Reactome | DOCK2 [cytosol]

DOCK2 [cytosol]

Stable Identifier

R-HSA-200938

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dedicator of cytokinesis protein 2, DOC2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9BYR8 KRTAP3-1

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External Reference Information

External Reference

UniProt:Q92608 DOCK2

Gene Names

DOCK2, KIAA0209

Chain

chain:1-1830

Reference Genes

COSMIC (genes):DOCK2 Q926082

dbSNP Gene:1794 Q926082

ENSEMBL:ENSG00000134516 DOCK2

Participates

as a candidate of

as a member of

as a component of

DOCK2:ELMO1:RAC1:Nef Complex [cytosol] (Homo sapiens)

as an input of

Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)

Other forms of this molecule

DOCK2 [specific granule lumen]

DOCK2 [extracellular region]

Inferred To

docA [cytosol] (Dictyostelium discoideum)

Homologues of DOCK2 [cytosol] (Dictyostelium discoideum)

docB [cytosol] (Dictyostelium discoideum)

docD [cytosol] (Dictyostelium discoideum)

docC [cytosol] (Dictyostelium discoideum)

dock2 [cytosol] (Xenopus tropicalis)

ced-5 [cytosol] (Caenorhabditis elegans)

DCK1 [cytosol] (Saccharomyces cerevisiae)

Dock2 [cytosol] (Mus musculus)

Dock2 [cytosol] (Rattus norvegicus)

DOCK2 [cytosol] (Bos taurus)

DOCK2 [cytosol] (Canis familiaris)

DOCK2 [cytosol] (Gallus gallus)

DOCK2 [cytosol] (Sus scrofa)

mbc [cytosol] (Drosophila melanogaster)

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.718	6
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.718	6
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.718	6
UniProt:Q99750 MDFI			0.718	8
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.718	6
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.589	3
IntAct:EBI-7355238 Q85737			0.558	5
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.556	6
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.556	3
UniProt:P22735 TGM1	3	TGM1 [cytosol] (R-HSA-6813756) TGM1 [cornified envelope] (R-HSA-8847706) TGM1 [plasma membrane] (R-HSA-6813757)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:Q9BYQ3 KRTAP9-3	1	KRTAP9-3 [cytosol] (R-HSA-6809954)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q9BYQ2 KRTAP9-4	1	KRTAP9-4 [cytosol] (R-HSA-6809971)	0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:O15162 PLS1			0.556	3
UniProt:Q6L8G8 KRTAP5-7	1	KRTAP5-7 [cytosol] (R-HSA-6810273)	0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:O75525 KHDRBS3	2	KHDRSB3 [nucleoplasm] (R-HSA-8849040) p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:O95273 CCDB1			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:P61978-2 HNRNPK			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	5
IntAct:EBI-10173330 386677			0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
UniProt:Q9BYP8 KRTAP17-1	1	KRTAP17-1 [cytosol] (R-HSA-6809980)	0.556	3
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
UniProt:Q92824-2 PCSK5			0.556	3
UniProt:Q9BYR6 KRTAP3-3	1	KRTAP3-3 [cytosol] (R-HSA-6809859)	0.556	3
UniProt:Q9BWT7 CAR10			0.556	3
UniProt:Q6N022 TEN4			0.556	3
UniProt:Q8IUG1 KRTAP1-3	1	KRTAP1-3 [cytosol] (R-HSA-6809866)	0.556	3

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