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p-S463,S465-SMAD5 [nucleoplasm]
Stable Identifier
R-HSA-201432
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Phospho-R-SMAD5, Mothers against decapentaplegic homolog 5, SMA5_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
SKI complexes with the Smad complex, suppressing BMP2 signalling (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD5 [nucleoplasm] (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4:SKI [nucleoplasm] (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD5 [nucleoplasm] (Homo sapiens)
The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD5 [nucleoplasm] (Homo sapiens)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S463,S465-SMAD5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99717 SMAD5
Gene Names
SMAD5, MADH5
Chain
initiator methionine:, chain:2-465
Reference Genes
BioGPS Gene:4090 SMAD5
COSMIC (genes):SMAD5 SMAD5
CTD Gene:4090 SMAD5
dbSNP Gene:4090 SMAD5
ENSEMBL:ENSG00000113658 SMAD5
ENSEMBL_homo_sapiens_GENE:ENSG00000113658.18 SMAD5
HGNC:6771 SMAD5
KEGG Gene (Homo sapiens):4090 SMAD5
Monarch:4090 SMAD5
NCBI Gene:4090 SMAD5
OMIM:603110 SMAD5
UCSC:Q99717 SMAD5
Reference Transcript
RefSeq:NM_005903.6 SMAD5
RefSeq:NM_001001420.2 SMAD5
RefSeq:NM_001001419.2 SMAD5
RefSeq:XM_017009470.1 SMAD5
Other Identifiers
1013_at
11729717_a_at
11729718_s_at
11729719_a_at
11741023_a_at
11757679_s_at
16989534
1952_s_at
205187_PM_at
205187_at
205188_PM_s_at
205188_s_at
225219_PM_at
225219_at
225223_PM_at
225223_at
235451_PM_at
235451_at
2830018
2830019
2830020
2830021
2830022
2830023
2830024
2830027
2830029
2830030
2830031
2830032
2830037
2830039
2830041
2830043
2830046
2830047
2830048
2830049
2830050
39926_at
4090
54698_at
8108238
84185_r_at
A_14_P106211
A_14_P121517
A_14_P123776
A_14_P137757
A_19_P00804893
A_23_P144944
A_33_P3220445
GE55680
GE79186
GO:0000122
GO:0000785
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0001503
GO:0001649
GO:0001657
GO:0001880
GO:0002051
GO:0002376
GO:0003012
GO:0003013
GO:0003161
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0007165
GO:0007179
GO:0007281
GO:0009653
GO:0009880
GO:0010629
GO:0012501
GO:0017151
GO:0022414
GO:0023052
GO:0030154
GO:0030218
GO:0030509
GO:0031625
GO:0032991
GO:0043066
GO:0043226
GO:0045669
GO:0045893
GO:0045944
GO:0046872
GO:0048856
GO:0051216
GO:0060048
GO:0060348
GO:0060395
GO:0070411
GO:0071141
GO:0071144
GO:0071407
GO:0140110
GO:1902045
GO:1990837
HMNXSV003024162
Hs.165210.0.A1_3p_at
Hs.167700.0.S1_3p_at
Hs.167700.0.S2_3p_at
ILMN_1674551
ILMN_2371984
PH_hs_0022793
TC05000683.hg
TC05002640.hg
U59913_at
g2317785_3p_at
g5174514_3p_a_at
Participates
as a member of
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
SMAD5 [cytosol]
p-S463,S465-SMAD5 [cytosol]
Inferred To
phospho-SMAD5 [nucleoplasm]
(Bos taurus)
phospho-SMAD5 [nucleoplasm]
(Canis familiaris)
phospho-SMAD5 [nucleoplasm]
(Sus scrofa)
phospho-p-S463,S465-SMAD5 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S463,S465-SMAD5 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-S463,S465-SMAD5 [nucleoplasm]
(Mus musculus)
phospho-p-S463,S465-SMAD5 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 463
Coordinate
463
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 465
Coordinate
465
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001001419.1
,
NP_005894.3
,
NP_001001420.1
,
XP_016864959.1
OpenTargets
ENSG00000113658
GeneCards
Q99717
HPA
ENSG00000113658-SMAD5
Ensembl
ENST00000545279
,
ENST00000545620
,
ENSP00000441954
,
ENST00000509297
,
ENSP00000426696
,
ENSP00000446474
,
ENSG00000113658
PRO
Q99717
Pharos - Targets
Q99717
PDB
6TCE
,
6FZS
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HAU4 SMURF2
2
SMURF2 [nucleoplasm]
(R-HSA-178202)
SMURF2 [cytosol]
(R-HSA-173537)
0.659
3
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.558
3
UniProt:Q9H8X2 IPPK
2
IPPK [cytosol]
(R-HSA-1604598)
IPPK [nucleoplasm]
(R-HSA-2023949)
0.527
2
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