Reactome | ELMO1 [cytosol]

ELMO1 [cytosol]

Stable Identifier

R-HSA-200932

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Engulfment and cell motility protein 1, ELM1_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
      - Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
      - Phosphorylated PXN recruits the CRK complex (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - DOCK180:ELMO binds CRK (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
        
        DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92556 ELMO1

Gene Names

ELMO1, KIAA0281

Chain

chain:1-727

Reference Genes

BioGPS Gene:9844 ELMO1

COSMIC (genes):ELMO1 ELMO1

CTD Gene:9844 ELMO1

dbSNP Gene:9844 ELMO1

ENSEMBL:ENSG00000155849 ELMO1

ENSEMBL_homo_sapiens_GENE:ENSG00000155849.16 ELMO1

HGNC:16286 ELMO1

KEGG Gene (Homo sapiens):9844 ELMO1

Monarch:9844 ELMO1

NCBI Gene:9844 ELMO1

OMIM:606420 ELMO1

UCSC:Q92556 ELMO1

Reference Transcript

Other Identifiers

11729610_a_at

11730851_a_at

11730852_x_at

11749475_a_at

17056740

204513_PM_s_at

204513_s_at

3046196

3046198

3046199

3046202

3046209

3046213

3046220

3046224

3046251

3046254

3046256

3046289

3046302

3046323

3046324

3046327

3046330

3046331

3046333

3046336

3046340

3046343

3046354

3046358

3046366

3046367

3046378

3046379

35633_at

7896688

7896704

8139057

8180411

9844

A_23_P122937

A_24_P72420

D87457_at

GE57409

GE864558

GO:0005085

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006909

GO:0006911

GO:0006915

GO:0007010

GO:0007015

GO:0012501

GO:0016020

GO:0016192

GO:0016601

GO:0017124

GO:0023052

GO:0030029

GO:0030036

GO:0032045

GO:0048870

GO:0061024

GO:0098772

HMNXSV003039286

ILMN_1663627

ILMN_1740231

ILMN_1784320

ILMN_2379527

PH_hs_0025985

TC07001288.hg

TC07002893.hg

g7662037_3p_a_at

p33716

Participates

as a component of

DOCK2:ELMO1:RAC1:Nef Complex [cytosol] (Homo sapiens)

as an input of

Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)

as a member of

ELMO1,ELMO2 [cytosol] (Homo sapiens)

Inferred To

elmoF [cytosol] (Dictyostelium discoideum)

Ced-12 [cytosol] (Drosophila melanogaster)

elmo1 [cytosol] (Xenopus tropicalis)

Elmo1 [cytosol] (Mus musculus)

Elmo1 [cytosol] (Rattus norvegicus)

Homologues of ELMO1 [cytosol] (Dictyostelium discoideum)

elmoE [cytosol] (Dictyostelium discoideum)

ELMO1 [cytosol] (Bos taurus)

ELMO1 [cytosol] (Canis familiaris)

ELMO1 [cytosol] (Gallus gallus)

ELMO1 [cytosol] (Sus scrofa)

LMO1 [cytosol] (Saccharomyces cerevisiae)

ced-12 [cytosol] (Caenorhabditis elegans)

elmoC [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

XP_011513956.1, XP_016868328.1, NP_569709.1, NP_055615.8, XP_006715868.1, NP_001034548.1, NP_001193409.1, NP_001193411.1, XP_016868327.1, XP_005249976.1

OpenTargets

ENSG00000155849

GeneCards

Q92556

HPA

ENSG00000155849-ELMO1

Ensembl

ENST00000442504, ENST00000310758, ENSP00000312185, ENSP00000379360, ENST00000396045, ENST00000448602, ENSP00000406952, ENST00000396040, ENSP00000394458, ENSG00000155849, ENSP00000379355

PRO

Q92556

Pharos - Targets

Q92556

HMDB Protein

HMDBP11495

PDB

6TGC, 6JPP, 2RQR, 7Y4A, 3A98, 6TGB, 2VSZ, 7DPA

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14185 DOCK1	1	DOCK1 [cytosol] (R-HSA-372654)	0.937	20
UniProt:Q8TD17 ZNF398	1	ZNF398 [nucleoplasm] (R-HSA-1247512)	0.801	6
UniProt:Q8IZD9 DOCK3	1	DOCK3 [cytosol] (R-HSA-1012973)	0.643	4
UniProt:P84095 RHOG	4	RHOG [secretory granule membrane] (R-HSA-6804965) RHOG [endoplasmic reticulum membrane] (R-HSA-5672084) RHOG [cytosol] (R-HSA-194909) RHOG [plasma membrane] (R-HSA-194880)	0.623	4
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.564	4
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:P07355 ANXA2	6	ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [external side of plasma membrane] (R-HSA-5336164) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) p-S26-ANXA2 [cytosol] (R-HSA-9865163) ANXA2 [extracellular region] (R-HSA-6806242) ANXA2 [azurophil granule lumen] (R-HSA-6798766)	0.537	3
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	2
UniProt:Q96JJ3 ELMO2	1	ELMO2 [cytosol] (R-HSA-372642)	0.527	3
UniProt:P27482 CALL3			0.527	2
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.524	4