Reactome | p-S465,S467-SMAD9 [cytosol]

p-S465,S467-SMAD9 [cytosol]

Stable Identifier

R-HSA-201441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phospho-R-SMAD8, Mothers against decapentaplegic homolog 9, SMA9_HUMAN

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O15198 SMAD9

Gene Names

SMAD9, MADH6, MADH9, SMAD8

Chain

chain:1-467

Reference Genes

COSMIC (genes):SMAD9 SMAD9

dbSNP Gene:4093 SMAD9

ENSEMBL:ENSG00000120693 SMAD9

Participates

as a member of

p-2S-SMAD1/5/8 [cytosol] (Homo sapiens)

Other forms of this molecule

SMAD9 [cytosol]

p-S465,S467-SMAD9 [nucleoplasm]

Inferred To

Homologues of p-S465,S467-SMAD9 [cytosol] (Caenorhabditis elegans)

phospho-smad9 [cytosol] (Danio rerio)

phospho-smad9 [cytosol] (Xenopus tropicalis)

phospho-daf-14 [cytosol] (Caenorhabditis elegans)

phospho-p-S465,S467-SMAD9 [cytosol] (Caenorhabditis elegans)

phospho-p-S465,S467-SMAD9 [cytosol] (Drosophila melanogaster)

phospho-p-S465,S467-SMAD9 [cytosol] (Gallus gallus)

phospho-p-S465,S467-SMAD9 [cytosol] (Mus musculus)

phospho-p-S465,S467-SMAD9 [cytosol] (Rattus norvegicus)

phospho-SMAD9 [cytosol] (Bos taurus)

phospho-SMAD9 [cytosol] (Canis familiaris)

phospho-SMAD9 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 465

Coordinate

465

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 467

Coordinate

467

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.748	4
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) Ub,p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-9773843) SMAD2 [nucleoplasm] (R-HSA-3006352) p-S250-SMAD2 [cytosol] (R-HSA-9731121) SMAD2 Q429* [cytosol] (R-HSA-9668727) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 S296* [cytosol] (R-HSA-9668729)	0.547	2
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.508	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2

Cite Us!