MSK1 activates ATF1

Stable Identifier
R-HSA-199910
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MSK1 activates ATF1
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Cyclic-AMP-dependent transcription factor 1 (ATF1) can be phosphorylated at Serine 63 by MSK1, thus activating it.

Literature References
PubMed ID Title Journal Year
12414794 ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression

Gupta, P, Prywes, R

J. Biol. Chem. 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]

Physical Entity
p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
MSK1 activates ATF1 (Bos taurus)
MSK1 activates ATF1 (Caenorhabditis elegans)
MSK1 activates ATF1 (Canis familiaris)
MSK1 activates ATF1 (Danio rerio)
MSK1 activates ATF1 (Drosophila melanogaster)
MSK1 activates ATF1 (Gallus gallus)
MSK1 activates ATF1 (Mus musculus)
MSK1 activates ATF1 (Rattus norvegicus)
MSK1 activates ATF1 (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-07-13)
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