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PTN [extracellular region]
Stable Identifier
R-HSA-201500
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Pleiotrophin, PTN_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9UBS4 DNAJB11
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
MDK and PTN in ALK signaling (Homo sapiens)
ALK binds ligand pleiotrophin (PTN) (Homo sapiens)
PTN [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21246 PTN
Gene Names
PTN, HBNF1, NEGF1
Chain
signal peptide:1-32, chain:33-168
Reference Genes
BioGPS Gene:5764 PTN
COSMIC (genes):PTN PTN
CTD Gene:5764 PTN
dbSNP Gene:5764 PTN
ENSEMBL:ENSG00000105894 PTN
ENSEMBL_homo_sapiens_GENE:ENSG00000105894.13 PTN
HGNC:9630 PTN
KEGG Gene (Homo sapiens):5764 PTN
Monarch:5764 PTN
NCBI Gene:5764 PTN
OMIM:162095 PTN
UCSC:P21246 PTN
Reference Transcript
RefSeq:NM_002825.6 PTN
RefSeq:NM_001321387.2 PTN
RefSeq:NM_001321386.2 PTN
Other Identifiers
11723961_s_at
11753666_x_at
17063254
209465_PM_x_at
209465_x_at
209466_PM_x_at
209466_x_at
211737_PM_x_at
211737_x_at
234_s_at
3074856
3074858
3074859
3074860
3074861
3074872
3074873
3074874
3074901
3074902
3074903
34820_at
45061_at
5764
8143144
A_23_P303087
GE490527
GE57981
GO:0001503
GO:0002232
GO:0002376
GO:0002690
GO:0004864
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005886
GO:0006954
GO:0007185
GO:0007229
GO:0007399
GO:0007406
GO:0007612
GO:0007613
GO:0008083
GO:0008201
GO:0008284
GO:0010594
GO:0010976
GO:0010996
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0030246
GO:0030282
GO:0030501
GO:0031104
GO:0031641
GO:0032991
GO:0035374
GO:0042246
GO:0043113
GO:0043226
GO:0043932
GO:0044849
GO:0045597
GO:0045778
GO:0046697
GO:0048018
GO:0048167
GO:0048477
GO:0048680
GO:0048714
GO:0048856
GO:0048870
GO:0050804
GO:0050877
GO:0050896
GO:0051781
GO:0098685
GO:0098772
GO:0140059
GO:0140677
GO:1900006
GO:1900272
GO:1903706
GO:2000036
GO:2000347
GO:2000738
HMNXSV003024258
ILMN_1813753
M57399_at
PH_hs_0000005
TC07001895.hg
g292072_3p_s_at
Participates
as a member of
PTN,MDK [extracellular region] (Homo sapiens)
as a component of
PTN:p-7Y ALK dimer [plasma membrane] (Homo sapiens)
PTN:ALK [plasma membrane] (Homo sapiens)
PTN:ALK dimer [plasma membrane] (Homo sapiens)
as an input of
ALK binds ligand pleiotrophin (PTN) (Homo sapiens)
Inferred To
Ptn [extracellular region]
(Mus musculus)
Pleiotrophin [extracellular region]
(Rattus norvegicus)
ptn [extracellular region]
(Danio rerio)
ptn [extracellular region]
(Xenopus tropicalis)
PTN [extracellular region]
(Bos taurus)
PTN [extracellular region]
(Canis familiaris)
PTN [extracellular region]
(Gallus gallus)
PTN [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_001308316.1
,
NP_002816.1
,
NP_001308315.1
OpenTargets
ENSG00000105894
HPA
ENSG00000105894-PTN
GeneCards
P21246
Ensembl
ENSP00000341170
,
ENST00000348225
,
ENSG00000105894
PRO
P21246
Pharos - Targets
P21246
PDB
2N6F
HMDB Protein
HMDBP02150
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11215 ITGAM
3
ITGAM [specific granule membrane]
(R-HSA-6799647)
ITGAM [tertiary granule membrane]
(R-HSA-6800979)
ITGAM [plasma membrane]
(R-HSA-202757)
0.618
3
UniProt:P50454 SERPINH1
1
SERPINH1 [endoplasmic reticulum lumen]
(R-HSA-2127480)
0.556
3
UniProt:Q92876 KLK6
0.556
3
UniProt:Q12797-6 ASPH
0.556
3
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.556
3
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.556
3
UniProt:O43765 SGTA
1
SGTA [cytosol]
(R-HSA-5423595)
0.553
2
UniProt:Q9NRR5 UBQL4
0.553
2
UniProt:Q12873 CHD3
2
CHD3 [nucleoplasm]
(R-HSA-4657012)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
0.553
2
UniProt:Q9H5J8 TAF1D
1
TAF1D [nucleoplasm]
(R-HSA-5138533)
0.553
2
UniProt:Q9UBS4 DNAJB11
1
DNAJB11 [endoplasmic reticulum lumen]
(R-HSA-381040)
0.553
2
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