [extracellular region] (R-HSA-2192981)
      • 3x4Hyp-3Hyp-5Hyl-COL9A3 [extracellular region] (R-HSA-2193030)
      • 3x4Hyp-GalHyl-COL9A3 [extracellular region] (R-HSA-2193003)
      • 5Hyl-COL9A3 [extracellular region] (R-HSA-2193022)
      • 3x4Hyp-GalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470434)
      • 3x4Hyp-3Hyp-GalHyl-COL9A3(26-?) [extracellular region] (R-HSA-2470413)
      • 3x4Hyp-COL9A3(?-684) [extracellular region] (R-HSA-2470381)
      • GalHyl-COL9A3(?-684) [extracellular region] (R-HSA-2470412)
      		0.553 2
       UniProt:O94992 HEXI1      0.553 2
       UniProt:O43639 NCK2  1
      • NCK2 [cytosol] (R-HSA-204885)
      		0.553 2
       UniProt:Q9Y3A3 PHOCN      0.553 2
       UniProt:Q96AD5 PNPLA2  4
      • PNPLA2 [lipid droplet] (R-HSA-9859603)
      • p-PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956923)
      • PNPLA2 [endoplasmic reticulum lumen] (R-HSA-8956776)
      • PNPLA2 [endoplasmic reticulum membrane] (R-HSA-1498814)
      		0.553 2
       UniProt:O94875 SRBS2      0.553 2
       UniProt:P07949 RET  2
      • RET [plasma membrane] (R-HSA-8853797)
      • p-5Y-RET [plasma membrane] (R-HSA-8854162)
      		0.553 2
       UniProt:Q15819 UBE2V2  2
      • UBE2V2 [cytosol] (R-HSA-947624)
      • UBE2V2 [nucleoplasm] (R-HSA-5682543)
      		0.553 2
       UniProt:P45984 MAPK9  3
      • MAPK9 [cytosol] (R-HSA-450355)
      • p-T183,Y185-MAPK9 [cytosol] (R-HSA-450293)
      • p-T183,Y185-MAPK9 [nucleoplasm] (R-HSA-450319)
      		0.553 2
       UniProt:Q6UWJ1 TMCO3      0.553 2
       UniProt:Q99784 NOE1      0.553 2
       UniProt:Q92918 M4K1      0.553 2
       UniProt:Q07890 SOS2  1
      • SOS2 [cytosol] (R-HSA-167221)
      		0.553 2
       UniProt:P49798 RGS4  1
      • RGS4 [plasma membrane] (R-HSA-921135)
      		0.553 2
       UniProt:O75095 MEGF6      0.553 2
       UniProt:Q15120 PDK3  1
      • PDK3(?-406) [mitochondrial matrix] (R-HSA-203940)
      		0.553 2
       UniProt:O43707 ACTN4  3
      • ACTN4 [extracellular region] (R-HSA-349729)
      • ACTN4 [platelet alpha granule lumen] (R-HSA-198240)
      • ACTN4 [cytosol] (R-HSA-390558)
      		0.553 2
       UniProt:Q8N5H7 SH2D3      0.553 2
       UniProt:Q02297 NRG1  1
      • NRG1 [extracellular region] (R-HSA-1227951)
      		0.553 2
       UniProt:P62330 ARF6  2
      • ARF6 [recycling endosome membrane] (R-HSA-2029049)
      • ARF6 [cytosol] (R-HSA-8871121)
      		0.553 2
       UniProt:P52306 RAP1GDS1  1
      • RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)
      		0.553 2
       UniProt:Q15005 SPCS2  1
      • SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)
      		0.553 2
       UniProt:Q92733 PRCC  1
      • PRCC [nucleoplasm] (R-HSA-8867896)
      		0.553 2
       UniProt:Q9Y6K9 IKBKG  12
      • IKBKG [cytosol] (R-HSA-168108)
      • Ub-285-IKBKG [cytosol] (R-HSA-741397)
      • K63polyUb-IKBKG [cytosol] (R-HSA-202530)
      • IKBKG [nucleoplasm] (R-HSA-4755413)
      • monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449)
      • IKBKG *420Wext*447 [cytosol] (R-HSA-5262978)
      • IKBKG R175P [cytosol] (R-HSA-5262916)
      • IKBKG R173G [cytosol] (R-HSA-5262966)
      • IKBKG C417R [cytosol] (R-HSA-5262858)
      • IKBKG E391* [cytosol] (R-HSA-5262924)
      • IKBKG L153R [cytosol] (R-HSA-5262879)
      • IKBKG D406V [cytosol] (R-HSA-5262943)
      		0.553 2
       UniProt:Q59EJ3 Q59EJ3      0.553 2
       UniProt:P43243 MATR3      0.553 2
       UniProt:P53041 PPP5C  2
      • PPP5C [nucleoplasm] (R-HSA-5683410)
      • PPP5C [cytosol] (R-HSA-5675402)
      		0.553 2
       UniProt:P49908 SELENOP  2
      • SEPP1 [extracellular region] (R-HSA-8848887)
      • SEPP1 [platelet dense granule lumen] (R-HSA-8848897)
      		0.553 2
       UniProt:Q8TDB4 HUMMR      0.553 2
       UniProt:Q02156 PRKCE  2
      • p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)
      • PRKCE [cytosol] (R-HSA-58202)
      		0.553 2
       UniProt:Q9Y237 PIN4      0.553 2
       UniProt:Q07954 LRP1  2
