Reactome | WASF3 [cytosol]

WASF3 [cytosol]

Stable Identifier

R-HSA-200975

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Wave3

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Parasite infection (Homo sapiens)
        
        Leishmania phagocytosis (Homo sapiens)
        
        FCGR3A-mediated phagocytosis (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
        
        ABL phosphorylates WAVEs (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC) (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        WRC:IRSp53/58:RAC1:GTP:PIP3 [plasma membrane] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RAC1 GTPase cycle (Homo sapiens)
        
        RAC1 binds effectors at the plasma membrane (Homo sapiens)
        
        RAC1 effectors [cytosol] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)
        
        RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
        
        RAC1 effectors [cytosol] (Homo sapiens)
        
        WAVE Regulatory Complex [cytosol] (Homo sapiens)
        
        WAVEs [cytosol] (Homo sapiens)
        
        WASF3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UPY6 WASF3

Gene Names

WASF3, KIAA0900, SCAR3, WAVE3

Chain

chain:1-502

Reference Genes

BioGPS Gene:10810 WASF3

COSMIC (genes):WASF3 WASF3

CTD Gene:10810 WASF3

dbSNP Gene:10810 WASF3

ENSEMBL:ENSG00000132970 WASF3

ENSEMBL:ENSG00000132970.14 WASF3

HGNC:12734 WASF3

KEGG Gene (Homo sapiens):10810 WASF3

Monarch:10810 WASF3

NCBI Gene:10810 WASF3

OMIM:605068 WASF3

UCSC:Q9UPY6 WASF3

Reference Transcript

Other Identifiers

1058_at

10810

11719975_at

11719976_at

11757981_s_at

16773453

204042_PM_at

204042_at

3482588

3482589

3482590

3482608

3482610

3482617

3482618

3482622

3482623

3482624

3482627

3482629

3482630

3482631

3482632

3482633

3482634

3482635

3482636

3482637

3482638

3482639

7968212

A_14_P108815

A_24_P176079

GE53572

GE81664

GO:0003779

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005856

GO:0007010

GO:0008092

GO:0008360

GO:0014003

GO:0030027

GO:0030032

GO:0030036

GO:0030041

GO:0030154

GO:0031209

GO:0031643

GO:0034237

GO:0034330

GO:0043226

GO:0048856

GO:0050877

GO:0065003

GO:0070062

GO:0071933

GO:0097386

GO:0098794

GO:0098885

GO:0098978

GO:2000601

HMNXSV003012050

Hs.82318.0.A3_3p_at

ILMN_1810797

PH_hs_0004713

S69790_at

TC13000070.hg

Participates

as a candidate of

WAVEs [cytosol] (Homo sapiens)

Other forms of this molecule

p-Y151,S,T-WASF3 [cytosol]

p-Y151-WASF3 [cytosol]

Inferred To

SCAR [cytosol] (Drosophila melanogaster)

WASF3 [cytosol] (Bos taurus)

WASF3 [cytosol] (Canis familiaris)

WASF3 [cytosol] (Gallus gallus)

WASF3 [cytosol] (Sus scrofa)

wve-1 [cytosol] (Caenorhabditis elegans)

Wasf3 [cytosol] (Mus musculus)

Wasf3 [cytosol] (Rattus norvegicus)

Homologues of WASF3 [cytosol] (Drosophila melanogaster)

gukh [cytosol] (Drosophila melanogaster)

wasf3 [cytosol] (Xenopus tropicalis)

zgc:158236 [cytosol] (Danio rerio)

scrA [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001278894.1, XP_011533192.1, XP_011533191.1, NP_006637.2

OpenTargets

ENSG00000132970

HPA

ENSG00000132970-WASF3

GeneCards

Q9UPY6

Ensembl

ENST00000361042, ENSP00000335055, ENSP00000354325, ENSG00000132970, ENST00000335327

PRO

Q9UPY6

Pharos - Targets

Q9UPY6

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2