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BMP:BMPRII:p-4S-BMPRI [plasma membrane]
Stable Identifier
R-HSA-201426
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
BMP:BMPRII:P-BMPRI, Dimeric BMP2:BMP type II receptor:Phospho-BMP type I receptor complex
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
Type II receptor phosphorylates type I receptor (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
Participants
components
BMP2 dimer [extracellular region]
(Homo sapiens)
BMPRII dimer [plasma membrane]
(Homo sapiens)
p-4S-BMPRI dimer [plasma membrane]
(Homo sapiens)
Participates
as a component of
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
as an input of
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)
as an output of
Type II receptor phosphorylates type I receptor (Homo sapiens)
Inferred To
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
(Bos taurus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
(Caenorhabditis elegans)
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
(Canis familiaris)
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
(Danio rerio)
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
(Drosophila melanogaster)
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
(Gallus gallus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
(Mus musculus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
(Rattus norvegicus)
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
(Sus scrofa)
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
(Xenopus tropicalis)
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