Reactome | ARF1 [cytosol]

ARF1 [cytosol]

Stable Identifier

R-HSA-200826

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Arf1

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Locations in the PathwayBrowser for interactor UniProt:P60880 SNAP25

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
        
        Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
        
        Nef Mediated CD4 Down-regulation (Homo sapiens)
        
        Formation of a Nef:ARF1:CD4 complex (Homo sapiens)
        
        ARF1 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of ADP-ribosylation factor 1 (Homo sapiens)
        
        ARF1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P84077 ARF1

Gene Names

ARF1

Chain

initiator methionine:, chain:2-181

Reference Genes

BioGPS Gene:375 ARF1

COSMIC (genes):ARF1 ARF1

CTD Gene:375 ARF1

dbSNP Gene:375 ARF1

ENSEMBL:ENSG00000143761 ARF1

HGNC:652 ARF1

KEGG:hsa:375 ARF1

Monarch:375 ARF1

NCBI Gene:375 ARF1

OMIM:103180 ARF1

UCSC:P84077 ARF1

Reference Transcript

Other Identifiers

11719759_s_at

16656669

16656691

16656693

16656717

16656719

16678303

16678320

18670609

18670610

18670611

18670612

18670613

18670614

18670615

18670616

18670617

18670618

18670619

200065_PM_s_at

200065_s_at

208750_PM_s_at

208750_s_at

2383733

2383734

2383735

2383736

2383737

2383738

2383743

2383744

2383746

2383747

2383748

2383754

2383755

2383756

2383757

2383758

2383759

2383760

2383761

2383762

2383763

2383764

2383765

2383766

2383767

2383768

2383769

244504_3p_x_at

244504_PM_x_at

244504_x_at

33987_at

375

7892830

7893568

7893592

7893609

7894011

7894290

7894336

7894413

7894767

7894808

7895084

7895110

7895484

7895597

7895881

7896158

7896375

7896586

7896657

7910229

A_23_P201086

A_24_P190894

A_24_P259490

GE63168

GO:0000139

GO:0000287

GO:0002090

GO:0003723

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005794

GO:0005829

GO:0005886

GO:0005925

GO:0006878

GO:0006886

GO:0012505

GO:0014069

GO:0015031

GO:0016020

GO:0016192

GO:0016787

GO:0019904

GO:0030017

GO:0031252

GO:0032991

GO:0034315

GO:0043005

GO:0043226

GO:0045202

GO:0060292

GO:0061024

GO:0070062

GO:0097061

GO:0098586

GO:1990386

HMNXSV003032236

Hs.282187.0.A1_3p_at

Hs.282187.0.A1_3p_x_at

Hs.74571.0.A1_3p_a_at

ILMN_1661458

ILMN_1802203

ILMN_2330948

M84332_at

PH_hs_0023485

TC01001884.hg

g3360490_3p_a_at

Participates

as a component of

as an output of

Expression of ADP-ribosylation factor 1 (Homo sapiens)

as an input of

Formation of a Nef:ARF1:CD4 complex (Homo sapiens)

as a candidate of

ARFs [cytosol] (Homo sapiens)

Other forms of this molecule

ARF1 [Golgi membrane]

Inferred To

arrA [cytosol] (Dictyostelium discoideum)

arrE [cytosol] (Dictyostelium discoideum)

arrD [cytosol] (Dictyostelium discoideum)

arf5 [cytosol] (Xenopus tropicalis)

ARF1 [cytosol] (Bos taurus)

ARF1 [cytosol] (Caenorhabditis elegans)

ARF1 [cytosol] (Canis familiaris)

ARF1 [cytosol] (Dictyostelium discoideum)

ARF1 [cytosol] (Drosophila melanogaster)

ARF1 [cytosol] (Gallus gallus)

ARF1 [cytosol] (Mus musculus)

ARF1 [cytosol] (Plasmodium falciparum)

ARF1 [cytosol] (Rattus norvegicus)

ARF1 [cytosol] (Saccharomyces cerevisiae)

ARF1 [cytosol] (Schizosaccharomyces pombe)

ARF1 [cytosol] (Sus scrofa)

arf1 [cytosol] (Danio rerio)

arrB [cytosol] (Dictyostelium discoideum)

Homologues of ARF1 [cytosol] (Caenorhabditis elegans)

Homologues of ARF1 [cytosol] (Dictyostelium discoideum)

Homologues of ARF1 [cytosol] (Plasmodium falciparum)

Homologues of ARF1 [cytosol] (Saccharomyces cerevisiae)

arrC [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001019399.1, NP_001019397.1, NP_001019398.1, NP_001649.1

OpenTargets

ENSG00000143761

ENSEMBL

ENST00000478336, ENSG00000143761, ENSP00000272102, ENST00000272102, ENST00000478424, ENSP00000514657, ENST00000470558, ENSP00000514653, ENSP00000514654

ZINC - Substances

ARF1_HUMAN

ZINC target

P84077

PRO

P84077

GlyGen

P84077

PDB

7DN8, 7MGE, 7DN9, 8SDW, 1U81, 3O47, 6CM9, 6DFF, 8D4C, 7UX3, 8D4D, 8D4F, 7R4H, 6FAE, 8D4E, 8D4G, 1HUR, 1RE0, 4HMY, 8D9W, 8D9U, 6D83, 8D9R, 6CRI, 8D9S, 6D84

HPA

ENSG00000143761-ARF1

GeneCards

ARF1

Pharos - Targets

P84077

Orphanet

ARF1

ZINC - Predictions - Purchasable

ARF1_HUMAN

HMDB Protein

HMDBP01962

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99418 CYTH2	2	CYTH2 [cytosol] (R-HSA-8847831) CYTH2 [Golgi membrane] (R-HSA-8847829)	0.722	5
UniProt:P53365 ARFIP2	1	ARFIP2 [cytosol] (R-HSA-6813848)	0.621	3
UniProt:P53367 ARFP1			0.524	2
UniProt:P60880 SNAP25	7	SNAP25 [plasma membrane] (R-HSA-2029017) SNAP25 [tertiary granule membrane] (R-HSA-6806142) SNAP25 [specific granule membrane] (R-HSA-6806154) SNAP25(199-206) [cytosol] (R-HSA-5244501) SNAP25(1-198) [plasma membrane] (R-HSA-3004550) SNAP25(198-206) [cytosol] (R-HSA-5244499) SNAP25(1-197) [plasma membrane] (R-HSA-3004546)	0.512	5
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2