p-8Y-FGFR1c P252S [plasma membrane]

Stable Identifier
R-HSA-2011861
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
p-8Y-FGFR1c P252S [plasma membrane] icon
Locations in the PathwayBrowser
General
thought to increase # hydrogen bonds, increase ligand affinity and ligand binding range (Ruhe 2007)
Literature References
PubMed ID Title Journal Year
18056464 Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines

Tay, LS, Streit, S, Lee, TC, Ullrich, A, Loo, HL, Lim, SJ, Venkatesh, B, Foo, P, Mann, C, Luo, M, Peng, K, Wong, CH, Ong, H, Wong, W, Gaertner, S, Tay, A, Pok, S, Hart, S, Peter, S, Hoefler, H, Bezler, M, Ruhe, JE, Ho, HK, Knyazev, P, Iacobelli, S, Brenner, S, Knyazeva, T, Specht, K

Cancer Res 2007
External Reference Information
External Reference
Gene Names
FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Other Identifiers
11716548_x_at
11727300_a_at
11727301_a_at
11734765_a_at
11747416_a_at
11747417_x_at
2056_at
2057_g_at
207937_PM_x_at
207937_x_at
211535_PM_s_at
211535_s_at
2260
226705_PM_at
226705_at
3132013
3132015
3132017
3132018
3132019
3132020
3132021
3132022
3132023
3132025
3132026
3132027
3132028
3132029
3132031
3132033
3132036
3132039
3132041
3132044
3132046
3132055
3132056
3132070
3132072
3132076
3132078
3132080
3132081
3132083
3132095
3132108
3132109
3132111
3132112
3132113
3132114
3132115
3132116
3493097
36168_at
424_s_at
53212_at
8150318
91005_at
A_23_P301304
A_23_P372923
A_24_P4171
GE59934
GO:0000122
GO:0000165
GO:0000166
GO:0000278
GO:0001501
GO:0001525
GO:0001657
GO:0001701
GO:0001759
GO:0001764
GO:0001837
GO:0002053
GO:0002062
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006260
GO:0006351
GO:0006355
GO:0006468
GO:0006629
GO:0006766
GO:0007165
GO:0007169
GO:0007420
GO:0007435
GO:0007605
GO:0008201
GO:0008283
GO:0008284
GO:0008543
GO:0010463
GO:0010467
GO:0010468
GO:0010518
GO:0010629
GO:0010863
GO:0010966
GO:0010976
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0017134
GO:0018108
GO:0021769
GO:0021847
GO:0023052
GO:0030031
GO:0030154
GO:0030324
GO:0030326
GO:0030901
GO:0031175
GO:0031410
GO:0031982
GO:0035607
GO:0036211
GO:0042169
GO:0042472
GO:0042473
GO:0042474
GO:0042802
GO:0042803
GO:0043009
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043536
GO:0043583
GO:0045595
GO:0045597
GO:0045666
GO:0045787
GO:0046777
GO:0048015
GO:0048339
GO:0048378
GO:0048469
GO:0048513
GO:0048514
GO:0048699
GO:0048705
GO:0048762
GO:0048856
GO:0048863
GO:0048870
GO:0050678
GO:0050877
GO:0050886
GO:0051174
GO:0051897
GO:0055065
GO:0055074
GO:0060038
GO:0060045
GO:0060089
GO:0060117
GO:0060445
GO:0060484
GO:0060665
GO:0070640
GO:0071344
GO:0071529
GO:0072089
GO:0090080
GO:0090272
GO:0090722
GO:0140096
GO:1903465
GO:1904383
GO:1905564
GO:2000546
GO:2000648
GO:2000830
GO:2001239
HMNXSV003006005
HMNXSV003036243
Hs.748.8.A1_3p_at
ILMN_1729369
ILMN_1796229
ILMN_2398261
PH_hs_0000085
X66945_at
g13186246_3p_a_at
g182560_3p_a_at
Participates
Other forms of this molecule
Inferred From
Modified Residues
Name
L-proline 252 replaced with L-serine
Coordinate
252
PsiMod
A protein modification that effectively removes or replaces an L-proline.
A protein modification that effectively converts a source amino acid residue to L-serine.
Name
O4'-phospho-L-tyrosine at 463
Coordinate
463
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 583
Coordinate
583
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 585
Coordinate
585
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 653
Coordinate
653
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 654
Coordinate
654
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 730
Coordinate
730
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 766
Coordinate
766
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 776
Coordinate
776
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
melanoma DOID:1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Interactors (25)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P09038 FGF2  1 0.912 9
 UniProt:P19174 PLCG1  6 0.903 11
 UniProt:P05230 FGF1  1 0.789 4
 UniProt:P46934 NEDD4  1 0.672 26
 UniProt:P08238 HSP90AB1  6 0.669 3
 UniProt:P27986 PIK3R1  16 0.644 6
 UniProt:Q8IVI9 NOSTRIN  2 0.633 5
 UniProt:P23352 ANOS1  1 0.626 7
 UniProt:P35222 CTNNB1  20 0.623 3
 UniProt:P11362 FGFR1  9 0.623 4
 UniProt:P08908 HTR1A  1 0.62 9
 UniProt:P10686 Plcg1  8 0.611 4
 UniProt:Q16543 CDC37  1 0.569 4
 UniProt:Q9NQH7 XPP3      0.569 3
 UniProt:Q8WU20 FRS2  6 0.569 3
 UniProt:P51812 RPS6KA3  7 0.569 3
 UniProt:O35082  2 0.558 2
 UniProt:Q9GZV9 FGF23  6 0.544 2
 UniProt:P22455 FGFR4  12 0.539 3
 UniProt:P12830 CDH1  8 0.536 3
 UniProt:P21802 FGFR2  20 0.499 2
 UniProt:Q7KZF4 SND1  2 0.483 2
 UniProt:P06493 CDK1  11 0.483 3
 UniProt:P46108 CRK  1 0.483 2
 UniProt:O88900  1 0.471 3
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