      • LRP1 [endocytic vesicle membrane] (R-HSA-2230981)
      • LRP1 [plasma membrane] (R-HSA-1454844)
      		0.553 2
       UniProt:Q14155 ARHGEF7  1
      • ARHGEF7 [cytosol] (R-HSA-430346)
      		0.553 2
       UniProt:P42685 FRK  4
      • p-Y387-FRK [cytosol] (R-HSA-8847965)
      • FRK [specific granule lumen] (R-HSA-6801037)
      • FRK [extracellular region] (R-HSA-6806235)
      • FRK [azurophil granule lumen] (R-HSA-6799142)
      		0.553 2
       UniProt:P20336 RAB3A  9
      • RAB3A [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372512)
      • RAB3A [plasma membrane] (R-HSA-210461)
      • RAB3A [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917743)
      • RAB3A [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210466)
      • RAB3A [secretory granule membrane] (R-HSA-6804968)
      • RAB3A [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-379365)
      • RAB3A [cytosol] (R-HSA-8870410)
      • GGC-RAB3A [cytosol] (R-HSA-8870429)
      • GGC-RAB3A [secretory granule membrane] (R-HSA-8875319)
      		0.553 2
       UniProt:P52630 STAT2  4
      • p-Y690-STAT2 [cytosol] (R-HSA-909683)
      • STAT2 [cytosol] (R-HSA-882029)
      • p-Y690-STAT2 [nucleoplasm] (R-HSA-909673)
      • p-Y-STAT2 [cytosol] (R-HSA-8987235)
      		0.553 2
       UniProt:P60880 SNAP25  7
      • SNAP25(1-197) [plasma membrane] (R-HSA-3004546)
      • SNAP25(198-206) [cytosol] (R-HSA-5244499)
      • SNAP25(1-198) [plasma membrane] (R-HSA-3004550)
      • SNAP25(199-206) [cytosol] (R-HSA-5244501)
      • SNAP25 [tertiary granule membrane] (R-HSA-6806142)
      • SNAP25 [specific granule membrane] (R-HSA-6806154)
      • SNAP25 [plasma membrane] (R-HSA-2029017)
      		0.553 2
       UniProt:P15498 VAV1  5
      • VAV1 [plasma membrane] (R-HSA-1045153)
      • VAV1 [cytosol] (R-HSA-195066)
      • p-Y174-VAV1 [cytosol] (R-HSA-437946)
      • p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323)
      • p-Y-VAV1 [cytosol] (R-HSA-9029087)
      		0.553 2
       UniProt:P21291 CSRP1  1
      • CSRP1 [nucleoplasm] (R-HSA-5660398)
      		0.553 2
       UniProt:Q13153 PAK1  5
      • p-S144,T423-PAK1 [cytosol] (R-HSA-399819)
      • PAK1 [cytosol] (R-HSA-162629)
      • Active PAK1 [cytosol] (R-HSA-8964622)
      • p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472)
      • PAK1 [plasma membrane] (R-HSA-3928409)
      		0.553 2
       UniProt:O14818 PSMA7  2
      • PSMA7 [nucleoplasm] (R-HSA-174351)
      • PSMA7 [cytosol] (R-HSA-68736)
      		0.553 2
       UniProt:Q13905 RAPGEF1  2
      • RAPGEF1 [cytosol] (R-HSA-913472)
      • RAPGEF1 [endosome] (R-HSA-3008667)
      		0.553 2
       UniProt:Q99952 PTPN18  2
      • PTPN18 [nucleoplasm] (R-HSA-9008900)
      • PTPN18 [cytosol] (R-HSA-8864101)
      		0.553 2
       UniProt:Q99704 DOK1  2
      • p-Y362-DOK1 [cytosol] (R-HSA-8848784)
      • DOK1 [cytosol] (R-HSA-74763)
      		0.553 2
       UniProt:P55036 PSMD4  1
      • PSMD4 [cytosol] (R-HSA-68800)
      		0.553 2
       UniProt:P30307 CDC25C  8
      • p-S198-CDC25C [nucleoplasm] (R-HSA-156668)
      • p-S198-CDC25C [cytosol] (R-HSA-8981697)
      • CDC25C [cytosol] (R-HSA-157879)
      • CDC25C [nucleoplasm] (R-HSA-69741)
      • p-S216-CDC25C [nucleoplasm] (R-HSA-156496)
      • p-S216-CDC25C [cytosol] (R-HSA-75003)
      • p-S191-CDC25C [nucleoplasm] (R-HSA-6802968)
      • p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654)
      		0.553 2
       UniProt:Q02246 CNTN2  1
      • CNTN2 [plasma membrane] (R-HSA-373618)
      		0.553 2
       UniProt:O14543 SOCS3  1
      • SOCS3 [cytosol] (R-HSA-873794)
      		0.553 2
       UniProt:P26641 EEF1G  3
      • EEF1G(1-343)-p-6Y-ALK(1106-1620) fusion [cytosol] (R-HSA-9710850)
      • EEF1G(1-343)-ALK(1106-1620) fusion [cytosol] (R-HSA-9710839)
      • EEF1G [cytosol] (R-HSA-156925)
      		0.553 2
       UniProt:Q9UGK3 STAP2  2
      • STAP2 [cytosol] (R-HSA-8848028)
      • p-Y250-STAP2 [plasma membrane] (R-HSA-8848079)
      		0.553 2
       UniProt:P10636 MAPT  3