ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA

Stable Identifier
Reaction [transition]
Homo sapiens
palmitate + CoASH + ATP => palmitoyl-CoA + AMP + pyrophosphate + H2O, Conversion of palmitic acid to palmitoyl-CoA
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Membrane-associated acyl-CoA synthetase long-chain family members 1,3,5 and 6 (ACSL1,3,5,6) catalyse the conjugation of palmitate (PALM) with CoA to form palmitoyl-CoA (PALM-CoA). Human ACSL1 has not been characterized in detail, but available data suggest that it is associated specifically with the membrane of the endoplasmic reticulum and that it can act on oleic acid as well as on palmitic acid (Malhotra et al. 1999, Fujimoto et al. 2007, Gassler et al. 2007).
Literature References
PubMed ID Title Journal Year
17379924 Involvement of ACSL in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH7

Yamashita, A, Higashi, Y, Yamaguchi, S, Kinoshita, T, Takano, T, Homma, KJ, Fujimoto, Y, Mori, M, Itabe, H, Makita, M, Onoduka, J

J Lipid Res 2007
17681178 Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing

Ganten, T, Ehemann, V, Penzel, R, Alonso, A, Roth, W, Mariadason, J, Funke, B, Haas, TL, Autschbach, F, Kopitz, J, Knuchel, R, Schirmacher, P, Walczak, H, Sykora, J, Herzog, F, Gassler, N, Erb, P, Schneider, A, Zentgraf, H, Grund, K, Tischendorf, JJ, Bravo, IG

Gastroenterology 2007
10548543 Identification and molecular characterization of acyl-CoA synthetase in human erythrocytes and erythroid precursors

Kuypers, FA, Lubin, BH, Malhotra, K, Malhotra, KT

Biochem J 1999
Catalyst Activity

long-chain fatty acid-CoA ligase activity of ACSL1,3,5,6 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
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