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BMPR2 [plasma membrane]
Stable Identifier
R-HSA-201442
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Bone morphogenetic protein receptor type II, BMR2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
BMP2 binds to the receptor complex (Homo sapiens)
BMP:BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
Formation of a heteromeric BMP receptor complex (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)
BMP:p-BMPR:Endofin [early endosome membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
Type II receptor phosphorylates type I receptor (Homo sapiens)
BMP:BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII:BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
BMPRII dimer [plasma membrane] (Homo sapiens)
Type II receptor [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
BMPR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13873 BMPR2
Gene Names
BMPR2, PPH1
Chain
signal peptide:1-26, chain:27-1038
Reference Genes
BioGPS Gene:659 BMPR2
COSMIC (genes):BMPR2 BMPR2
CTD Gene:659 BMPR2
dbSNP Gene:659 BMPR2
ENSEMBL:ENSG00000204217 BMPR2
ENSEMBL_homo_sapiens_GENE:ENSG00000204217.16 BMPR2
HGNC:1078 BMPR2
KEGG Gene (Homo sapiens):659 BMPR2
Monarch:659 BMPR2
NCBI Gene:659 BMPR2
OMIM:600799 BMPR2
UCSC:Q13873 BMPR2
Reference Transcript
RefSeq:NM_001204.6 BMPR2
Other Identifiers
11728699_at
11728700_a_at
11756105_a_at
16889636
209920_PM_at
209920_at
210214_PM_s_at
210214_s_at
225144_PM_at
225144_at
231873_PM_at
231873_at
238516_PM_at
238516_at
2523214
2523215
2523228
2523229
2523230
2523231
2523237
2523238
2523239
2523240
2523241
2523242
2523245
2523246
2523247
2523248
2523249
2523250
2523251
2523252
2523253
2523254
2523255
2523256
2523257
39998_at
44148_at
51825_r_at
53744_at
659
76926_at
8047538
89346_at
A_14_P103362
A_14_P130646
A_23_P96144
GE58249
GE85395
GO:0000166
GO:0001568
GO:0001649
GO:0001707
GO:0001893
GO:0001935
GO:0001946
GO:0001974
GO:0002063
GO:0003013
GO:0003085
GO:0003151
GO:0003176
GO:0003177
GO:0003183
GO:0003186
GO:0003197
GO:0003252
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005024
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005886
GO:0005901
GO:0005905
GO:0005912
GO:0006351
GO:0006355
GO:0006468
GO:0007178
GO:0009267
GO:0009925
GO:0009952
GO:0009986
GO:0010628
GO:0010634
GO:0012501
GO:0014069
GO:0014916
GO:0016020
GO:0016301
GO:0016310
GO:0016324
GO:0016362
GO:0016740
GO:0019838
GO:0022414
GO:0023052
GO:0030154
GO:0030166
GO:0030308
GO:0030424
GO:0030425
GO:0030501
GO:0030509
GO:0032924
GO:0036122
GO:0036211
GO:0038023
GO:0042127
GO:0043025
GO:0043226
GO:0043235
GO:0044297
GO:0045296
GO:0045669
GO:0045778
GO:0045906
GO:0045944
GO:0046872
GO:0048286
GO:0048662
GO:0048842
GO:0048856
GO:0048870
GO:0051148
GO:0060041
GO:0060089
GO:0060173
GO:0060255
GO:0060350
GO:0060391
GO:0060412
GO:0060413
GO:0060426
GO:0060836
GO:0060840
GO:0060841
GO:0061036
GO:0061298
GO:0071363
GO:0071773
GO:0072577
GO:0098821
GO:0140096
GO:0141091
GO:1901135
GO:1902731
GO:1905314
GO:1990782
HMNXSV003024780
Hs.126351.0.A1_3p_at
Hs.28959.0.A1_3p_at
Hs.315284.0.S1_3p_at
ILMN_1789095
ILMN_2070896
PH_hs_0003544
TC02001192.hg
Z48923_at
g704361_3p_a_at
Participates
as a member of
Type II receptor [plasma membrane] (Homo sapiens)
Inferred To
BMPR2 [plasma membrane]
(Bos taurus)
BMPR2 [plasma membrane]
(Canis familiaris)
BMPR2 [plasma membrane]
(Danio rerio)
BMPR2 [plasma membrane]
(Drosophila melanogaster)
BMPR2 [plasma membrane]
(Gallus gallus)
BMPR2 [plasma membrane]
(Mus musculus)
BMPR2 [plasma membrane]
(Rattus norvegicus)
BMPR2 [plasma membrane]
(Sus scrofa)
BMPR2 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001195.2
ZINC - World Drugs
BMPR2_HUMAN
Guide to Pharmacology - Targets
1794
OpenTargets
ENSG00000204217
ZINC - FDA approved
BMPR2_HUMAN
ZINC - Substances
BMPR2_HUMAN
ZINC - Biogenic
BMPR2_HUMAN
ZINC target
Q13873
PRO
Q13873
PDB
7U5O
,
6UNP
,
7PPC
,
7PPA
,
2HLQ
,
3G2F
,
7PPB
ZINC - Investigational
BMPR2_HUMAN
IntEnz
2.7.11.30
HPA
ENSG00000204217-BMPR2
GeneCards
Q13873
Ensembl
ENST00000374574
,
ENSP00000363702
,
ENSP00000363708
,
ENSG00000204217
,
ENST00000374580
Pharos - Targets
Q13873
ZINC - Predictions - Purchasable
BMPR2_HUMAN
Orphanet
15374
HMDB Protein
HMDBP01461
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P68404
5
phospho-p-T500,T642,S661-PRKCB [nucleoplasm]
(R-MMU-5223294)
phospho-p-T500,T642,S661-PRKCB [cytosol]
(R-MMU-5218706)
phospho-p-T500-PRKCB [cytosol]
(R-MMU-5218728)
PRKCB [cytosol]
(R-MMU-58198)
PRKCB [plasma membrane]
(R-MMU-156467)
0.499
4
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