Reactome | PRKAA2 [cytosol]

PRKAA2 [cytosol]

Stable Identifier

R-HSA-200405

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMPK alpha2 (inactive)

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Locations in the PathwayBrowser for interactor UniProt:A2BDD9 A2BDD9

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External Reference Information

External Reference

UniProt:P54646 PRKAA2

Gene Names

PRKAA2, AMPK, AMPK2

Chain

chain:1-552

Reference Genes

BioGPS Gene:5563 PRKAA2

COSMIC (genes):PRKAA2 PRKAA2

CTD Gene:5563 PRKAA2

dbSNP Gene:5563 PRKAA2

ENSEMBL:ENSG00000162409 PRKAA2

HGNC:9377 PRKAA2

KEGG:hsa:5563 PRKAA2

Monarch:5563 PRKAA2

NCBI Gene:5563 PRKAA2

OMIM:600497 PRKAA2

UCSC:P54646 PRKAA2

Reference Transcript

RefSeq:NM_006252.3 PRKAA2

Other Identifiers

11729364_at

11729365_at

11729366_at

11729367_at

16665182

186_at

207709_PM_at

207709_at

227892_PM_at

227892_at

2337719

2337720

2337721

2337725

2337728

2337729

2337730

2337732

2337733

2337734

2337735

2337736

2337737

2337738

2337739

2337741

2337743

2337744

2337745

2337747

238441_PM_at

238441_at

238489_PM_at

238489_at

240349_PM_at

240349_at

41929_at

54326_at

5563

57820_r_at

7901720

82810_at

90088_at

A_23_P60811

A_32_P94160

GE58883

GE813527

GO:0003682

GO:0003824

GO:0004672

GO:0004674

GO:0004679

GO:0004712

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0006325

GO:0006338

GO:0006468

GO:0006629

GO:0006633

GO:0006695

GO:0006914

GO:0007165

GO:0008610

GO:0010468

GO:0010494

GO:0010508

GO:0010629

GO:0014850

GO:0016055

GO:0016239

GO:0016241

GO:0016607

GO:0016740

GO:0030424

GO:0030425

GO:0031588

GO:0031669

GO:0032007

GO:0034599

GO:0042149

GO:0042593

GO:0042752

GO:0043025

GO:0043066

GO:0043226

GO:0045821

GO:0046872

GO:0047322

GO:0048511

GO:0055089

GO:0062028

GO:0070507

GO:0071277

GO:0071333

GO:0071380

GO:0071466

GO:0097009

GO:0106310

GO:0140096

GO:0140823

GO:1903829

GO:1903944

GO:1904262

GO:1904428

GO:1905691

GO:1990044

GO:2000758

HMNXSV003046296

Hs.127301.0.A1_3p_at

Hs.139293.0.S1_3p_at

Hs.145568.0.A1_3p_at

Hs.86379.0.A1_3p_at

Hs.86379.0.A1_3p_x_at

ILMN_1668778

PH_hs_0020627

PH_hs_0023278

TC01000685.hg

TC01004414.hg

U06454_at

g5453965_3p_at

Participates

as a member of

AMPK alpha [cytosol] (Homo sapiens)

as an input of

PLINs:HSPA8 binds PRKAA2 (Homo sapiens)

as a component of

as an output of

PRKAA2 dissociate from p-PLINs:HSPA8 (Homo sapiens)

Other forms of this molecule

p-T172-PRKAA2 [cytosol]

p-T172-PRKAA2 [nucleoplasm]

PRKAA2 [nucleoplasm]

Inferred To

Prkaa2 [cytosol] (Mus musculus)

PRKAA2 [cytosol] (Bos taurus)

PRKAA2 [cytosol] (Caenorhabditis elegans)

PRKAA2 [cytosol] (Canis familiaris)

PRKAA2 [cytosol] (Dictyostelium discoideum)

PRKAA2 [cytosol] (Drosophila melanogaster)

PRKAA2 [cytosol] (Gallus gallus)

PRKAA2 [cytosol] (Rattus norvegicus)

PRKAA2 [cytosol] (Saccharomyces cerevisiae)

PRKAA2 [cytosol] (Schizosaccharomyces pombe)

