SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG

Stable Identifier
R-HSA-200735
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine
ReviewStatus
5/5
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SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG
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Cytosolic serine hydroxymethyltransferase catalyzes the reversible reaction of tetrahydrofolate polyglutamate (THF polyglutamate) and serine to form 5,10-methyleneTHF polyglutamate and glycine. The active form of the enzyme is a tetramer (Renwick et al. 1998). In the body, this reaction is a major source of 5,10-methyleneTHF, which in turn is a critical precursor in the synthesis of dTMP.
Literature References
PubMed ID Title Journal Year
9753690 The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy

Baumann, U, Snell, K, Renwick, SB

Structure 1998
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Catalyst Activity

aldehyde-lyase activity of SHMT1 tetramer [cytosol]

Physical Entity
SHMT1 tetramer [cytosol] (Homo sapiens)
Activity
aldehyde-lyase activity (GO:0016832)
Orthologous Events
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Bos taurus)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Caenorhabditis elegans)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Canis familiaris)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Danio rerio)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Dictyostelium discoideum)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Drosophila melanogaster)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Gallus gallus)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Mus musculus)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Plasmodium falciparum)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Rattus norvegicus)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Sus scrofa)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Xenopus tropicalis)
Created
D'Eustachio, P  (2007-07-24)
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