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RPS6KB2 [nucleoplasm]
Stable Identifier
R-HSA-199877
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ribosomal protein S6 kinase 2, K6B2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant phosphorylates RSK (Homo sapiens)
RPS6KB2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the nucleus (Homo sapiens)
AKT can phosphorylate RSK (Homo sapiens)
RPS6KB2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBS0 RPS6KB2
Gene Names
RPS6KB2, STK14B
Chain
chain:1-482
Reference Genes
BioGPS Gene:6199 RPS6KB2
COSMIC (genes):RPS6KB2 RPS6KB2
CTD Gene:6199 RPS6KB2
dbSNP Gene:6199 RPS6KB2
ENSEMBL:ENSG00000175634 RPS6KB2
ENSEMBL_homo_sapiens_GENE:ENSG00000175634.15 RPS6KB2
HGNC:10437 RPS6KB2
KEGG Gene (Homo sapiens):6199 RPS6KB2
Monarch:6199 RPS6KB2
NCBI Gene:6199 RPS6KB2
OMIM:608939 RPS6KB2
UCSC:Q9UBS0 RPS6KB2
Reference Transcript
RefSeq:NM_003952.2 RPS6KB2
Other Identifiers
11742837_x_at
11747560_a_at
11747561_s_at
11760951_x_at
16727861
203777_PM_s_at
203777_s_at
3337068
3337069
3337072
3337073
3337074
3337076
3337079
3337081
3337082
3337083
3337084
3337085
3337089
3337091
3337092
3337093
3337095
3337097
3337098
3337099
3337100
3337101
41374_at
6199
7941900
A_14_P114012
A_23_P24318
A_33_P3230488
GE53423
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004711
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0006412
GO:0006468
GO:0007165
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0031929
GO:0036211
GO:0042277
GO:0043226
GO:0043491
GO:0045948
GO:0106310
GO:0140096
HMNXSV003026054
ILMN_1761175
ILMN_2364357
PH_hs_0027748
TC11000691.hg
g4506738_3p_s_at
Participates
as an input of
AKT1 E17K mutant phosphorylates RSK (Homo sapiens)
AKT can phosphorylate RSK (Homo sapiens)
Other forms of this molecule
p-S15,S356-RPS6KB2 [nucleoplasm]
Inferred To
Homologues of RPS6KB2 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of RPS6KB2 [nucleoplasm]
(Drosophila melanogaster)
RPS6KB2 [nucleoplasm]
(Bos taurus)
RPS6KB2 [nucleoplasm]
(Caenorhabditis elegans)
RPS6KB2 [nucleoplasm]
(Canis familiaris)
RPS6KB2 [nucleoplasm]
(Dictyostelium discoideum)
RPS6KB2 [nucleoplasm]
(Drosophila melanogaster)
RPS6KB2 [nucleoplasm]
(Gallus gallus)
RPS6KB2 [nucleoplasm]
(Mus musculus)
RPS6KB2 [nucleoplasm]
(Rattus norvegicus)
RPS6KB2 [nucleoplasm]
(Saccharomyces cerevisiae)
RPS6KB2 [nucleoplasm]
(Schizosaccharomyces pombe)
RPS6KB2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_003943.2
Guide to Pharmacology - Targets
1526
OpenTargets
ENSG00000175634
ZINC - Substances
KS6B2_HUMAN
ZINC target
Q9UBS0
PRO
Q9UBS0
IntEnz
2.7.11.1
HPA
ENSG00000175634-RPS6KB2
GeneCards
Q9UBS0
Ensembl
ENST00000312629
,
ENSG00000175634
,
ENST00000528964
,
ENSP00000432847
,
ENSP00000308413
Pharos - Targets
Q9UBS0
ZINC - Predictions - Purchasable
KS6B2_HUMAN
HMDB Protein
HMDBP11579
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67870 CSNK2B
5
CSNK2B [secretory granule lumen]
(R-HSA-6801319)
CSNK2B [extracellular region]
(R-HSA-6806508)
CSNK2B [ficolin-1-rich granule lumen]
(R-HSA-6801290)
CSNK2B [nucleoplasm]
(R-HSA-6805067)
CSNK2B [cytosol]
(R-HSA-201693)
0.589
3
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