PRKAA2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_006243.2

Guide to Pharmacology - Targets

1542

OpenTargets

ENSG00000162409

ENSEMBL

ENSP00000360290, ENST00000371244

HPA

ENSG00000162409-PRKAA2

ZINC target

P54646

PRO

P54646

Pharos - Targets

P54646

GlyGen

P54646

HMDB Protein

HMDBP01902

PDB

4CFE, 2YZA, 3AQV, 4CFF, 4ZHX, 6B2E, 2H6D, 6BX6, 2LTU, 5ISO, 6B1U, 7MYJ, 5EZV

Interactors (115)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54619 PRKAG1	2	PRKAG1 [cytosol] (R-HSA-380946) PRKAG1 [nucleoplasm] (R-HSA-2151202)	0.933	14
UniProt:O43741 PRKAB2	2	PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [nucleoplasm] (R-HSA-164096)	0.933	17
UniProt:Q9Y478 PRKAB1	2	PRKAB1 [cytosol] (R-HSA-380968) PRKAB1 [nucleoplasm] (R-HSA-2151199)	0.845	10
UniProt:Q04864-2 REL			0.666	4
UniProt:Q9BVG8 KIFC3			0.666	4
UniProt:Q9NYB9 ABI2	2	p-4S-ABI2 [cytosol] (R-HSA-2029003) ABI2 [cytosol] (R-HSA-1671647)	0.666	5
UniProt:Q9NPC3 CIP1			0.666	4
UniProt:Q5JR59-3 MTUS2			0.666	4
UniProt:Q9UGI9 PRKAG3	2	PRKAG3 [nucleoplasm] (R-HSA-2151211) PRKAG3 [cytosol] (R-HSA-381839)	0.643	4
UniProt:Q9UGJ0 PRKAG2	2	PRKAG2 [nucleoplasm] (R-HSA-164130) PRKAG2 [cytosol] (R-HSA-200419)	0.643	6
UniProt:Q9P246 STIM2			0.643	3
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.564	2
UniProt:Q6NT76 HMBX1			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:Q5T7B8-2 KIF24			0.556	3
UniProt:Q9Y605 MOFA1			0.556	3
UniProt:Q9P1Z2 CACO1			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q7Z5V6-2 SAXO4			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q6FG41 Q6FG41			0.556	3
UniProt:Q93062 RBPMS			0.556	3
UniProt:Q53EP0-3 FNDC3B			0.556	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.556	3
UniProt:Q96BR9 ZBT8A			0.556	3
UniProt:Q9UK41-2 VPS28			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q8IZP0-5 ABI1			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:P41219 PERI			0.556	3
UniProt:Q86T90 K1328			0.556	3
UniProt:Q5T686 AVPI1			0.556	3
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q5JUK2 SOLH1			0.556	3
UniProt:Q9NQM4 DAAF6			0.556	3
IntAct:EBI-22432104 CCSB ORF ID			0.556	3
UniProt:Q86Y26 NUTM1			0.556	3
UniProt:Q9Y3Q8 T22D4			0.556	3
UniProt:Q96B67 ARRD3			0.556	3
UniProt:O75638-2 CTAG2			0.556	3
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.556	3
UniProt:Q9NYG5-2 ANAPC11			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q92624 APBP2			0.556	3
UniProt:Q9Y6C2-2 EMILIN1			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:O95208-2 EPN2			0.556	3
UniProt:P0C7W6 CC172			0.556	3
UniProt:Q7L273 KCTD9			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q92997 DVL3	4	pp-DVL3 [cytosol] (R-HSA-3772400) p-DVL3 [cytosol] (R-HSA-201680) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:Q96L93-6 KIF16B			0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.556	3
UniProt:P12524-2 P125242			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.556	3
UniProt:Q6PF18 MORN3			0.556	3
UniProt:Q9H0C1 ZMY12			0.556	3
UniProt:Q15477 SKIC2	1	SKIV2L [cytosol] (R-HSA-391294)	0.556	3
UniProt:Q3MJ62 ZSC23			0.556	3
UniProt:P08779 KRT16	1	KRT16 [cytosol] (R-HSA-201581)	0.556	3
UniProt:Q9UDV6 ZNF212	1	ZNF212 [nucleoplasm] (R-HSA-1027348)	0.556	3
UniProt:Q8N684-3 CPSF7			0.556	3
UniProt:Q15233-2 NONO			0.556	3
UniProt:Q96JM7 LMBL3			0.556	3
UniProt:Q495M9 USH1G	1	USH1G [cytosol] (R-HSA-9658869)	0.556	3
UniProt:Q96CG3 TIFA	2	TIFA [cytosol] (R-HSA-451582) p-T9-TIFA [cytosol] (R-HSA-9645512)	0.556	3
UniProt:Q8NF99 ZN397			0.556	3
UniProt:P80188 LCN2	2	LCN2 [extracellular region] (R-HSA-5215934) LCN2 [specific granule lumen] (R-HSA-6799614)	0.556	3
UniProt:O75420 GGYF1			0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q494U1-3 PLEKHN1			0.556	3
UniProt:Q15645 PCH2			0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:Q01850 CDR2			0.556	3
UniProt:Q96F24 NRBF2			0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.556	3
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.556	3
UniProt:Q9H6Q3 SLA2	1	SLA2 [cytosol] (R-HSA-9706161)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.556	3
UniProt:Q9ULX6 AKAP8L	1	AKAP8L [nucleoplasm] (R-HSA-9821364)	0.556	3
UniProt:P08151 GLI1	9	ub-GLI1 [cytosol] (R-HSA-5635833) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) pS-GLI1 [ciliary base] (R-HSA-5610497) GLI1 [cytosol] (R-HSA-445457) p-GLI1 [ciliary tip] (R-HSA-5635040) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [nucleoplasm] (R-HSA-5635042) GLI1 [ciliary base] (R-HSA-5610357) GLI1 [ciliary tip] (R-HSA-5610360)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:O14627 CDX4			0.556	3
UniProt:Q9UJW9 SRTD3			0.556	3
UniProt:Q86YV0 RASAL3	1	RASAL3 [cytosol] (R-HSA-5658226)	0.556	3
UniProt:Q9Y6N9-4 USH1C			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:O43609 SPRY1	3	p-Y53-SPRY1 [cytosol] (R-HSA-182933) SPRY1 [plasma membrane] (R-HSA-182944) SPRY1 [cytosol] (R-HSA-182908)	0.556	3
UniProt:Q00587-2 CDC42EP1			0.556	3
UniProt:Q6ZMT1 STAC2			0.556	3
UniProt:A2BDD9 A2BDD9			0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:Q8HWS3 RFX6	1	RFX6 [nucleoplasm] (R-HSA-8931801)	0.556	3
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.556	3
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.536	3
UniProt:Q13131 PRKAA1	3	p-T183-PRKAA1 [cytosol] (R-HSA-380964) PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.527	3
UniProt:Q9UI47 CTNA3			0.527	2
UniProt:Q96RR4 CAMKK2	4	p-CAMKK2 [nucleoplasm] (R-HSA-9618968) CAMKK2 [nucleoplasm] (R-HSA-5336483) p-CAMKK2 [cytosol] (R-HSA-9619358) CAMKK2 [cytosol] (R-HSA-9619231)	0.527	2

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