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AKT1S1 [cytosol]
Stable Identifier
R-HSA-200155
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PRAS40, Proline-rich AKT1 substrate 1, AKTS1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by AKT1 E17K in Cancer (Homo sapiens)
AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
AKT1S1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
AKT1S1 [cytosol] (Homo sapiens)
MTOR signalling (Homo sapiens)
AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)
AKT1S1 [cytosol] (Homo sapiens)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
AKT1S1 [cytosol] (Homo sapiens)
Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
AKT1S1 [cytosol] (Homo sapiens)
mTORC1-mediated signalling (Homo sapiens)
Phosphorylation of 4E-BP1 by activated mTORC1 (Homo sapiens)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
AKT1S1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96B36 AKT1S1
Gene Names
AKT1S1, PRAS40
Chain
chain:1-256
Reference Genes
BioGPS Gene:84335 AKT1S1
COSMIC (genes):AKT1S1 AKT1S1
CTD Gene:84335 AKT1S1
dbSNP Gene:84335 AKT1S1
ENSEMBL:ENSG00000204673 AKT1S1
HGNC:28426 AKT1S1
KEGG:hsa:84335 AKT1S1
Monarch:84335 AKT1S1
NCBI Gene:84335 AKT1S1
OMIM:610221 AKT1S1
UCSC:Q96B36 AKT1S1
Reference Transcript
RefSeq:NM_001098633.3 AKT1S1
RefSeq:NM_001098632.2 AKT1S1
RefSeq:NM_001278159.1 AKT1S1
RefSeq:NM_032375.5 AKT1S1
RefSeq:NM_001278160.1 AKT1S1
Other Identifiers
11716720_a_at
11752835_a_at
11754679_a_at
1555821_3p_a_at
1555821_PM_a_at
1555821_a_at
16874419
224982_3p_at
224982_PM_at
224982_at
3868161
3868162
3868163
3868164
3868167
3868168
3868169
3868170
3868171
3868172
3868173
3868174
3868175
3868176
3868177
3868178
3868179
3868180
3868182
3868184
3868185
3868186
48732_at
8038477
84335
89138_at
A_23_P153502
A_24_P944472
A_33_P3222451
A_33_P3344201
GE83409
GO:0004860
GO:0005515
GO:0005654
GO:0005737
GO:0005829
GO:0006469
GO:0030291
GO:0031931
GO:0032007
GO:0032991
GO:0042981
GO:0043523
GO:0045792
GO:0048011
GO:0098772
GO:1904262
HMNXSV003010774
Hs.94814.0.S1_3p_s_at
Hs2.94814.3.S1_3p_s_at
ILMN_1726906
PH_hs_0023196
TC19001728.hg
Participates
as an input of
AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
AKT1S1 (PRAS40) binds mTORC1 (Homo sapiens)
AKT phosphorylates AKT1S1 (PRAS40) (Homo sapiens)
as a component of
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Homo sapiens)
Other forms of this molecule
p-S183,T246-AKT1S1 [cytosol]
p-T246-AKT1S1 [cytosol]
AKT1S1 [nucleoplasm]
Inferred To
akt1s1 [cytosol]
(Xenopus tropicalis)
PRAS40 [cytosol]
(Drosophila melanogaster)
AKT1S1 [cytosol]
(Bos taurus)
AKT1S1 [cytosol]
(Canis familiaris)
AKT1S1 [cytosol]
(Sus scrofa)
Ghost homologue of AKT1S1 [cytosol]
(Caenorhabditis elegans)
Ghost homologue of AKT1S1 [cytosol]
(Danio rerio)
Ghost homologue of AKT1S1 [cytosol]
(Dictyostelium discoideum)
Ghost homologue of AKT1S1 [cytosol]
(Gallus gallus)
Akt1s1 [cytosol]
(Mus musculus)
Akt1s1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001092102.1
,
NP_001265088.1
,
NP_001265089.1
,
NP_115751.3
,
NP_001092103.1
OpenTargets
ENSG00000204673
ENSEMBL
ENSP00000375710
,
ENSP00000375709
,
ENSP00000375707
,
ENSP00000375708
,
ENST00000391831
,
ENST00000344175
,
ENST00000391832
,
ENST00000391833
,
ENST00000391834
,
ENST00000391835
,
ENSP00000375711
,
ENSP00000341698
HPA
ENSG00000204673-AKT1S1
ZINC - Substances
AKTS1_HUMAN
ZINC target
Q96B36
PRO
Q96B36
Pharos - Targets
Q96B36
GlyGen
Q96B36
ZINC - Predictions - Purchasable
AKTS1_HUMAN
PDB
5WBU
,
5WBY
,
6SB0
,
5WBL
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.837
7
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.725
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.725
4
UniProt:P42345 MTOR
2
MTOR [cytosol]
(R-HSA-165662)
MTOR [nucleoplasm]
(R-HSA-5083674)
0.669
3
UniProt:Q8N122 RPTOR
3
p-S722,S792-RPTOR [cytosol]
(R-HSA-3132767)
RPTOR [cytosol]
(R-HSA-3006727)
RPTOR [nucleoplasm]
(R-HSA-5083664)
0.669
5
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
2
UniProt:P29311 BMH1
1
BMH1 [cytosol]
(R-SCE-1454714)
0.527
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.527
2
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