Reactome | MTHFD1 [cytosol]

MTHFD1 [cytosol]

Stable Identifier

R-HSA-200641

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P11586 MTHFD1

Gene Names

MTHFD1, MTHFC, MTHFD

Chain

chain:1-935, initiator methionine:, chain:2-935

Reference Genes

BioGPS Gene:4522 MTHFD1

COSMIC (genes):MTHFD1 MTHFD1

CTD Gene:4522 MTHFD1

dbSNP Gene:4522 MTHFD1

ENSEMBL:ENSG00000100714 MTHFD1

ENSEMBL_homo_sapiens_GENE:ENSG00000100714.18 MTHFD1

HGNC:7432 MTHFD1

KEGG Gene (Homo sapiens):4522 MTHFD1

Monarch:4522 MTHFD1

NCBI Gene:4522 MTHFD1

OMIM:172460 MTHFD1

UCSC:P11586 MTHFD1

Reference Transcript

RefSeq:NM_005956.3 MTHFD1

Other Identifiers

11716667_a_at

16785316

202309_PM_at

202309_at

3540010

3540011

3540013

3540019

3540020

3540021

3540022

3540023

3540024

3540025

3540026

3540027

3540029

3540030

3540031

3540032

3540033

3540034

3540036

3540038

3540040

3540042

3540043

3540045

3540046

3540047

3540048

3540052

3540053

3540055

3540059

3540060

3540061

4010277

4010285

4010286

4010287

43403_at

4522

673_at

674_g_at

7975045

A_23_P117494

GO:0000166

GO:0001780

GO:0001843

GO:0002376

GO:0003824

GO:0004329

GO:0004477

GO:0004486

GO:0004487

GO:0004488

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005737

GO:0005739

GO:0005829

GO:0006164

GO:0006520

GO:0006555

GO:0006575

GO:0006730

GO:0006790

GO:0007507

GO:0008152

GO:0009069

GO:0009070

GO:0009086

GO:0009152

GO:0009257

GO:0016020

GO:0016491

GO:0016787

GO:0016874

GO:0019346

GO:0035999

GO:0043226

GO:0048702

GO:0048703

GO:0048856

GO:0055086

GO:0061053

GO:0070062

GO:1901135

HMNXSV003024349

J04031_at

PH_hs_0025456

TC14000388.hg

g13699867_3p_at

Participates

as a component of

MTHFD1 dimer [cytosol] (Homo sapiens)

Inferred To

dao-3 [cytosol] (Caenorhabditis elegans)

mthfd1 [cytosol] (Xenopus tropicalis)

mthfd1a [cytosol] (Danio rerio)

MTHFD1 [cytosol] (Bos taurus)

MTHFD1 [cytosol] (Canis familiaris)

MTHFD1 [cytosol] (Dictyostelium discoideum)

MTHFD1 [cytosol] (Drosophila melanogaster)

MTHFD1 [cytosol] (Gallus gallus)

MTHFD1 [cytosol] (Mus musculus)

MTHFD1 [cytosol] (Plasmodium falciparum)

MTHFD1 [cytosol] (Rattus norvegicus)

MTHFD1 [cytosol] (Saccharomyces cerevisiae)

MTHFD1 [cytosol] (Schizosaccharomyces pombe)

MTHFD1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005947.3

OpenTargets

ENSG00000100714

HPA

ENSG00000100714-MTHFD1

GeneCards

P11586

ZINC target

P11586

Ensembl

ENST00000651537, ENSP00000498511, ENSG00000100714, ENSP00000498336, ENST00000652337

PRO

P11586

Pharos - Targets

P11586

Orphanet

16813

PDB

6ECQ, 1DIA, 6ECR, 1DIG, 6ECP, 1A4I, 1DIB

HMDB Protein

HMDBP00923

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	18

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