Reactome | p-S63-ATF1 [nucleoplasm]

p-S63-ATF1 [nucleoplasm]

Stable Identifier

R-HSA-199897

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

cyclic-AMP-dependent transcription factor ATF-1(phosphorylated), ATF1_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
        
        p-S63-ATF1 [nucleoplasm] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
        
        p-S63-ATF1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
        
        p-S63-ATF1 [nucleoplasm] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
        
        p-S63-ATF1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
        
        p-S63-ATF1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
        
        p-S63-ATF1 [nucleoplasm] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
        
        p-S63-ATF1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
        
        p-S63-ATF1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
        
        p-S63-ATF1 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        CREB phosphorylation (Homo sapiens)
        
        MSK1 activates ATF1 (Homo sapiens)
        
        p-S63-ATF1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18846 ATF1

Gene Names

ATF1

Chain

chain:1-271

Reference Genes

BioGPS Gene:466 ATF1

COSMIC (genes):ATF1 ATF1

CTD Gene:466 ATF1

dbSNP Gene:466 ATF1

ENSEMBL:ENSG00000123268 ATF1

ENSEMBL_homo_sapiens_GENE:ENSG00000123268.9 ATF1

HGNC:783 ATF1

KEGG Gene (Homo sapiens):466 ATF1

Monarch:466 ATF1

NCBI Gene:466 ATF1

OMIM:123803 ATF1

UCSC:P18846 ATF1

Reference Transcript

Other Identifiers

11743163_at

11743164_x_at

11751694_a_at

1558233_PM_s_at

1558233_s_at

1565269_PM_s_at

1565269_s_at

16751165

222103_PM_at

222103_at

3414696

3414702

3414706

3414709

3414710

3414711

3414712

3414714

3414715

3414716

3414717

3414718

36297_at

466

59352_at

7955425

81232_at

A_23_P105646

A_33_P3294252

GE59807

GO:0000785

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0006260

GO:0006351

GO:0006355

GO:0006357

GO:0010035

GO:0010976

GO:0014070

GO:0014074

GO:0019933

GO:0023052

GO:0030154

GO:0032025

GO:0042802

GO:0043226

GO:0043565

GO:0044877

GO:0045740

GO:0045944

GO:0048856

GO:0050896

GO:0065003

GO:0090575

GO:0140110

GO:1990589

GO:1990590

HMNXSV003049871

Hs.36908.0.S2_3p_at

Hs2.406336.1.A1_3p_s_at

Hs2.406336.3.S1_3p_s_at

ILMN_1801923

PH_hs_0002916

PH_hs_0032288

TC12000397.hg

X55544_at

Participates

as a member of

p-S63 ATF1,p-T69, T71 ATF2 [nucleoplasm] (Homo sapiens)

as an output of

MSK1 activates ATF1 (Homo sapiens)

Other forms of this molecule

ATF1 [nucleoplasm]

Inferred To

phospho-Atf1 [nucleoplasm] (Mus musculus)

phospho-Atf1 [nucleoplasm] (Rattus norvegicus)

phospho-p-S63-ATF1 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S63-ATF1 [nucleoplasm] (Gallus gallus)

phospho-CrebB [nucleoplasm] (Drosophila melanogaster)

phospho-ATF1 [nucleoplasm] (Bos taurus)

phospho-ATF1 [nucleoplasm] (Canis familiaris)

phospho-ATF1 [nucleoplasm] (Sus scrofa)

phospho-atf1 [nucleoplasm] (Danio rerio)

phospho-atf1 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 63

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016874822.1, NP_005162.1, XP_016874823.1, XP_011536688.1, XP_011536689.1, XP_016874821.1

OpenTargets

ENSG00000123268

GeneCards

P18846

ZINC - Substances

ATF1_HUMAN

HPA

ENSG00000123268-ATF1

ZINC target

P18846

Ensembl

ENSG00000123268, ENST00000262053, ENSP00000262053

PRO

P18846

Pharos - Targets

P18846

Orphanet

18482

ZINC - Predictions - Purchasable

ATF1_HUMAN

HMDB Protein

HMDBP08111

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P16220 CREB1			0.697	6
UniProt:P18846 ATF1	2	ATF1 [nucleoplasm] (R-HSA-199900) p-S63-ATF1 [nucleoplasm] (R-HSA-199897)	0.623	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.59	3
UniProt:Q16649 NFIL3	1	NFIL3 [nucleoplasm] (R-HSA-8878899)	0.59	3
UniProt:O95644 NFATC1	3	p-S257-NFATC1 [nucleoplasm] (R-HSA-2025935) p-S257-NFATC1 [cytosol] (R-HSA-2685618) p-12S-NFATC1 [cytosol] (R-HSA-2025953)	0.576	3
UniProt:Q96F63 CCD97			0.527	2
UniProt:Q9NQA5 TRPV5	1	TRPV5 [plasma membrane] (R-HSA-2671930)	0.527	2
UniProt:Q01664 TFAP4			0.527	2
UniProt:Q9Y4X5 ARIH1	1	ARIH1 [cytosol] (R-HSA-1678825)	0.527	2
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.527	2
UniProt:P03259-2			0.524	2
UniProt:P05412 JUN	4	p-S63,S73-JUN [cytosol] (R-HSA-8868682) JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194)	0.499	2