ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA

Stable Identifier
R-HSA-201035
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
Synonyms
palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O, Conversion of palmitic acid to palmitoyl-CoA
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Membrane-associated acyl-CoA synthetase long-chain family members 1,3,5 and 6 (ACSL1,3,5,6) catalyse the conjugation of palmitate (PALM) with CoA to form palmitoyl-CoA (PALM-CoA). Human ACSL1 has not been characterized in detail, but available data suggest that it is associated specifically with the membrane of the endoplasmic reticulum and that it can act on oleic acid as well as on palmitic acid (Malhotra et al. 1999, Fujimoto et al. 2007, Gassler et al. 2007).
Literature References
PubMed ID Title Journal Year
17379924 Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7

Fujimoto, Y, Itabe, H, Kinoshita, T, Homma, KJ, Onoduka, J, Mori, M, Yamaguchi, S, Makita, M, Higashi, Y, Yamashita, A, Takano, T

J Lipid Res 2007
17681178 Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing

Gassler, N, Roth, W, Funke, B, Schneider, A, Herzog, F, Tischendorf, JJ, Grund, K, Penzel, R, Bravo, IG, Mariadason, J, Ehemann, V, Sykora, J, Haas, TL, Walczak, H, Ganten, T, Zentgraf, H, Erb, P, Alonso, A, Autschbach, F, Schirmacher, P, Knuchel, R, Kopitz, J

Gastroenterology 2007
10548543 Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors

Malhotra, KT, Malhotra, K, Lubin, BH, Kuypers, FA

Biochem J 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

long-chain fatty acid-CoA ligase activity of ACSL1,3,5,6 [endoplasmic reticulum membrane]

Physical Entity
ACSL1,3,5,6 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
long-chain fatty acid-CoA ligase activity (GO:0004467)
Orthologous Events
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Bos taurus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Caenorhabditis elegans)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Canis familiaris)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Danio rerio)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Dictyostelium discoideum)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Drosophila melanogaster)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Gallus gallus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Mus musculus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Plasmodium falciparum)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Rattus norvegicus)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Saccharomyces cerevisiae)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Schizosaccharomyces pombe)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Sus scrofa)
ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA (Xenopus tropicalis)
Cross References
RHEA
Authored
Gopinathrao, G  (2007-07-30)
Reviewed
D'Eustachio, P  (2015-02-22)
Created
Gopinathrao, G  (2007-07-29)
Cite Us!