MAPKAPK2 phosphorylates CREB at Serine 133

Stable Identifier
R-HSA-199917
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MAPKAPK2 phosphorylates CREB at Serine 133
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p38 MAPK activation leads to CREB Serine 133 phosphorylation through the activation of MAPKAP kinase 2 or the closely related MAPKAP kinase 3.

Literature References
PubMed ID Title Journal Year
7551568 Serine 133-phosphorylated CREB induces transcription via a cooperative mechanism that may confer specificity to neurotrophin signals

Bonni, A, Dudek, H, Greenberg, ME, Ginty, DD

Mol. Cell. Neurosci. 1995
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T222,S272-MAPKAPK2 [nucleoplasm]

Physical Entity
p-T222,S272-MAPKAPK2 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
MAPKAPK2 phosphorylates CREB at Serine 133 (Bos taurus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Caenorhabditis elegans)
MAPKAPK2 phosphorylates CREB at Serine 133 (Danio rerio)
MAPKAPK2 phosphorylates CREB at Serine 133 (Drosophila melanogaster)
MAPKAPK2 phosphorylates CREB at Serine 133 (Gallus gallus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Mus musculus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Rattus norvegicus)
MAPKAPK2 phosphorylates CREB at Serine 133 (Sus scrofa)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2007-07-13)
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