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DOCK2 [cytosol]
Stable Identifier
R-HSA-200938
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Dedicator of cytokinesis protein 2, DOC2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9BWT7 CAR10
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
Host Interactions of HIV factors (Homo sapiens)
The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
Nef and signal transduction (Homo sapiens)
Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)
DOCK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92608 DOCK2
Gene Names
DOCK2, KIAA0209
Chain
chain:1-1830
Reference Genes
BioGPS Gene:1794 DOCK2
COSMIC (genes):DOCK2 DOCK2
CTD Gene:1794 DOCK2
dbSNP Gene:1794 DOCK2
ENSEMBL:ENSG00000134516 DOCK2
ENSEMBL_homo_sapiens_GENE:ENSG00000134516.20 DOCK2
HGNC:2988 DOCK2
KEGG Gene (Homo sapiens):1794 DOCK2
Monarch:1794 DOCK2
NCBI Gene:1794 DOCK2
OMIM:603122 DOCK2
UCSC:Q92608 DOCK2
Reference Transcript
RefSeq:NM_004946.2 DOCK2
Other Identifiers
11723871_a_at
16992122
1794
213160_PM_at
213160_at
2840037
2840038
2840043
2840044
2840047
2840049
2840050
2840052
2840053
2840054
2840056
2840057
2840058
2840059
2840061
2840062
2840067
2840070
2840072
2840073
2840075
2840076
2840077
2840078
2840079
2840085
2840086
2840087
2840088
2840100
2840109
2840110
2840149
2840150
2840151
2840154
2840155
2840156
2840157
2840162
2840164
2840166
2840168
2840169
2840170
2840171
2840172
2840174
2840176
2840178
2840179
2840180
2840182
2840183
2840184
2840186
2840188
2840189
2840190
2840191
32704_at
8109843
A_14_P128607
A_24_P263653
A_24_P408704
D86964_at
GE517478
GO:0001766
GO:0001768
GO:0001771
GO:0002277
GO:0002376
GO:0005085
GO:0005096
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006935
GO:0007010
GO:0007163
GO:0007264
GO:0007520
GO:0012505
GO:0016020
GO:0016192
GO:0016477
GO:0023052
GO:0030036
GO:0030154
GO:0031267
GO:0031410
GO:0035580
GO:0042098
GO:0042110
GO:0042608
GO:0043226
GO:0044351
GO:0045059
GO:0045060
GO:0046631
GO:0046633
GO:0048856
GO:0048870
GO:0050766
GO:0051056
GO:0061024
GO:0070062
GO:0098772
HMNXSV003005217
HMNXSV003035525
Hs.17211.0.S1_3p_at
ILMN_1799725
PH_hs_0001559
TC05000929.hg
Participates
as a candidate of
RHOA GEFs [cytosol] (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
DOCK-GEFs [cytosol] (Homo sapiens)
as a member of
RAC2 GEFs [cytosol] (Homo sapiens)
RHOG plasma membrane effectors [cytosol] (Homo sapiens)
as a component of
DOCK2:ELMO1:RAC1:Nef Complex [cytosol] (Homo sapiens)
as an input of
Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)
Other forms of this molecule
DOCK2 [specific granule lumen]
DOCK2 [extracellular region]
Inferred To
docA [cytosol]
(Dictyostelium discoideum)
Homologues of DOCK2 [cytosol]
(Dictyostelium discoideum)
docB [cytosol]
(Dictyostelium discoideum)
docD [cytosol]
(Dictyostelium discoideum)
docC [cytosol]
(Dictyostelium discoideum)
dock2 [cytosol]
(Xenopus tropicalis)
ced-5 [cytosol]
(Caenorhabditis elegans)
DCK1 [cytosol]
(Saccharomyces cerevisiae)
Dock2 [cytosol]
(Mus musculus)
Dock2 [cytosol]
(Rattus norvegicus)
DOCK2 [cytosol]
(Bos taurus)
DOCK2 [cytosol]
(Canis familiaris)
DOCK2 [cytosol]
(Gallus gallus)
DOCK2 [cytosol]
(Sus scrofa)
mbc [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_004937.1
OpenTargets
ENSG00000134516
HPA
ENSG00000134516-DOCK2
GeneCards
Q92608
Ensembl
ENST00000520908
,
ENSP00000429283
,
ENSG00000134516
PRO
Q92608
Pharos - Targets
Q92608
Orphanet
23730
HMDB Protein
HMDBP08353
PDB
3B13
,
6TGC
,
2RQR
,
6TGB
,
3A98
,
2YIN
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.718
6
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.718
6
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.718
6
UniProt:Q99750 MDFI
0.718
8
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.718
6
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.589
3
IntAct:EBI-7355238 Q85737
0.558
5
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
UniProt:Q6N022 TEN4
0.556
3
UniProt:Q9BWT7 CAR10
0.556
3
UniProt:Q9BYR6 KRTAP3-3
1
KRTAP3-3 [cytosol]
(R-HSA-6809859)
0.556
3
UniProt:Q92824-2 PCSK5
0.556
3
UniProt:Q9BYR5 KRTAP4-2
1
KRTAP4-2 [cytosol]
(R-HSA-6809948)
0.556
3
UniProt:P60328 KRTAP12-3
1
KRTAP12-3 [cytosol]
(R-HSA-6810284)
0.556
3
UniProt:Q9BYP8 KRTAP17-1
1
KRTAP17-1 [cytosol]
(R-HSA-6809980)
0.556
3
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.556
6
UniProt:Q9BYR8 KRTAP3-1
1
KRTAP3-1 [cytosol]
(R-HSA-6809868)
0.556
3
IntAct:EBI-10173330 386677
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
5
UniProt:Q13137 CACO2
0.556
3
UniProt:P61978-2 HNRNPK
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:O95273 CCDB1
0.556
3
IntAct:EBI-10171679 386682
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
1
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
0.556
3
UniProt:P36406 TRI23
0.556
3
UniProt:Q6L8G8 KRTAP5-7
1
KRTAP5-7 [cytosol]
(R-HSA-6810273)
0.556
3
UniProt:O15162 PLS1
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:Q9BYQ2 KRTAP9-4
1
KRTAP9-4 [cytosol]
(R-HSA-6809971)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
3
UniProt:O75525 KHDRBS3
2
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
0.556
3
UniProt:P22735 TGM1
3
TGM1 [cytosol]
(R-HSA-6813756)
TGM1 [cornified envelope]
(R-HSA-8847706)
TGM1 [plasma membrane]
(R-HSA-6813757)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q9BYQ4 KRTAP9-2
1
KRTAP9-2 [cytosol]
(R-HSA-6809965)
0.556
3
UniProt:Q9BYQ3 KRTAP9-3
1
KRTAP9-3 [cytosol]
(R-HSA-6809954)
0.556
3
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