Reactome | COPB2 [cytosol]

COPB2 [cytosol]

Stable Identifier

R-HSA-199972

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Coatomer beta' subunit

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        Active ARF recruits coatomer (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        COPI vesicle uncoating (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
      - ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
      - Active ARF recruits coatomer (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
      - COPI vesicle uncoating (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        Active ARF recruits coatomer to the Golgi (Homo sapiens)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)
        
        COPI vesicle uncoating at the ER (Homo sapiens)
        
        coatomer [cytosol] (Homo sapiens)
        
        trimeric coatomer complex [cytosol] (Homo sapiens)
        
        COPB2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35606 COPB2

Gene Names

COPB2

Chain

initiator methionine:, chain:2-906

Reference Genes

BioGPS Gene:9276 COPB2

COSMIC (genes):COPB2 COPB2

CTD Gene:9276 COPB2

dbSNP Gene:9276 COPB2

ENSEMBL:ENSG00000184432 COPB2

HGNC:2232 COPB2

KEGG:hsa:9276 COPB2

Monarch:9276 COPB2

NCBI Gene:9276 COPB2

OMIM:606990 COPB2

UCSC:P35606 COPB2

Reference Transcript

Other Identifiers

11744254_at

11748591_a_at

16959760

201098_PM_at

201098_at

213500_PM_at

213500_at

226256_PM_at

226256_at

2697791

2697793

2697794

2697795

2697796

2697797

2697798

2697799

2697800

2697801

2697802

2697803

2697804

2697805

2697806

2697807

2697808

2697809

2697810

2697812

2697814

2697815

2697816

2697817

2697818

2697819

2697820

2697821

2697822

2697823

2697824

2697825

2697826

2697827

2697828

2697829

2697830

2697831

2697832

2697834

31799_PM_at

31799_at

36677_at

4863505C_3p_s_at

71604_f_at

8091048

9276

A_23_P91891

GE54658

GE59970

GO:0000139

GO:0005198

GO:0005515

GO:0005737

GO:0005789

GO:0005794

GO:0005829

GO:0006886

GO:0006888

GO:0006890

GO:0006891

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030126

GO:0030133

GO:0030663

GO:0031410

GO:0043226

HMNXSV003014232

Hs.107127.3.A1_3p_at

ILMN_1684385

PH_hs_0004365

PH_hs_0039162

RNA147046|p0150_imsncRNA238

TC03001832.hg

TC03003113.hg

X70476_at

g4758031_3p_at

Participates

as a component of

trimeric coatomer complex [cytosol] (Homo sapiens)

Other forms of this molecule

COPB2 [endoplasmic reticulum membrane]

COPB2 [Golgi membrane]

COPB2 [transport vesicle]

Inferred To

copb-2 [cytosol] (Caenorhabditis elegans)

copb2 [cytosol] (Danio rerio)

copb2 [cytosol] (Dictyostelium discoideum)

copb2 [cytosol] (Xenopus tropicalis)

sec27 [cytosol] (Schizosaccharomyces pombe)

beta'COP [cytosol] (Drosophila melanogaster)

SEC27 [cytosol] (Saccharomyces cerevisiae)

COPB2 [cytosol] (Bos taurus)

COPB2 [cytosol] (Canis familiaris)

COPB2 [cytosol] (Gallus gallus)

COPB2 [cytosol] (Plasmodium falciparum)

COPB2 [cytosol] (Sus scrofa)

Copb2 [cytosol] (Mus musculus)

Copb2 [cytosol] (Rattus norvegicus)

Cross References

ENSEMBL

ENSP00000427185, ENST00000333188, ENST00000507777, ENSP00000329419, ENSP00000422469, ENST00000512242, ENSP00000422295, ENST00000514508

OpenTargets

ENSG00000184432

HPA

ENSG00000184432-COPB2

PRO

P35606

Pharos - Targets

P35606

GlyGen

P35606

Orphanet

COPB2

HMDB Protein

HMDBP08330

PDB

8D41, 8D30

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.689	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	10
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	4
UniProt:Q12211 PUS1	1	PUS1 [nucleoplasm] (R-SCE-6790215)	0.556	3
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.499	3
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.462	6