The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus

Stable Identifier
Reaction [transition]
Homo sapiens
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The phosphorylated-r-SMAD1/5/8:Co-SMAD complex rapidly translocates to the nucleus where it binds directly to DNA and interacts with a plethora of transcription co-factors. Regulation of target gene expression can be either positive or negative. A classic example of a target gene of the pathway are the genes encoding for i-SMADs. Thus, BMP2/SMAD signalling induces the expression of the negative regulators of the pathway (a negative feedback loop).

Literature References
PubMed ID Title Journal Year
12592392 An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity

Xiao, Z, Latek, R, Lodish, HF

Oncogene 2003
12821673 A novel nuclear export signal in Smad1 is essential for its signaling activity

Xiao, Z, Brownawell, AM, Macara, IG, Lodish, HF

J Biol Chem 2003
11509558 Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals

Xiao, Z, Watson, N, Rodriguez, C, Lodish, HF

J Biol Chem 2001
Orthologous Events
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